Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ADAT2 (Q7Z6V5) - Overview - Molecular Target Synopsis

Protein


ADAT2, tRNA-specific adenosine deaminase 2
Enzyme Classification 3.5.4.33
UniProt Q7Z6V5

Also Known as ADAT2_HUMAN, ADAT2, DEADC1

Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

3DH1
CRYSTAL STRUCTURE OF HUMAN TRNA-SPECIFIC ADENOSINE-34 DEAMINASE SUBUNIT ADAT2
RCSB/PDB
Inspect Structure
See all 3D Structures for ADAT2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
191ENSG00000189007ENST00000237283ENSP00000237283Q7Z6V5-1
144ENSG00000189007ENST00000606514ENSP00000475651Q7Z6V5-2

Sub-cellular localization


GO terms: ADAT2 is active in the following subcellular-locations: nucleoplasm, tRNA-specific adenosine-34 deaminase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ADAT2 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, HL_60, SW_620

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KU812, HL-60, OCI-M2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, NHLF

(see details)

3D Structures


For ADAT2 there are:
1 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis