Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ERAS (Q7Z444) - Overview - Molecular Target Synopsis

Protein


ERAS, GTPase ERas
UniProt Q7Z444

Also Known as RASE_HUMAN, ERAS, HRAS2, HRASP

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells. Interacts with PIK3CD.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
323ENSG00000187682ENST00000338270ENSP00000339136
233Q7Z444-1

Sub-cellular localization


UniProt: ERAS is active in the following subcellular-locations: cell membrane.
GO terms: ERAS is active in the following subcellular-locations: plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ERAS has gain in 1 cell-lines, loss in 61 cell-lines and no signal in 943 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Kasumi-1, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to ERAS there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ERAS has been screened with compounds ( bioactivities). (see details)