Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PXK (Q7Z7A4) - Overview - Molecular Target Synopsis

Protein


PXK, PX domain-containing protein kinase-like protein
UniProt Q7Z7A4

Also Known as PXK_HUMAN, PXK

Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PXK is active in the following subcellular-locations: cell membrane, cytoplasm.
GO terms: PXK is active in the following subcellular-locations: cytoplasm, cytosol, microtubule organizing center, nucleus, plasma membrane, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PXK has gain in 1 cell-lines, loss in 10 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, T47D, MDA_MB_231

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WSU-FSCCL, MHH-PREB-1, SKM-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, HSMM

(see details)

RNA Interference


PXK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MFM223, VP229. (see details)


Screening and Chemistry


PXK has been screened with compounds ( bioactivities). (see details)