Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

dltA (Q81G39) - Overview - Molecular Target Synopsis

Protein


dltA, D-alanine--D-alanyl carrier protein ligase
Enzyme Classification 6.2.1.-
UniProt Q81G39

Also Known as DLTA_BACCR, dltA

Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.

4PZP
SUBSTRATE-FREE STRUCTURE OF D-ALANINE CARRIER PROTEIN LIGASE DLTA FROM BACILLUS CEREUS
RCSB/PDB
Inspect Structure
See all 3D Structures for dltA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
504Q81G39-1, B7HHC6-1

Sub-cellular localization


UniProt: dltA is active in the following subcellular-locations: cytoplasm.
GO terms: dltA is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project dltA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For dltA there are:
4 structures (4 chains) solved
3 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

dltA is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3DHV_A).

(see details)
Molecular Target 3D Synopsis