Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC46A3 (Q7Z3Q1) - Overview - Molecular Target Synopsis

Protein


SLC46A3, Solute carrier family 46 member 3
UniProt Q7Z3Q1

Also Known as S46A3_HUMAN, SLC46A3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
463ENSG00000139508ENST00000380814ENSP00000370192Q7Z3Q1-2
461ENSG00000139508ENST00000266943ENSP00000266943Q7Z3Q1-1
386Q7Z3Q1-3

Sub-cellular localization


UniProt: SLC46A3 is active in the following subcellular-locations: membrane.
GO terms: SLC46A3 is active in the following subcellular-locations: extracellular exosome, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC46A3 has gain in 3 cell-lines, loss in 4 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, T47D, HCC_2998

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: TYK-nu.CP-r, TYK-nu, HCC2688

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, MCF-7, SK-N-SH

(see details)