NEK8 (Q86SG6) - Overview - Molecular Target Synopsis
NEK8, Serine/threonine-protein kinase Nek8
Enzyme Classification 220.127.116.11
Also Known as NEK8_HUMAN, NEK8, JCK, NEK12A
Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. Interacts with PKD2; may regulate PKD2 targeting to the cilium (By similarity). Component of a complex containing at least ANKS6, INVS, NEK8 and NPHP3. ANKS6 may organize complex assembly by linking INVS and NPHP3 to NEK8 and INVS may target the complex to the proximal ciliary axoneme. Interacts with ANKS3.
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UniProt: NEK8 is active in the following subcellular-locations: cell projection, cilium, cytoplasm, cytoskeleton.
GO terms: NEK8 is active in the following subcellular-locations: ciliary base, ciliary inversin compartment, cilium, cytoplasm, cytoskeleton.