Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NRK (Q7Z2Y5) - Overview - Molecular Target Synopsis

Protein


NRK, Nik-related protein kinase
Enzyme Classification 2.7.11.1
UniProt Q7Z2Y5

Also Known as NRK_HUMAN, NRK

May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: NRK is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NRK has gain in 2 cell-lines, loss in 38 cell-lines and no signal in 965 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: ACHN, NCI_ADR_RES, HOP_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1568, NCI-H1915, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


NRK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: DU4475, OVTOKO. (see details)

3D Structures


At greater than 50% identity similarity to NRK there are:
21 structures (48 chains) solved
19 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


NRK has been screened with compounds ( bioactivities). (see details)