Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRPM1 (Q7Z4N2) - Overview - Molecular Target Synopsis

Protein


TRPM1, Transient receptor potential cation channel subfamily M member 1
UniProt Q7Z4N2

Also Known as TRPM1_HUMAN, TRPM1, LTRPC1, MLSN, MLSN1

Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TRPM1 is active in the following subcellular-locations: cell membrane.
GO terms: TRPM1 is active in the following subcellular-locations: integral component of plasma membrane, new growing cell tip, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TRPM1 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: UACC_257, SK_MEL_28, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: 888, Hs 936.T, 624 mel

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to TRPM1 there are:
3 structures (12 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TRPM1 has been screened with compounds ( bioactivities). (see details)