Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ADCK2 (Q7Z695) - Overview - Molecular Target Synopsis

Protein


ADCK2, Uncharacterized aarF domain-containing protein kinase 2
Enzyme Classification 2.7.11.-
UniProt Q7Z695

Also Known as ADCK2_HUMAN, ADCK2, AARF

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ADCK2 is active in the following subcellular-locations: membrane.
GO terms: ADCK2 is active in the following subcellular-locations: integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ADCK2 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MOLT_4, SR, MDA_N

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK23, NCI-H209, SNU-719

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, A549, SK-N-SH

(see details)

RNA Interference


ADCK2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: BT549, TE9. (see details)