Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

NRK (Q7Z2Y5) - Overview - Molecular Target Synopsis


NRK, Nik-related protein kinase
Enzyme Classification
UniProt Q7Z2Y5

Also Known as NRK_HUMAN, NRK

May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: NRK is active in the following subcellular-locations: cytoplasm.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project NRK has gain in 2 cell-lines, loss in 38 cell-lines and no signal in 965 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: ACHN, NCI_ADR_RES, HOP_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1568, NCI-H1915, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference

NRK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: DU4475, OVTOKO. (see details)

3D Structures

At greater than 50% identity similarity to NRK there are:
21 structures (48 chains) solved
19 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

NRK has been screened with compounds ( bioactivities). (see details)