Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTA5 (Q7RTV2) - Overview - Molecular Target Synopsis

Protein


GSTA5, Glutathione S-transferase A5
Enzyme Classification 2.5.1.18
UniProt Q7RTV2

Also Known as GSTA5_HUMAN, GSTA5

Homodimer.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
222ENSG00000182793ENST00000370989, ENST00000284562ENSP00000360028, ENSP00000284562Q7RTV2-1

Sub-cellular localization


UniProt: GSTA5 is active in the following subcellular-locations: cytoplasm.
GO terms: GSTA5 is active in the following subcellular-locations: cytosol, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTA5 has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 90% identity similarity to GSTA5 there are:
15 structures (36 chains) solved
12 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

GSTA5 is solved in complex with the approved drug(s):

EAA/ETHACRYNIC ACID (1GSE_A, 1GSE_B, 1GSF_A, 1GSF_B, 1GSF_C, 1GSF_D).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTA5 has been screened with compounds ( bioactivities). (see details)