Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ptcA (Q837U7) - Overview - Molecular Target Synopsis

Protein


ptcA, Putrescine carbamoyltransferase
Enzyme Classification 2.1.3.6
UniProt Q837U7

Also Known as PTC_ENTFA, ptcA, agcB, argF-2

Catalyzes the phosphorolysis of N-carbamoylputrescine to form carbamoyl phosphate and putrescine. Is involved in the degradation pathway of the polyamine agmatine. Also has weak activity with ornithine and cadaverine. Homotrimer.

4AM8
CRYSTAL STRUCTURE OF THE R54G MUTANT OF PUTRESCINE TRANSCARBAMYLASE FROM ENTEROCOCCUS FAECALIS BOUND TO A CURING GUANIDINIUM ION
RCSB/PDB
Inspect Structure
See all 3D Structures for ptcA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
339Q837U7-1

Sub-cellular localization


UniProt: ptcA is active in the following subcellular-locations: cytoplasm.
GO terms: ptcA is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ptcA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ptcA there are:
5 structures (27 chains) solved
4 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

ptcA is solved in complex with the approved drug(s):

GLN/GLUTAMINE (4AM8_A, 4AM8_C, 4AM8_E).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ptcA has been screened with compounds ( bioactivities). (see details)