Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB44 (Q7Z6P3) - Overview - Molecular Target Synopsis

Protein


RAB44, Ras-related protein Rab-44
UniProt Q7Z6P3

Also Known as RAB44_HUMAN, RAB44

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
901ENSG00000255587ENST00000229824ENSP00000229824
723Q7Z6P3-1

Sub-cellular localization


UniProt: RAB44 is active in the following subcellular-locations: cell membrane.
GO terms: RAB44 is active in the following subcellular-locations: azurophil granule membrane, plasma membrane, specific granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB44 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: U-937, ML-2, THP-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to RAB44 there are:
109 structures (242 chains) solved
99 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RAB44 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3NKV_A, 3NKV_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB44 has been screened with compounds ( bioactivities). (see details)