Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DCXR (Q7Z4W1) - Overview - Molecular Target Synopsis

Protein


DCXR, L-xylulose reductase
Enzyme Classification 1.1.1.10
UniProt Q7Z4W1

Also Known as DCXR_HUMAN, DCXR, SDR20C1

Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. Homotetramer.

3D3W
STRUCTURE OF L-XYLULOSE REDUCTASE WITH BOUND COENZYME, PHOSPHATE AND HYDROXIDE.
RCSB/PDB
Inspect Structure
See all 3D Structures for DCXR

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: DCXR is active in the following subcellular-locations: membrane.
GO terms: DCXR is active in the following subcellular-locations: brush border, cytoplasmic microtubule, extracellular exosome, microvillus, nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DCXR has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, MCF7, HCT_116

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-157, YMB-1, Hep G2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, A549

(see details)

3D Structures


For DCXR there are:
3 structures (8 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


DCXR has been screened with 11 compounds (11 bioactivities). (see details)