Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

ectA (Q7W980) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed4
Chains with at least one site assessed as druggable using the strict criteria4
Chains with at least one site assessed as druggable using the relaxed criteria4


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3D3S_D L-2,4-diaminobutyric acid acetyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.22 71.2 37 Yes Yes
2 empty 2.51 63.5 15.9 No No
3 empty 2.63 63.8 15.5 No No
4 empty 2.72 76.5 11.3 No No
5 empty 1.95 57.2 12.4 No No
6 empty 2.32 64.6 11.3 No No
7 empty 2.35 65.5 9.8 No No
8 empty 2.69 63.6 8.7 No No
9 bound 1.67 68.3 9.1 No No
10 empty 2.03 74.7 6.3 No No
3D3S_A L-2,4-diaminobutyric acid acetyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 66.9 36.6 Yes Yes
2 empty 2.25 54 16.6 No No
3 empty 2.43 53.1 16.7 No No
4 empty 2.66 61.9 16.9 No No
5 bound 2.18 72.8 9.5 No No
6 empty 1.55 51.8 13.5 No No
7 empty 2.46 57.3 10 No No
8 empty 2.95 54.5 9.3 No No
9 empty 1.74 65.4 7 No No
10 empty 2.27 61.2 9.4 No No
3D3S_C L-2,4-diaminobutyric acid acetyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.18 71.2 19.4 Yes Yes
2 empty 1.92 61.8 20.8 No No
3 empty 1.89 53.4 18.4 No No
4 empty 2.48 57.5 10.6 No No
5 empty 2.16 62.3 10.6 No No
6 empty 1.42 59.1 12.5 No No
7 empty 2.18 63.9 8.6 No No
8 bound 2.19 72.8 9.8 No No
9 empty 1.72 62.8 8 No No
10 empty 2.23 62.9 9.4 No No
3D3S_B L-2,4-diaminobutyric acid acetyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 61.5 26.7 Yes No
2 bound 2.2 79 13 Yes Yes
3 empty 2.72 66.7 18.4 No No
4 empty 1.61 64.6 15.5 No No
5 empty 2.76 60.3 18 No No
6 empty 2.31 63 12.7 No No
7 empty 2.28 70.9 9.1 No No
8 empty 2.1 61.4 9.7 No No
9 empty 2.49 54.3 11.2 No No
10 empty 2.44 67.3 7.8 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed5
Domains assessed as druggable using the strict criteria3
Domains assessed as druggable using the relaxed criteria4

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3D3S_A (3350542) L-2,4-diaminobutyric acid acetyltransferase PFAM, PFAM, PFAM IPPT 1.87Å Yes Yes
3D3S_B (3350543) L-2,4-diaminobutyric acid acetyltransferase UNMATCHED, UNMATCHED, UNMATCHED 3D3S 1.87Å No No
3D3S_B (3350544) L-2,4-diaminobutyric acid acetyltransferase PFAM, PFAM, PFAM Acetyltransf_1 1.87Å Yes No
3D3S_C (4210710) L-2,4-diaminobutyric acid acetyltransferase UNMATCHED, UNMATCHED, UNMATCHED 3D3S HOMO 1.87Å Yes Yes
3D3S_A (4052578) L-2,4-diaminobutyric acid acetyltransferase UNMATCHED, UNMATCHED, UNMATCHED 3D3S HOMO 1.87Å Yes Yes
3D3S_D (4210710) L-2,4-diaminobutyric acid acetyltransferase UNMATCHED, UNMATCHED, UNMATCHED 3D3S HOMO 1.87Å Yes Yes
3D3S_B (4052578) L-2,4-diaminobutyric acid acetyltransferase UNMATCHED, UNMATCHED, UNMATCHED 3D3S HOMO 1.87Å Yes Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score