Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SCD5 (Q86SK9) - Overview - Molecular Target Synopsis

Protein


SCD5, Stearoyl-CoA desaturase 5
Enzyme Classification 1.14.19.1
UniProt Q86SK9

Also Known as SCD5_HUMAN, SCD5, ACOD4, SCD2, SCD4

Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:15610069). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. May self-associate and form homodimers.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SCD5 is active in the following subcellular-locations: endoplasmic reticulum membrane.
GO terms: SCD5 is active in the following subcellular-locations: endoplasmic reticulum membrane, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SCD5 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CCRF_CEM, OVCAR_4, OVCAR_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NIH:OVCAR-3, DMS 79, KP4

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHEK, HSMM, BJ

(see details)

3D Structures


At greater than 50% identity similarity to SCD5 there are:
2 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SCD5 has been screened with 22 compounds (22 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)