Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ALPK2 (Q86TB3) - Overview - Molecular Target Synopsis

Protein


ALPK2, Alpha-protein kinase 2
Enzyme Classification 2.7.11.-
UniProt Q86TB3

Also Known as ALPK2_HUMAN, ALPK2, HAK

Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
2170ENSG00000198796ENST00000361673ENSP00000354991Q86TB3-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project ALPK2 has gain in 3 cell-lines, loss in 15 cell-lines and no signal in 987 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A498, ACHN, SNB_75

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LOU-NH91, G112, G122

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, BJ

(see details)

RNA Interference


ALPK2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: COV504, CASKI. (see details)

3D Structures


At greater than 35% identity similarity to ALPK2 there are:
3 structures (6 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ALPK2 has been screened with compounds ( bioactivities). (see details)