Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(Q83884) - Overview - Molecular Target Synopsis

Protein


, Capsid protein VP1
UniProt Q83884

Also Known as CAPSD_NVN68

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding histo-blood group antigens present on gastroduodenal epithelial cells., Soluble capsid protein may play a role in viral immunoevasion. Homodimerizes, then multimerizes. Binds to histo-blood group antigens at surface of target cells.

6OUT
ASYMMETRIC FOCUSED RECONSTRUCTION OF HUMAN NOROVIRUS GI.1 NORWALK STRAIN VLP ASYMMETRIC UNIT IN T=3 SYMMETRY
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
530Q83884-1

Sub-cellular localization


UniProt: is active in the following subcellular-locations: host cytoplasm, virion.
GO terms: is active in the following subcellular-locations: host cell cytoplasm, T=3 icosahedral viral capsid.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
16 structures (34 chains) solved
6 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

is solved in complex with the approved drug(s):

BGC/DEXTROSE (2ZL6_B).

(see details)
Molecular Target 3D Synopsis