Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CAMKMT (Q7Z624) - Overview - Molecular Target Synopsis

Protein


CAMKMT, Calmodulin-lysine N-methyltransferase
Enzyme Classification 2.1.1.60
UniProt Q7Z624

Also Known as CMKMT_HUMAN, CAMKMT, C2orf34, CLNMT

Catalyzes the trimethylation of 'Lys-116' in calmodulin. Monomer (By similarity). Interacts with HSP90, probably as a client.

4PWY
CRYSTAL STRUCTURE OF A CALMODULIN-LYSINE N-METHYLTRANSFERASE FRAGMENT
RCSB/PDB
Inspect Structure
See all 3D Structures for CAMKMT

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CAMKMT is active in the following subcellular-locations: cytoplasm, golgi apparatus, nucleus.
GO terms: CAMKMT is active in the following subcellular-locations: cytoplasm, cytosol, Golgi apparatus, nucleus, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CAMKMT has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1599, SNU-719, IGROV-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, A549

(see details)

3D Structures


For CAMKMT there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis