Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

gyrB (Q839Z1) - Overview - Molecular Target Synopsis

Protein


gyrB, DNA gyrase subunit B
Enzyme Classification 5.6.2.3
UniProt Q839Z1

Also Known as GYRB_ENTFA, gyrB

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis.

4KSH
DNA GYRASE ATP BINDING DOMAIN OF ENTEROCOCCUS FAECALIS IN COMPLEX WITH A SMALL MOLECULE INHIBITOR (7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5- CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5- NAPHTHYRIDIN-1(4H)-OL)
RCSB/PDB
Inspect Structure
See all 3D Structures for gyrB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
642Q839Z1-1

Sub-cellular localization


UniProt: gyrB is active in the following subcellular-locations: cytoplasm.
GO terms: gyrB is active in the following subcellular-locations: chromosome, cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project gyrB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For gyrB there are:
8 structures (8 chains) solved
8 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


gyrB has been screened with compounds ( bioactivities). (see details)