Molecular Target Synopsis
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gyrB (Q839Z1) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed8
Chains with at least one site assessed as druggable using the strict criteria2
Chains with at least one site assessed as druggable using the relaxed criteria8


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4GFN_A DNA gyrase subunit B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 69.8 26.3 Yes No
2 bound 1.78 61.9 15.7 No No
3 empty 2.15 59.8 16.5 No No
4 empty 2.19 66.7 15.1 No No
5 empty 1.91 62.4 12.6 No No
6 empty 1.98 66.2 10.5 No No
7 empty 2.16 58.9 15.1 No No
8 empty 2.33 68.4 10.7 No No
9 empty 2.14 53 13.3 No No
10 empty 2.49 71 11.1 No No
4GEE_A DNA gyrase subunit B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 79.1 18.4 Yes Yes
2 bound 1.9 61.4 17 No No
3 empty 2.08 60.1 15.8 No No
4 empty 2.2 68.4 15.1 No No
5 empty 1.71 45.6 12.7 No No
6 empty 1.92 65.3 14.2 No No
7 empty 2.15 63.3 14.1 No No
8 empty 2.18 58.9 15.5 No No
9 empty 2.2 71.4 9.9 No No
10 empty 2.12 51.6 13.4 No No
4KSG_A DNA gyrase subunit B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 77.8 17.5 Yes No
2 bound 1.91 61.7 16.8 No No
3 empty 2.16 61 22.4 No No
4 empty 2.08 62.6 21 No No
5 empty 2.21 68.4 15.8 No No
6 empty 2.19 54 12.7 No No
7 empty 2.28 63 9.5 No No
8 empty 2.44 68.8 14.2 No No
9 empty 1.8 44.4 12.1 No No
10 empty 2.23 59.8 10.9 No No
4GGL_A DNA gyrase subunit B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 78.3 17.8 Yes No
2 bound 1.89 61.6 16.5 No No
3 empty 2.02 66.6 19 No No
4 empty 2.14 67.1 14.7 No No
5 empty 2.32 62.7 14 No No
6 empty 1.77 49 11.4 No No
7 empty 1.88 64.3 13.3 No No
8 empty 2.47 66.8 16.7 No No
9 empty 2.09 58.6 15.1 No No
10 empty 2.16 69.9 11.1 No No
4KSH_A DNA gyrase subunit B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 78.2 18.1 Yes No
2 bound 1.88 62.8 16.8 No No
3 empty 2.02 64.4 19.9 No No
4 empty 2.21 68.5 13.5 No No
5 empty 1.93 64 13.2 No No
6 empty 1.82 54.3 10.2 No No
7 empty 2.16 55.9 15.5 No No
8 empty 2.13 65.7 10.8 No No
9 empty 2.2 64.8 11.9 No No
10 empty 2.51 68.3 14.7 No No
4HXW_A DNA gyrase subunit B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 74.5 22.1 Yes No
2 bound 1.89 62.4 17 No No
3 empty 2.02 64.9 20.8 No No
4 empty 2.18 69.8 14.5 No No
5 empty 2.4 67.1 16.7 No No
6 empty 1.92 63.2 12.9 No No
7 empty 2.16 57.1 15 No No
8 empty 2.18 63.1 12.6 No No
9 empty 2.17 54.1 13.6 No No
10 empty 1.93 65.5 10.1 No No
4K4O_A DNA gyrase subunit B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.76 78.3 14.9 Yes No
2 empty 2.06 60.6 17.8 No No
3 empty 2.05 59.8 19.7 No No
4 empty 2.28 68.3 14.6 No No
5 empty 1.94 67.6 11.9 No No
6 empty 2.37 58.2 15.5 No No
7 empty 2.19 52.5 12.8 No No
8 empty 2.49 62.4 16.7 No No
9 empty 2.45 63.1 10.7 No No
10 empty 2.14 59.6 10.1 No No
4KTN_A DNA gyrase subunit B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 78.7 18.1 Yes Yes
2 empty 1.92 60 17.5 No No
3 empty 2.3 60 24.9 No No
4 empty 2.03 63.2 19.7 No No
5 empty 2.27 67.6 14.7 No No
6 empty 2.34 63.7 14.2 No No
7 empty 2.15 53.5 13.7 No No
8 empty 2.26 67.5 11.3 No No
9 empty 1.83 47.1 10.7 No No
10 empty 2.05 63.9 10.6 No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score