Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GRINA (Q7Z429) - Overview - Molecular Target Synopsis

Protein


GRINA, Protein lifeguard 1
UniProt Q7Z429

Also Known as LFG1_HUMAN, GRINA, LFG1, NMDARA1, TMBIM3

Potential apoptotic regulator.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GRINA is active in the following subcellular-locations: membrane.
GO terms: GRINA is active in the following subcellular-locations: endoplasmic reticulum, Golgi apparatus, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GRINA has gain in 12 cell-lines, loss in 2 cell-lines and no signal in 991 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, T47D, A498

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, HCC2911, HCC2279

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HMEC

(see details)


Screening and Chemistry


GRINA has been screened with compounds ( bioactivities). (see details)