Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

pphA (Q84G06) - Overview - Molecular Target Synopsis

Protein


pphA, Phosphonopyruvate hydrolase
Enzyme Classification 3.11.1.3
UniProt Q84G06

Also Known as PPHA_VARSP, pphA, palA

Hydrolyzes phosphonopyruvate. Not active towards phosphoenolpyruvate, glycerophosphate, phospho-L-serine or phosphoglycolic acid. Homodimer (PubMed:12697754). Homotetramer (PubMed:16981709).

2DUA
CRYSTAL STRUCTURE OF PHOSPHONOPYRUVATE HYDROLASE COMPLEX WITH OXALATE AND MG++
RCSB/PDB
Inspect Structure
See all 3D Structures for pphA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
290Q84G06-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project pphA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For pphA there are:
3 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis