Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ALPK2 (Q86TB3) - Overview - Molecular Target Synopsis


ALPK2, Alpha-protein kinase 2
Enzyme Classification 2.7.11.-
UniProt Q86TB3

Also Known as ALPK2_HUMAN, ALPK2, HAK

Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Gene Copy Number Variation

In COSMIC - Cell Lines Project ALPK2 has gain in 3 cell-lines, loss in 15 cell-lines and no signal in 987 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: A498, ACHN, SNB_75

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LOU-NH91, G112, G122

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, BJ

(see details)

RNA Interference

ALPK2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: COV504, CASKI. (see details)

3D Structures

At greater than 35% identity similarity to ALPK2 there are:
3 structures (6 chains) solved
2 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

ALPK2 has been screened with compounds ( bioactivities). (see details)