Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

mdm4 (Q7ZUW7) - Overview - Molecular Target Synopsis

Protein


mdm4, Protein Mdm4
UniProt Q7ZUW7

Also Known as MDM4_DANRE, mdm4, mdmx

Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Binds to p73 (By similarity). Interacts directly with p53.

4N5T
THE 1.7A CRYSTAL STRUCTURE OF MDMX WITH A STAPLED PEPTIDE, ATSP-7041
RCSB/PDB
Inspect Structure
See all 3D Structures for mdm4

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
496Q7ZUW7-1
491Q7ZUW7-2

Sub-cellular localization


UniProt: mdm4 is active in the following subcellular-locations: nucleus.
GO terms: mdm4 is active in the following subcellular-locations: nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project mdm4 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For mdm4 there are:
4 structures (9 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


mdm4 has been screened with compounds ( bioactivities). (see details)