Molecular Target Synopsis
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glvI (Q7NDN8) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 10/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 10/09/2019)


Chains assessed551
Chains with at least one site assessed as druggable using the strict criteria109
Chains with at least one site assessed as druggable using the relaxed criteria522


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3IGQ_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.3 62.7 30.6 Yes No
2 empty 2.14 65.4 23.6 No No
3 empty 2.35 57.8 25.9 No No
4 empty 2.24 69.2 19.6 No No
5 empty 2.15 73.9 11.3 No No
6 empty 2.39 64.9 8.8 No No
7 empty 2.9 67.5 10.8 No No
8 empty 2.1 58.2 12.3 No No
9 empty 1.95 62.4 8.3 No No
10 empty 2.35 69.7 9.4 No No
5MVN_A Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 66.9 39.3 Yes Yes
2 bound 2.45 65.9 29.7 No No
3 empty 2.08 62.6 27 No No
4 empty 2.4 67.1 17.7 No No
5 empty 1.78 71.4 16.6 No No
6 empty 2.74 70 10 No No
7 empty 2.25 66.7 14.1 No No
8 empty 2.52 64.1 8.7 No No
9 empty 1.76 51.4 13.7 No No
10 bound 2 56.7 13.7 No No
5HEH_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 65 45.1 Yes No
2 empty 2.35 64.6 29.4 No No
3 empty 2.29 72.5 29.2 No No
4 empty 1.79 75.4 14 No No
5 empty 1.07 65.4 19.2 No No
6 empty 2.69 66.5 12.2 No No
7 empty 2.45 50 13.9 No No
8 empty 2.56 63.4 9.5 No No
9 empty 2.14 62.5 12.8 No No
10 empty 2.32 66.8 12 No No
5MZT_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 66.5 38 Yes Yes
2 bound 2.48 64.6 30.3 No No
3 empty 1.79 69 16.4 No No
4 empty 2.23 70.8 16.5 No No
5 empty .49 68.4 10.1 No No
6 empty 2.17 69.3 17.6 No No
7 empty 2.65 59.7 12.5 No No
8 empty 2.42 58.4 15 No No
9 bound 1.99 59.3 13.1 No No
10 empty 2.88 63.3 10.1 No No
6HYZ_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.2 65.3 26.8 Yes No
2 bound 2.2 61.4 27.4 No No
3 empty 2.1 62.7 23.8 No No
4 empty 1.63 71.3 13.6 No No
5 bound 1.05 66.3 20 No No
6 empty 2.12 71.2 18.2 No No
7 empty 2.49 62.3 25.5 No No
8 empty 2.43 62.6 14.4 No No
9 empty 2.68 66.4 13 No No
10 empty 2.38 61 11.9 No No
6F13_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 63.4 39.9 Yes No
2 bound 2.3 64 30.1 No No
3 empty 1.84 72.7 14.5 No No
4 empty 2.35 71 15.1 No No
5 bound 1.51 65.3 18.7 No No
6 empty 2.79 69.6 10.6 No No
7 empty 2.11 76.3 10.7 No No
8 bound 2.11 60 14.1 No No
9 empty 1.81 54.8 14.3 No No
10 empty 2.3 63.6 10.3 No No
6HYA_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 66.9 24.5 Yes No
2 empty 2.15 67.2 22 No No
3 empty 1.81 64.1 30 No No
4 empty 1.8 70.9 14.5 No No
5 empty .68 65.6 14.9 No No
6 empty 2.31 66.9 11.6 No No
7 empty 2.23 71.2 15.1 No No
8 empty 2.06 60.9 19.6 No No
9 empty 2.05 55.8 12.9 No No
10 empty 2.37 59.4 14.9 No No
6F10_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.4 63.9 36.1 Yes No
2 empty 1.86 61.5 39.1 No No
3 empty 2.13 64.4 27.3 No No
4 empty 1.83 69.8 17.5 No No
5 empty 2.22 66.9 14 No No
6 empty 1.93 59.4 13.7 No No
7 empty 2.53 68.3 9.6 No No
8 empty 2.21 56.5 11.9 No No
9 empty 2.39 66.4 7.1 No No
10 empty .45 68.2 10.5 No No
3UU4_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.46 64.1 34.9 Yes No
2 empty 2.24 63.9 32.1 No No
3 empty 2.32 64.2 27.8 No No
4 empty 2.18 63.9 23.8 No No
5 empty 1.65 71.7 11.7 No No
6 empty .68 63.8 15.9 No No
7 empty 2.53 53.6 18.1 No No
8 empty 2.23 55.7 11.9 No No
9 empty 2.65 65.6 10.9 No No
10 empty .39 62 11.6 No No
6F0M_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 64.2 43.7 Yes No
2 bound 2.39 64.7 29.4 No No
3 empty 2.1 64.1 26.9 No No
4 empty 1.77 71.8 17.5 No No
5 empty 2.32 67.5 22.2 No No
6 empty 2.07 72.9 16.6 No No
7 empty 2.6 65.6 9.8 No No
8 empty 2.21 59.4 12.4 No No
9 empty 1.68 59.3 11.9 No No
10 empty 2.36 64.8 13.4 No No
5HCM_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 63.4 33.3 Yes No
2 empty 1.52 72.4 34.3 Yes No
3 empty 2.43 66.1 29.9 No No
4 empty 2.26 73.9 13.6 No No
5 empty .47 67.2 17.8 No No
6 empty 2.63 63.9 11.5 No No
7 empty 2.08 72.5 15.1 No No
8 empty 2.16 58.8 15.9 No No
9 empty 2.32 61.1 9.1 No No
10 empty 2.35 63.8 8.1 No No
6F0I_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.4 64.3 28.6 Yes No
2 empty 1.87 63.9 38.4 No No
3 empty 2.18 63.9 27 No No
4 empty 1.84 72.1 16.4 No No
5 empty 2.24 67.4 21 No No
6 empty .74 62.6 18 No No
7 empty 2.06 74.7 15.9 No No
8 empty 2.56 65.7 12.1 No No
9 empty 2.23 60.2 11.2 No No
10 empty 1.79 57.6 12.9 No No
6I08_D Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 No No
2 No No
3 No No
4 No No
5 No No
6 No No
7 No No
8 No No
9 No No
10 No No
6F0U_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 63.6 39 Yes No
2 bound 2.48 66.1 27.8 No No
3 empty 2.15 64.7 26.9 No No
4 empty 1.78 72.5 18.4 No No
5 empty 2.28 63.7 20.1 No No
6 bound .68 62.2 17.7 No No
7 empty 2.07 75.5 15.3 No No
8 bound 1.95 60.3 11.8 No No
9 empty 2.62 68.3 11.6 No No
10 empty 2.17 54.6 11.9 No No
2XQ7_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 64.8 39.4 Yes No
2 empty 2.34 65.2 29.8 No No
3 empty 2.43 64 30 No No
4 empty 1.8 77.2 12.9 No No
5 empty 2.52 68.4 11.3 No No
6 empty 2.77 64.8 12.1 No No
7 empty 2.18 74.3 11.1 No No
8 empty 2.26 63.8 14.4 No No
9 empty 2.22 64.1 11.2 No No
10 empty .33 63.1 12.2 No No
3UUB_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.43 63.7 34.6 Yes No
2 bound 1.97 64.7 36.4 No No
3 empty 1.98 61 24.9 No No
4 empty 1.9 75.4 11.5 No No
5 empty 2.17 64.9 20 No No
6 empty 2.31 72.1 22.5 No No
7 empty .44 67.4 12.2 No No
8 empty 2.8 68.6 12.1 No No
9 empty 2.29 57.2 11.1 No No
10 empty 2.52 65.1 13.1 No No
6HJZ_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.4 66.7 29.4 Yes No
2 empty 1.96 60.8 31 No No
3 empty 2.1 63.5 26.3 No No
4 empty 1.83 69.9 19.3 No No
5 empty 2.33 67.4 19.9 No No
6 bound .68 71.7 20 No No
7 empty 2.05 73.7 17.6 No No
8 empty 2.68 70.2 10 No No
9 empty 1.99 59.9 10.9 No No
10 empty 2.48 58.2 12 No No
5MUR_A Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 66.1 39.1 Yes Yes
2 bound 2.47 66.2 27.9 No No
3 empty 2.01 62.9 25 No No
4 empty 1.85 72.9 15 No No
5 empty 2.46 66.3 12.7 No No
6 empty 2.71 71 11.1 No No
7 empty 2.36 59.7 11.8 No No
8 empty 2.53 64.1 8.1 No No
9 empty 2.04 64.9 14.8 No No
10 empty 1.97 59.5 12 No No
4ILC_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.47 65.5 29.5 Yes No
2 bound 1.95 61.5 34.5 No No
3 empty 2.09 64.6 26.7 No No
4 empty 1.9 75.1 13.1 No No
5 empty 2.41 71.1 13.6 No No
6 bound .72 71.8 11.7 No No
7 empty 2.17 69.3 18.4 No No
8 empty 2.71 68.2 9.6 No No
9 bound 1.97 58 15.7 No No
10 empty 1.81 50.8 13.3 No No
5NJY_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.36 65.6 28.4 Yes No
2 empty 2.09 68.8 19.9 No No
3 empty 2.25 62.2 25.5 No No
4 empty 2.22 70.5 13.5 No No
5 empty 1.87 67.3 13.5 No No
6 empty 1.41 68.2 15.1 No No
7 empty 2.29 58.2 12.1 No No
8 empty 2.59 62.9 10.5 No No
9 empty .46 67 12.7 No No
10 empty 2.25 59.5 14 No No
6HZ0_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 64.1 28.5 Yes No
2 empty 2.35 62.2 28.1 No No
3 empty 1.83 71.2 12.5 No No
4 empty 1.5 66.9 20.6 No No
5 empty 2.17 69.5 22.7 No No
6 bound .69 64.5 17 No No
7 empty 2.42 59 15.6 No No
8 empty 2.53 63.2 10.8 No No
9 empty 2.68 65.5 12 No No
10 empty 2.19 67.8 17.5 No No
3UU4_A Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 66.9 42.8 Yes Yes
2 empty 2.47 64.7 34 No No
3 empty 2.2 61.1 27.7 No No
4 empty 2.07 66.4 13.5 No No
5 empty .72 67.4 12.8 No No
6 empty 1.99 75.8 11.3 No No
7 empty .36 65.4 13.8 No No
8 empty 2.56 71.6 9.9 No No
9 empty 2.22 59.9 14.5 No No
10 empty 2.13 56.2 11.7 No No
4ILB_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.43 67.4 28.9 Yes No
2 bound 2.11 60.7 26.8 No No
3 empty 2.25 72.1 25.3 No No
4 empty 2.09 63.3 26.2 No No
5 empty 1.8 70.5 17.3 No No
6 bound .71 66.2 13.4 No No
7 empty .46 68.3 11.5 No No
8 empty 2.71 68.1 9.6 No No
9 bound 2.03 59 13.7 No No
10 empty 2.38 65.8 9.2 No No
5L4H_D Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 72 30.9 Yes Yes
2 empty 2.25 69.5 22.2 No No
3 empty 2.25 64 25.9 No No
4 empty .84 73.3 17.9 No No
5 empty 2.24 69.4 22.5 No No
6 empty .5 66.9 17 No No
7 empty 2.7 67.4 11 No No
8 empty 2.46 61.6 13.1 No No
9 empty 2.41 61.4 12.2 No No
10 empty 2.13 59.9 12.4 No No
6F0R_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 64.5 35.5 Yes No
2 bound 2.17 65.8 28.3 No No
3 empty 1.79 71.3 17.1 No No
4 empty 2.28 63.4 27.7 No No
5 empty 2.46 65.3 22.8 No No
6 empty 2.3 68.3 17.1 No No
7 empty 1.97 71.4 17.4 No No
8 empty 2.11 55.7 13.3 No No
9 empty 2.45 64.7 13.4 No No
10 empty 2.11 59.7 14 No No
4NPQ_N Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 67.8 28.4 Yes Yes
2 empty 2.21 64.8 30.9 No No
3 empty 2.1 61.9 29.5 No No
4 empty 1.9 90.8 18.2 Yes No
5 empty .96 71.8 19.1 No No
6 empty 2.26 63 24.7 No No
7 empty 1.64 68.1 17 No No
8 empty .34 62.4 17.5 No No
9 empty 2.33 57.7 11.3 No No
10 empty 2.33 66.2 11.6 No No
6EMX_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.39 64 34.5 Yes No
2 empty 1.91 63 40.6 No No
3 empty 2.09 62.6 27.4 No No
4 empty 1.77 72.6 15.4 No No
5 bound .73 73.7 18.7 No No
6 empty 2.41 65.9 22.2 No No
7 empty 2.62 72.4 10.3 No No
8 empty 2.55 63.8 17.3 No No
9 empty 2.3 62.7 20.9 No No
10 empty 2.29 59.3 12.8 No No
5NKJ_A Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 68.4 33.4 Yes Yes
2 empty 2.38 64.8 29.8 No No
3 empty 2.24 64.3 26.8 No No
4 empty 1.92 66.4 18.3 No No
5 empty 2.23 57.9 25.5 No No
6 empty 2.36 60.6 16.5 No No
7 empty .57 66.2 20 No No
8 empty 1.98 60.5 15.3 No No
9 empty 2.77 71 10.5 No No
10 empty 1.96 62.3 12.8 No No
2XQA_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 64.1 32.9 Yes No
2 empty 2.31 64.5 30 No No
3 empty 2.31 70.3 16.3 No No
4 empty 1.82 78.1 13.7 No No
5 empty 1.17 65.9 19.3 No No
6 empty 2.13 50.9 17.5 No No
7 empty 2.49 61.2 12.4 No No
8 empty 2.5 62.8 12.3 No No
9 empty 2.08 60.7 13.7 No No
10 empty .45 67.4 11.9 No No
4QH4_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 65 43.7 Yes No
2 empty 2.36 63.9 28.3 No No
3 empty 2.39 64.6 28.6 No No
4 empty 1.76 74.5 13.1 No No
5 empty 2.55 61 12.6 No No
6 empty 1.81 59.5 12.3 No No
7 empty 2.93 61.4 13.9 No No
8 empty 2.84 71.1 9 No No
9 empty 2.23 58.9 11.8 No No
10 empty 2.27 78.9 9 No No
5L4E_A Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 67.6 47.2 Yes Yes
2 empty 2.5 64.7 34.9 No No
3 empty 2.23 71.5 11.8 No No
4 empty 2.45 62 16.8 No No
5 empty 2.28 60.9 11.1 No No
6 empty 2.39 54.7 10.7 No No
7 empty 2.81 69.6 8.6 No No
8 empty 2.03 62.8 11.5 No No
9 empty .44 71.4 8.2 No No
10 empty 2.37 61.4 8.5 No No
5OSA_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.24 65.8 30.7 Yes No
2 empty 2.1 67.9 18.8 No No
3 empty 2.4 69.4 20.5 No No
4 empty 2.24 61.8 15.3 No No
5 empty 2.66 55 18.1 No No
6 empty 2.14 57.6 17.6 No No
7 empty 1.99 73 14.7 No No
8 empty 2.76 72.8 9.6 No No
9 empty 2.15 62.2 11.6 No No
10 empty 2.43 60.2 18.4 No No
6HY5_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 63.7 39.9 Yes No
2 bound 2.4 64.3 34 No No
3 empty 2.25 71.3 31.7 No No
4 empty 1.75 75.7 15.8 No No
5 empty 1.83 65 18.8 No No
6 empty 2.62 72.1 11.1 No No
7 empty 2.41 60.2 13.6 No No
8 empty 1.77 63.9 11.5 No No
9 empty 2.4 58.6 11.7 No No
10 empty 2.84 66.7 9.2 No No
3UUB_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 62.4 35.3 Yes No
2 empty 2.54 65.6 30.3 No No
3 empty 2.03 64.7 26.6 No No
4 empty 1.79 69.5 17.6 No No
5 empty 2.24 70.2 17.8 No No
6 empty .44 66.8 18.1 No No
7 empty 2.76 69.3 9.4 No No
8 empty 2.57 59.4 19.2 No No
9 empty 2.27 54.4 13.8 No No
10 empty 2.37 58.6 11.9 No No
4IL9_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.23 62.9 34.3 Yes No
2 bound 2.29 65.8 28.3 No No
3 empty 1.83 69.4 16.5 No No
4 empty 2.33 65.4 19.5 No No
5 empty 2.31 60.1 14.4 No No
6 empty 2.23 68.1 18.4 No No
7 empty 2.53 69.9 9.6 No No
8 bound .74 63.1 13.3 No No
9 empty .48 67.4 11.9 No No
10 empty 2.3 54.4 13.2 No No
4ZZC_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.14 63.6 42.9 Yes No
2 bound 2.4 64.8 30 No No
3 empty 1.75 73.1 17.5 No No
4 empty 2.38 68.3 17.6 No No
5 bound .73 71 17.8 No No
6 empty 2.53 67.5 10.7 No No
7 empty 2 70.8 15.3 No No
8 empty 2.01 59.4 14.4 No No
9 empty 2.35 56.8 11.7 No No
10 empty 1.88 55.9 15.1 No No
6F12_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.45 64.3 34.2 Yes No
2 empty 1.87 65.2 43.6 No No
3 empty 2.11 61.8 26.1 No No
4 empty 1.83 70.6 18.1 No No
5 empty 2.25 68.7 15.9 No No
6 empty 1.49 63.9 19 No No
7 empty 1.66 57.6 13.6 No No
8 empty 2.3 56.3 11.9 No No
9 empty 2.58 63.8 12.5 No No
10 empty 2.21 65.1 8.4 No No
6F16_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 62.8 49 Yes No
2 bound 2.36 64.3 33 No No
3 empty 1.81 72.4 16.9 No No
4 empty 2.25 66.3 24 No No
5 empty 2.08 76.5 17 No No
6 bound .75 65.2 14.4 No No
7 empty 2.42 55.5 12.4 No No
8 empty 2.61 67.3 10.2 No No
9 empty 1.67 59.7 15 No No
10 empty 2.36 66 7.8 No No
5OSC_B Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.2 64.9 23.1 No No
2 empty 2.13 69.3 23.2 No No
3 empty 2.08 62.2 21.6 No No
4 empty 2.27 64.2 19.8 No No
5 empty 2.08 58.3 16.2 No No
6 empty 2.08 61.4 18 No No
7 empty 2.11 75 13.7 No No
8 empty 2.5 56.9 15.4 No No
9 empty 2.77 67 11.6 No No
10 empty 2.69 64.1 11.1 No No
6F0V_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.35 62.7 30.1 Yes No
2 empty 1.91 62.6 37.5 No No
3 empty 2.12 64.6 26.6 No No
4 empty 1.78 69.8 18.6 No No
5 empty 2.22 66.3 15.3 No No
6 empty .71 70.5 14.7 No No
7 empty 2.07 73.2 11.3 No No
8 empty 1.72 58.4 14.8 No No
9 empty 2.58 68.7 13.4 No No
10 empty 2.23 65 11.9 No No
5HEG_D Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 67.5 36 Yes Yes
2 empty 2.38 65.3 30 No No
3 empty 1.97 62.1 30.9 No No
4 empty 1.04 72.5 18.6 No No
5 empty 2.31 71.1 22.7 No No
6 empty 2.38 64.1 16.5 No No
7 empty 2.34 53.2 13.7 No No
8 empty .46 70.2 10.1 No No
9 empty 2.13 62.6 12.2 No No
10 empty 2.87 71.3 9.1 No No
4NPQ_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 68.9 27.4 Yes No
2 empty 2.3 68.7 35.7 No No
3 empty 2.21 63.4 28.5 No No
4 empty 1.77 67.4 16.4 No No
5 empty 2.02 68.7 21.5 No No
6 empty 1.6 67.7 19.9 No No
7 empty .64 72.7 17.2 No No
8 empty 2.19 64.9 22.3 No No
9 empty 1.91 77.7 10.9 No No
10 empty .37 61.8 13 No No
5MZR_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.05 63 42.3 Yes No
2 bound 2.41 64.9 29.1 No No
3 bound .69 78.1 16.8 No No
4 empty 1.66 63.9 16.4 No No
5 empty 2.4 69.7 16.2 No No
6 empty 2.21 64.5 13.8 No No
7 empty 2.68 63.4 12.5 No No
8 empty 2.07 78.7 11.3 No No
9 empty 2.57 60.9 16.3 No No
10 empty 2.4 62 11.6 No No
6HJA_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.44 64.6 32.9 Yes No
2 bound 2.18 61.3 26.7 No No
3 empty 2.03 62.7 26.9 No No
4 empty 1.79 69.6 16.3 No No
5 empty 2.09 73 16.3 No No
6 bound .71 72.5 15.6 No No
7 empty .33 68.5 16 No No
8 empty 2.71 71.5 9.1 No No
9 empty 2.33 64.7 18.9 No No
10 empty 2.32 55.9 12.8 No No
5MUO_B Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 66.9 37.4 Yes Yes
2 bound 2.45 64.2 35.8 No No
3 empty 2.01 71.2 13.2 No No
4 empty .38 69.6 15.8 No No
5 empty 2.64 62.2 12.5 No No
6 empty 2.39 61.6 12.4 No No
7 empty 2.29 58.8 10.5 No No
8 empty 2.12 64.5 12.2 No No
9 empty 2.58 53 9.1 No No
10 empty 1.19 65.1 10 No No
6F10_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.32 65.1 29.5 Yes No
2 empty 2.03 62 40.6 No No
3 empty 1.96 63.1 25.2 No No
4 empty 1.81 73 16.3 No No
5 empty 2.25 68 19.7 No No
6 empty 2.49 59.9 16.2 No No
7 empty .73 70.3 16.9 No No
8 empty 1.99 60.5 13.6 No No
9 empty 1.85 54.5 14.8 No No
10 empty 2.67 64.7 10.5 No No
4QH1_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 64.2 39.5 Yes No
2 bound 2.24 66.5 23.3 No No
3 empty 1.84 75.9 12 No No
4 empty 2.44 66.1 22.8 No No
5 empty .71 65.4 14.9 No No
6 empty 2.47 61.2 14.4 No No
7 empty 2.12 74.6 10.8 No No
8 empty 2.53 62.9 12.2 No No
9 empty 1.96 62.2 13.5 No No
10 empty 2.32 55 15.5 No No
6HZ1_E Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 No No
2 No No
3 No No
4 No No
5 No No
6 No No
7 No No
8 No No
9 No No
10 No No
5HCJ_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 65.6 33.2 Yes No
2 empty 1.93 67 37.2 No No
3 empty 2.39 67.2 27.8 No No
4 empty 1.95 73.4 16.4 No No
5 empty .55 65.4 19.7 No No
6 empty 2.76 70.9 9.6 No No
7 empty 2.23 67.6 15.1 No No
8 empty 2.68 61.8 15.1 No No
9 empty 1.86 64.1 12.8 No No
10 empty 2.32 61.8 11.2 No No
4HFB_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.29 61.4 32.1 Yes No
2 bound 2.36 64.1 35.3 No No
3 empty 1.77 67 20.3 No No
4 empty 2.36 70.9 18.4 No No
5 bound .68 74.6 15.6 No No
6 empty 2.24 78.8 12.6 No No
7 empty 2.65 65.2 13.2 No No
8 empty .49 67.5 18.8 No No
9 empty 2.61 55.6 11.5 No No
10 empty 1.76 52.4 15.7 No No
6F15_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.18 61 49.9 Yes No
2 bound 2.41 66.8 29.5 No No
3 empty 1.79 71.6 16 No No
4 empty 2.22 67.2 17.9 No No
5 bound .69 72.5 14.9 No No
6 empty 2.26 52.9 12.9 No No
7 bound 1.98 60.9 12.6 No No
8 empty 1.68 60.1 13.1 No No
9 empty 2.15 76.2 10.3 No No
10 empty 2.55 68.9 9.9 No No
4NPQ_J Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 69.9 30.9 Yes Yes
2 empty 2.26 65.2 29.5 No No
3 empty 2.11 65.4 28.2 No No
4 empty 2.03 68.7 17.9 No No
5 empty .66 74.8 14.7 No No
6 empty 1.62 71.7 12 No No
7 empty 1.37 98.7 0 Yes No
8 empty 1.74 63.9 16.8 No No
9 empty 1.99 72.3 13.3 No No
10 empty 2.2 65.2 14.4 No No
3UU8_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.43 65.1 30 Yes No
2 bound 1.96 63.1 39.8 No No
3 empty 2.15 63.9 26.9 No No
4 empty 1.72 72.7 13.1 No No
5 empty 2.32 69 14.4 No No
6 bound .84 63.4 14 No No
7 empty 2.1 58.2 14.7 No No
8 empty 2.26 59.2 10.9 No No
9 empty 2.65 75.4 7.9 No No
10 empty 2.38 62.1 12.4 No No
3P4W_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 63.2 46.4 Yes No
2 empty 2.28 66.8 28.1 No No
3 empty 2.12 67.1 25.1 No No
4 empty 1.77 72.4 18.8 No No
5 empty 2.4 68.5 18.9 No No
6 bound .76 76.3 15.3 No No
7 empty 2.71 63.8 12.2 No No
8 empty 2.12 74.5 15.5 No No
9 empty 1.9 62 13.3 No No
10 empty 1.73 49.9 14.4 No No
4HFE_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 63.3 41.7 Yes No
2 bound 2.35 64.4 24.7 No No
3 empty 1.75 71.5 15.7 No No
4 bound 1.26 69 19.2 No No
5 empty 2.35 68.6 11 No No
6 empty 2.11 77.4 12.1 No No
7 empty 2.63 66.5 12.7 No No
8 empty 1.81 59.2 13.7 No No
9 empty 2.41 60.8 15.2 No No
10 empty 2.37 65.6 8.4 No No
4HFC_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 65.2 43.4 Yes No
2 empty 2.36 66.9 29.6 No No
3 empty 1.82 70.1 17.5 No No
4 empty 2.62 56.8 16.8 No No
5 empty .37 65.8 18.7 No No
6 empty 2.69 69.4 9.7 No No
7 empty 1.95 67.4 12 No No
8 empty 2 60.8 13.5 No No
9 empty 1.99 62.1 15.1 No No
10 empty 2.23 64.5 9 No No
3TLS_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 66.7 36.6 Yes Yes
2 empty 2.27 64.8 27.4 No No
3 empty 2.43 63.8 32.2 No No
4 empty 1.72 61.7 23.5 No No
5 empty 2.34 58.6 14.9 No No
6 empty 2.62 69.1 10.4 No No
7 empty 2.38 58.3 10.5 No No
8 empty .42 66.5 9.4 No No
9 empty 2.43 64 13.1 No No
10 empty .88 60.4 9.6 No No
4HFD_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 64.4 43.9 Yes No
2 bound 2.38 67.1 29.7 No No
3 empty 2.26 72.4 25.4 No No
4 empty 1.79 68.6 17.9 No No
5 bound .71 71.1 12.3 No No
6 empty 2.69 69 13 No No
7 bound 1.99 59.9 13.1 No No
8 empty 2.24 66.5 7.8 No No
9 empty 2.52 55.5 11.2 No No
10 empty .41 61.8 13.9 No No
6F0R_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 66.5 43.4 Yes Yes
2 bound 2.22 66.5 21.7 No No
3 empty 2.13 61.9 25 No No
4 empty 1.86 76.2 11.9 No No
5 empty 2.38 70.5 19.5 No No
6 bound 2.06 58.3 15.4 No No
7 empty 2.38 65.5 14.8 No No
8 empty 2.24 55.3 12.1 No No
9 empty 2.39 58.6 14.6 No No
10 empty 1.89 55 15.3 No No
6F0M_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 63.4 39.9 Yes No
2 bound 2.4 66.2 29.4 No No
3 empty 2.15 63.5 26.3 No No
4 empty 1.78 68.5 17.3 No No
5 empty 2.25 69.5 21.5 No No
6 empty 2.09 72.3 15.8 No No
7 empty 2.61 64.7 10 No No
8 bound 1.94 62.1 11.4 No No
9 empty 2.18 56 12.1 No No
10 empty 1.65 60.6 13.1 No No
6HJ3_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.31 64.7 33.8 Yes No
2 bound 1.79 61.7 39 No No
3 empty 2.13 64.3 26.5 No No
4 empty 1.79 73.6 16.2 No No
5 empty 2.44 70 18.1 No No
6 bound .79 62.9 15.5 No No
7 empty 2.73 69.5 12 No No
8 empty 2.34 59.6 11.2 No No
9 empty 2.4 57 13.2 No No
10 empty 1.88 56.8 13.8 No No
3UUB_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 64 38.9 Yes No
2 empty 2.47 63.7 34.9 No No
3 empty 2.04 65.2 26.7 No No
4 empty 1.76 68.6 17.3 No No
5 empty 2.37 68 21.1 No No
6 empty 2.27 66.9 19.2 No No
7 empty 2.8 71.6 8.9 No No
8 empty 2.28 60.2 11 No No
9 empty 2.67 60.1 11.5 No No
10 empty 1.85 57.3 13.6 No No
4NPQ_F Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 65.3 38 Yes No
2 empty 2.14 65.4 32.2 No No
3 empty 2.03 62.8 24.3 No No
4 empty .64 70.4 16.6 No No
5 empty 1.75 72.1 13.3 No No
6 empty 2 60.5 19.2 No No
7 empty 1.76 77.9 12.2 No No
8 empty 2.38 61.2 14.5 No No
9 empty .36 63.4 15.1 No No
10 empty 1.6 99.2 0 Yes No
2XQ6_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 64.2 33.2 Yes No
2 empty 2.37 67.9 27.9 No No
3 empty 1.68 77 11.8 No No
4 empty 2.35 67.2 22.7 No No
5 empty 1.14 65.1 23.2 No No
6 empty 2.17 44.8 17.5 No No
7 empty 2.44 61.8 17.6 No No
8 empty 2.78 69.7 9 No No
9 empty .63 68.9 9.4 No No
10 empty 2.37 66.7 11.9 No No
5MUO_A Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 68.4 37.5 Yes Yes
2 bound 2.32 65.9 33 No No
3 empty 2.09 62.5 24.4 No No
4 empty 1.45 71.4 24.5 No No
5 empty 2.24 67.2 14.4 No No
6 empty .36 66.8 19.1 No No
7 empty 2.82 74.7 10.4 No No
8 empty 2.23 55.5 11.8 No No
9 empty 2.7 64.5 7.6 No No
10 empty 2.03 64.4 12.8 No No
5MZR_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 68.5 36.3 Yes Yes
2 bound 2.39 63.4 32.9 No No
3 empty 2.11 63.1 25.9 No No
4 empty 1.65 67.1 16.9 No No
5 empty 2.21 70.6 15 No No
6 empty 2.3 69.1 18.5 No No
7 empty 2.53 62.8 12 No No
8 empty 2.4 60.8 12.6 No No
9 empty 2.62 63.3 9.9 No No
10 empty 1.81 53.3 14 No No
3UU8_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.43 64.5 34.2 Yes No
2 empty 2.13 61.9 27.1 No No
3 bound 2.05 60.9 27 No No
4 empty 1.72 70.9 15.2 No No
5 empty 2.24 63.3 18.5 No No
6 empty 2.19 70 17.8 No No
7 empty .46 66.5 18.4 No No
8 bound .86 62.6 12.6 No No
9 empty 2.33 54.5 12 No No
10 empty 2.28 62.8 10.3 No No
4HFC_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.4 65.9 33.6 Yes No
2 bound 1.83 67.8 31.6 No No
3 empty 2.03 66.7 25.8 No No
4 empty 1.81 68.5 17.7 No No
5 empty 2.73 71.2 11.9 No No
6 empty .47 68.2 17.3 No No
7 empty 1.84 71 11 No No
8 empty 2.31 76.9 14.9 No No
9 empty 2.3 61 9 No No
10 empty 2.43 54 12.3 No No
6HJA_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.46 66.3 34.7 Yes No
2 bound 1.91 62.6 37.3 No No
3 empty 2.11 67.4 26.2 No No
4 empty 1.76 70.3 18.5 No No
5 empty 2.35 66.5 14.4 No No
6 bound .73 65.5 15.6 No No
7 empty 2.29 56.9 13.9 No No
8 empty 2.33 65 18.5 No No
9 empty 1.8 57.4 13.6 No No
10 empty 2.71 72.4 8.1 No No
6I08_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 66.2 37.9 Yes Yes
2 empty 2.42 68.5 35 No No
3 empty 2.12 62.7 21.9 No No
4 empty 2.37 69.9 16.6 No No
5 empty .46 70 11.7 No No
6 empty 2.16 62.2 12.3 No No
7 empty 2.27 62.4 10.3 No No
8 empty 2.41 60.5 12 No No
9 empty 2.53 51.8 10.2 No No
10 empty .37 64.5 10.5 No No
5L4E_E Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 69.9 35.5 Yes Yes
2 empty 1.96 64.9 37.4 No No
3 empty 2.32 65.2 28.2 No No
4 empty 2.14 70.1 17.2 No No
5 empty .52 68 17.5 No No
6 empty 2.74 68.9 9.8 No No
7 empty 2.3 62.9 12.2 No No
8 empty 2.44 61.5 13.8 No No
9 empty 2.24 56 13.9 No No
10 empty 2.11 64.6 8.8 No No
3UU5_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.53 64.7 32 Yes No
2 bound 1.94 63.8 36.9 No No
3 empty 1.9 64.8 18.8 No No
4 empty 1.85 66.7 19.6 No No
5 bound .75 69.5 13.1 No No
6 empty 2.19 73.7 15.4 No No
7 empty 1.87 78 10.5 No No
8 empty 2.67 71 9.9 No No
9 empty 2.28 58 11.9 No No
10 empty 2.37 66.3 7.8 No No
6F0J_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.76 63.9 36.4 Yes No
2 bound 2.44 63.5 34.9 No No
3 empty 2.01 64.5 24.5 No No
4 empty 1.88 73.9 12.3 No No
5 empty 2.19 70.2 22.8 No No
6 empty 1.9 70.2 16.1 No No
7 empty 2.63 63.6 12.4 No No
8 empty 1.75 58.1 14 No No
9 empty 2.23 61.4 11.7 No No
10 empty 2.74 62.4 8 No No
4NPQ_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 65.6 34.9 Yes No
2 empty 2.18 64.8 30.7 No No
3 empty 2.06 67.7 23.2 No No
4 empty 1.06 69.4 20.8 No No
5 empty 1.72 67.1 14.8 No No
6 empty 2.11 72.4 16.8 No No
7 empty 2.38 57.5 15.1 No No
8 empty .36 64.4 15.4 No No
9 empty 2.48 66.4 14.4 No No
10 empty 2.25 61.4 11.6 No No
5V6N_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 65 47.6 Yes No
2 empty 2.26 65 26.7 No No
3 empty 2.29 71.2 32.6 No No
4 empty 1.79 73.3 14.6 No No
5 empty .63 72.2 18.1 No No
6 empty .84 68.7 12 No No
7 empty 2.8 75 9.3 No No
8 empty 2.48 66.5 10.8 No No
9 empty 2.76 64.8 12.2 No No
10 empty .45 58.9 11.5 No No
2XQ7_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 65.4 29.5 Yes No
2 empty 2.05 64 42.9 No No
3 empty 2.34 65.2 30.9 No No
4 empty 2.31 65.4 27.7 No No
5 empty 1.69 81.2 13 No No
6 empty 2.5 65.7 11.1 No No
7 empty 2.74 66.5 12.4 No No
8 empty 2.2 71.4 11.4 No No
9 empty .34 66.3 9.8 No No
10 empty .39 67.8 11.3 No No
6HYA_B Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 No No
2 No No
3 No No
4 No No
5 No No
6 No No
7 No No
8 No No
9 No No
10 No No
4QH5_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.48 67.4 35.2 Yes No
2 empty 2.13 64.9 26.4 No No
3 empty 1.87 73.7 16.8 No No
4 empty 2.41 61.5 26.5 No No
5 empty 1.6 65.4 18.7 No No
6 empty 2.35 69.6 15.5 No No
7 empty 2.33 66.9 18 No No
8 empty .75 63.9 13 No No
9 empty 1.76 57.7 14.7 No No
10 empty 2.27 60.1 15.9 No No
4ILA_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.4 63.1 34.2 Yes No
2 bound 1.87 62 39.5 No No
3 empty 2.2 63.2 26.3 No No
4 empty 1.7 73.2 14.7 No No
5 empty 2.42 67.5 18.3 No No
6 bound .7 71.3 17.7 No No
7 empty 2.12 71.5 18.9 No No
8 empty 2.54 63.4 12.2 No No
9 empty 2.49 61.6 11.9 No No
10 empty 2.19 55.6 11.1 No No
6F0I_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.51 64.8 34.3 Yes No
2 empty 1.97 63.1 32.9 No No
3 empty 2.13 64.8 27.2 No No
4 empty 1.77 69.6 16.4 No No
5 empty 2.21 69.6 21.2 No No
6 empty .78 64.8 11.2 No No
7 empty 2.64 65.9 10.2 No No
8 empty 1.8 58.1 14.8 No No
9 empty 2.38 59.3 11.8 No No
10 empty 2 70.2 13.1 No No
5HCM_A Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.93 66.6 39.7 Yes Yes
2 empty 2.46 65.7 33.7 No No
3 empty 2.13 65 26 No No
4 empty 2.25 65.9 14.3 No No
5 empty .34 64.6 21.3 No No
6 empty 2.71 73.9 9.7 No No
7 empty 2.13 73.1 15.1 No No
8 empty 2.33 56.7 13.5 No No
9 empty 2.61 66.5 8.3 No No
10 empty 2.28 61 11.9 No No
5L47_A Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 66.7 36.5 Yes Yes
2 bound 2.21 70.1 20.6 No No
3 empty 2.39 70 12.8 No No
4 empty .96 72.8 17.2 No No
5 empty 2.64 67.6 10.1 No No
6 empty 2.32 63.1 15.3 No No
7 empty 2.35 64.6 14.3 No No
8 empty 2.16 61.4 12.2 No No
9 empty 2.68 66.2 7 No No
10 empty 2.33 67.2 10.6 No No
3P4W_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.44 64.8 36 Yes No
2 bound 1.9 62.5 40.5 No No
3 empty 2.16 66.8 26.8 No No
4 empty 1.78 71.9 15.8 No No
5 bound .76 72.1 20.3 No No
6 empty 2.34 68.1 20.9 No No
7 empty 2.31 66.3 18.9 No No
8 empty 2.54 66.8 9.8 No No
9 empty 2.23 66.8 12.3 No No
10 empty 2.25 78.1 7.1 No No
6HZ1_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 63.5 45.5 Yes No
2 bound 2.49 62.2 34.9 No No
3 empty 1.56 68.9 16.4 No No
4 bound .71 64.6 13.2 No No
5 empty 1.95 76.1 9.2 No No
6 empty 2.19 75.4 12.3 No No
7 empty 2.69 66.1 12.8 No No
8 empty 2.38 61.9 10.4 No No
9 empty 2.38 66.4 8.8 No No
10 empty 2.48 55.3 10.5 No No
3P50_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 65.5 38.1 Yes No
2 empty 2.31 64.3 32 No No
3 empty 2.17 64.2 26.9 No No
4 empty 1.79 74.5 15.5 No No
5 empty 2.17 62.4 19.3 No No
6 empty 2.4 68 20 No No
7 empty 2.66 70.9 9.5 No No
8 empty 2.52 56.5 12.3 No No
9 empty 2.26 63 10.4 No No
10 empty 1.84 51.7 13.8 No No
5MVN_B Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 67.8 31.8 Yes Yes
2 bound 2.44 63.6 34.6 No No
3 empty 1.94 64.1 25.5 No No
4 empty 1.76 69.5 15.7 No No
5 empty 2.43 70.5 15.1 No No
6 empty 2.73 70.8 11.7 No No
7 empty 2.47 65.9 11.3 No No
8 empty 2.28 68.9 13.4 No No
9 empty 1.69 54.7 14.6 No No
10 empty 2.42 58.5 11.5 No No
4LMJ_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 65.1 40 Yes No
2 empty 2.23 67.6 24.2 No No
3 empty 2.21 71 21 No No
4 empty .87 69.1 13.7 No No
5 empty 2.49 63.1 12.2 No No
6 empty 2.47 65.3 9.8 No No
7 empty 2.46 55.8 13.3 No No
8 empty 2.11 61.6 8.5 No No
9 empty 2.29 60.6 8.2 No No
10 empty .35 63.6 11.1 No No
4NPQ_M Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.28 65.3 36.9 Yes No
2 empty 2.37 65.4 28.7 No No
3 empty 1.71 79.8 18.1 No No
4 empty 2.05 71.1 15.9 No No
5 empty .64 76 15.6 No No
6 empty 1.82 69.4 13.7 No No
7 empty 1.59 67.9 18.5 No No
8 empty 1.9 68.1 17.9 No No
9 empty 1.85 75.6 11.1 No No
10 empty .38 65.6 13.3 No No
5V6N_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 66.4 30.1 Yes No
2 empty 1.83 62.9 36.9 No No
3 empty 2.05 62.9 26.7 No No
4 empty 1.59 76.4 14.3 No No
5 empty 2.21 75.1 25 No No
6 empty .66 66.8 18.6 No No
7 empty 2.51 58.2 16.9 No No
8 empty 1.96 65.8 10.7 No No
9 empty 2.6 72.3 11.4 No No
10 empty .45 59.9 7.7 No No
3TLV_E Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 69.8 35.2 Yes Yes
2 empty 2.37 65.6 33.1 No No
3 empty 2.22 63.8 20.8 No No
4 empty 2.04 73 14.6 No No
5 empty 2.58 70.7 10.7 No No
6 empty .5 66.3 17.8 No No
7 empty 2.3 59.5 12.4 No No
8 empty 2.62 61.3 11.3 No No
9 empty 2.32 59.4 15.3 No No
10 empty 2.32 59 9.4 No No
6F16_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.19 61.8 39.5 Yes No
2 bound 2.41 66.1 33.1 No No
3 empty 1.82 70.7 17.6 No No
4 empty 2.33 66.5 20.7 No No
5 bound .7 71.5 18.2 No No
6 empty 1.95 74.8 15.6 No No
7 empty 2.31 56.1 11.8 No No
8 empty 2.53 61 10.8 No No
9 empty 2.49 64.3 12.7 No No
10 empty 1.58 59.2 12.3 No No
5HCJ_D Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 67.2 31 Yes Yes
2 empty 2.25 66.8 25.4 No No
3 empty 2.1 64.9 25.3 No No
4 empty .72 72.6 19.5 No No
5 empty 2.34 68.6 15 No No
6 empty 2.42 60.2 18.7 No No
7 empty .4 65.8 14.7 No No
8 empty 2.66 69.4 10.6 No No
9 empty 2.57 58.7 12.7 No No
10 empty 2.33 63.6 11.4 No No
5IUX_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 63.1 36.7 Yes No
2 bound 2.38 65.6 28.4 No No
3 bound 2.17 62.9 26.7 No No
4 empty 1.9 76.6 12 No No
5 empty 2.21 61.7 24.4 No No
6 empty 2.33 69.9 12.8 No No
7 empty 2.25 60 11.1 No No
8 bound .45 75.4 11.7 No No
9 empty 2.61 61.6 18.9 No No
10 bound 2.02 56.1 13.1 No No
6F0Z_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.4 62.6 29.9 Yes No
2 bound 1.99 63 29.7 No No
3 empty 2.06 64.1 25 No No
4 empty 1.82 71 16.4 No No
5 empty 2.22 67.6 20.4 No No
6 bound 1.02 70 18 No No
7 empty 2.01 73.4 13.4 No No
8 empty 1.79 58.1 13.6 No No
9 empty 1.96 54 14.4 No No
10 empty 2.2 60.1 11.5 No No
5OSC_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 64.1 30.6 Yes No
2 empty 2.11 68.8 23.6 No No
3 empty 2.13 73.4 13.5 No No
4 empty 2.23 62.3 17.5 No No
5 empty 2.1 57.3 19.6 No No
6 empty 2.37 74.4 18.3 No No
7 empty 2.59 59.3 12.1 No No
8 empty 2.16 62.6 11.3 No No
9 empty 2.69 72 10.4 No No
10 empty 1.14 64.9 8.6 No No
6HYV_E Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 No No
2 No No
3 No No
4 No No
5 No No
6 No No
7 No No
8 No No
9 No No
10 No No
4QH4_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.73 62.5 37.7 Yes No
2 empty 2.4 65 33.8 No No
3 empty 1.74 76 14.2 No No
4 empty 2.15 63.1 25 No No
5 empty 2.26 69.9 16.4 No No
6 empty 2.5 60.6 16.9 No No
7 empty 1.67 54.6 15.5 No No
8 empty 2.96 60.2 11 No No
9 empty 2.09 78.2 11.6 No No
10 empty 2.19 57.9 12.8 No No
2XQ3_E Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 68.2 23.9 No No
2 empty 2.16 61.5 27.9 No No
3 empty 2.2 67.2 25.4 No No
4 empty 1.79 75.6 13.5 No No
5 empty 2.28 70.4 18 No No
6 empty 2.22 52.6 15.1 No No
7 empty .83 67.3 11.6 No No
8 empty 2.45 63.4 12.3 No No
9 empty 2.49 58.7 14 No No
10 empty 2.17 73.7 11.4 No No
5MZQ_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 65.8 35.5 Yes No
2 bound 2.27 69.3 23.3 No No
3 empty 1.76 71 16.2 No No
4 empty 2.43 68.9 20.6 No No
5 empty .49 67.2 17.4 No No
6 empty 2.41 59.8 14.5 No No
7 empty 2.8 70.5 10 No No
8 empty 2.27 64.7 19 No No
9 empty 2.58 60.3 18 No No
10 empty 2.32 54 13 No No
3UU6_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 64.8 34.7 Yes No
2 empty 2.44 65.8 31.2 No No
3 empty 2.15 64.7 24.5 No No
4 empty 2.21 62.8 21.6 No No
5 empty 2.44 73.4 17.5 No No
6 bound .77 68.3 18.8 No No
7 empty 2.68 68.1 9.6 No No
8 empty 2.3 56.1 12.6 No No
9 empty 2.17 56.5 14.5 No No
10 empty 2.37 61.6 11.4 No No
3UU5_C Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 66.9 21.1 No No
2 empty 2.06 62.8 24.4 No No
3 bound 2.11 61.3 26.9 No No
4 empty 1.88 72.6 11.5 No No
5 empty 2.26 66.9 17.5 No No
6 empty 2.33 61.3 15.6 No No
7 bound .74 67.4 14.8 No No
8 empty 2.28 72 14.3 No No
9 empty .45 67.9 12.6 No No
10 empty 2.66 68.8 10.9 No No
4IL4_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.76 65.1 38 Yes No
2 bound 2.19 65.6 25.2 No No
3 empty 2.09 64 26.1 No No
4 empty 1.88 74.7 12.3 No No
5 empty 2.17 70.7 17.8 No No
6 empty 2.23 69 20.4 No No
7 empty 2.41 62.1 14.5 No No
8 empty 2.63 64.9 11.9 No No
9 empty 2.71 60.5 13.5 No No
10 empty 2.38 50.6 11.9 No No
5HEG_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 68.5 33.1 Yes Yes
2 empty 2.37 66.9 28.2 No No
3 empty 2.23 63.5 28.3 No No
4 empty 1.25 66.2 27 No No
5 empty 2.49 69.5 20.1 No No
6 empty 2.26 46.5 15 No No
7 empty 2.38 60.5 16.5 No No
8 empty 1.95 77.1 12.1 No No
9 empty .49 73 8.3 No No
10 empty 2.74 70.7 8.9 No No
6HYZ_B Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.27 67.8 20.2 No No
2 empty 2.07 60.3 22 No No
3 bound 2.28 60.8 27 No No
4 empty 1.65 67.8 18.9 No No
5 empty 2.19 71.6 13.1 No No
6 empty 1.72 63.9 15.9 No No
7 bound .82 67.9 13.1 No No
8 empty 2.69 64.1 10.7 No No
9 empty 2.33 59.5 14.9 No No
10 empty 2.66 68.6 12 No No
5MZQ_B Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 68.4 36.4 Yes Yes
2 bound 2.36 67.5 29.4 No No
3 empty 2.08 67.2 26.7 No No
4 empty 1.79 69.9 16.2 No No
5 empty 2.02 76.4 10.9 No No
6 empty 2.71 67.7 12 No No
7 empty 2.14 77 14.4 No No
8 empty 2.41 65.1 7.7 No No
9 bound 2.05 58.8 13.3 No No
10 empty 1.8 50.9 13.3 No No
2XQ9_E Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 66.2 20.2 No No
2 empty 2.33 66.8 23.7 No No
3 empty 2 61.4 27.5 No No
4 empty 2.34 71.8 21.1 No No
5 empty 1.68 75 13.6 No No
6 empty .8 69.3 16.8 No No
7 empty 2.12 44.5 13.9 No No
8 empty 2.48 59.1 14.9 No No
9 empty 2.49 68.4 11.8 No No
10 empty 2.23 59.4 14.5 No No
6F0U_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 62.5 34.5 Yes No
2 empty 2.13 65.5 27 No No
3 bound 2.24 67.5 22.7 No No
4 empty 1.8 71.2 15.7 No No
5 empty 2.24 67 19.2 No No
6 empty 2.25 59.4 15.2 No No
7 empty 1.91 66.3 12.8 No No
8 empty 2.04 70 17.3 No No
9 bound 1.97 59.6 11.2 No No
10 empty 2.7 68.7 8.2 No No
5NKJ_D Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 68.1 33.8 Yes Yes
2 empty 2.37 65.1 27.6 No No
3 empty 2.32 64.5 28.2 No No
4 empty 1.97 68.8 18.1 No No
5 empty 2.39 61.1 28.2 No No
6 empty 2.38 56.2 19.2 No No
7 empty .58 67.6 11.6 No No
8 empty 2.78 68.8 10.7 No No
9 empty 1.98 64.1 12.1 No No
10 empty 1.83 61.7 15 No No
6HJB_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.22 63.4 41.9 Yes No
2 empty 2.31 67.7 28.7 No No
3 empty 1.8 70 19.5 No No
4 bound 1.05 66.1 15 No No
5 empty 2.73 63.2 13 No No
6 empty 1.96 70.7 13.6 No No
7 empty 2.78 69.6 10.9 No No
8 bound 1.76 61.2 12.1 No No
9 empty 1.86 54.7 14.5 No No
10 empty 2.28 61.7 7.7 No No
6F15_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.38 65.8 29.7 Yes No
2 bound 1.94 64.1 40.4 No No
3 empty 2.14 61.7 25.5 No No
4 empty 1.79 71.7 16 No No
5 empty 2.24 67.4 21.5 No No
6 bound .66 62.3 17.7 No No
7 empty 2.26 71.1 21.5 No No
8 bound 1.94 59 15.6 No No
9 empty 2.17 53.7 12.2 No No
10 empty 1.83 57.2 13.8 No No
6F12_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.46 63.3 33.9 Yes No
2 empty 1.85 67.9 29.6 No No
3 empty 2.06 63.5 26.6 No No
4 empty 1.83 72.8 16.9 No No
5 empty 2.19 66.3 20.3 No No
6 bound 1.06 62.1 18.6 No No
7 empty 1.71 55.1 12.9 No No
8 empty 2.59 65.7 10.6 No No
9 empty 2.17 61.7 14.4 No No
10 empty 2.25 56.2 11.4 No No
3EAM_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.17 63.4 38.4 Yes No
2 empty 2.38 67.6 32.6 No No
3 empty 1.76 73.2 15.8 No No
4 empty 2.29 70 16.9 No No
5 bound .44 68 18.8 No No
6 empty 2.72 69 10.5 No No
7 empty 2.18 68.5 17.3 No No
8 empty 2.65 62.6 13.4 No No
9 empty 2.36 58.1 11.9 No No
10 empty 1.8 54.5 15.3 No No
4QH1_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 62.9 40.2 Yes No
2 bound 2.45 66.9 29.3 No No
3 empty 1.77 75.9 14.5 No No
4 empty 2.43 66.4 20.2 No No
5 empty 2.15 75.4 14.7 No No
6 empty 2.55 62.7 12.2 No No
7 empty 2 63.3 12.4 No No
8 empty 2.21 60.6 11.9 No No
9 empty 2.27 53.5 12.2 No No
10 empty 2.39 59 12.1 No No
4HFB_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.16 64.8 28.4 Yes No
2 bound 2.1 60.2 26.2 No No
3 empty 2.04 63.2 26.9 No No
4 empty 1.81 72.1 15.6 No No
5 bound .73 74.1 15.6 No No
6 empty 2.4 65.2 19.5 No No
7 empty .49 69.7 15.1 No No
8 empty 2.57 70.9 9.2 No No
9 empty 2.4 62.7 13.8 No No
10 empty 2.08 73.4 13.7 No No
6HY9_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.28 66.4 35.4 Yes No
2 empty 2.42 63.2 35.7 No No
3 empty 1.69 60 28.3 No No
4 empty 1.82 69.7 17.2 No No
5 empty .67 69.1 14.3 No No
6 empty 2.33 69.4 9.8 No No
7 empty 2.07 62.5 16.5 No No
8 empty 2.4 64.7 19.5 No No
9 empty 2.65 70.6 10 No No
10 empty 2.2 71.6 12.6 No No
3UU3_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.99 65.4 38 Yes No
2 empty 2.53 65.3 30 No No
3 empty 2.4 64.3 32.1 No No
4 empty .88 67.6 23.3 No No
5 empty 2.16 74.1 26.4 No No
6 empty 2.14 65.2 16 No No
7 empty 2.33 52.1 15 No No
8 empty 2.58 58.2 11.7 No No
9 empty 2.89 74.8 11.9 No No
10 empty 2.15 62.2 12.2 No No
3LSV_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.77 64.9 39.1 Yes No
2 empty 2.36 67.9 34.5 No No
3 empty 2.21 64.8 25.5 No No
4 empty 1.75 70 16.9 No No
5 empty 2.22 73.6 11.6 No No
6 empty 2.21 71 17.1 No No
7 empty 2.62 69.5 9.4 No No
8 empty 2.37 65 12.4 No No
9 empty 2.28 57.6 11.3 No No
10 empty 1.86 52.9 14.8 No No
3P4W_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 64.6 37.2 Yes No
2 empty 2.38 66.4 32.9 No No
3 empty 2.05 65.1 25.2 No No
4 empty 1.83 73.8 17.6 No No
5 empty 2.39 70.8 14.8 No No
6 empty 1.95 62.7 20.6 No No
7 empty 2.52 67.8 10.1 No No
8 empty 2.33 59.6 11.6 No No
9 empty 1.9 53.7 13.8 No No
10 empty 2.19 53.7 10.8 No No
3UU4_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 62.2 35.3 Yes No
2 empty 1.83 65.5 43.7 No No
3 empty 2.05 67.1 25.9 No No
4 empty 2.34 67.8 31.3 No No
5 empty 1.76 72.8 13.7 No No
6 empty .66 67.5 15.8 No No
7 empty 2.61 61.8 12.8 No No
8 empty 2.35 56.4 11.3 No No
9 empty 2.58 58.8 11.9 No No
10 empty 2.93 63.9 11.9 No No
6EMX_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.47 64.2 32.8 Yes No
2 empty 1.94 62.9 35.3 No No
3 empty 1.92 62.6 25.1 No No
4 empty 1.8 71.8 17.3 No No
5 bound 1.4 72.2 21.2 No No
6 empty 2.06 74.6 10.8 No No
7 empty 2.21 66.8 16.5 No No
8 empty 2.69 72.2 10.8 No No
9 empty 2.53 64.9 18 No No
10 empty 2.25 60.2 12.1 No No
4QH4_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.65 65.9 39.4 Yes No
2 bound 2.44 66.6 29.6 No No
3 empty 1.79 73.7 15 No No
4 empty 2.37 67.6 18.5 No No
5 empty 2.06 61.5 25.7 No No
6 empty 2.14 60 18.3 No No
7 empty 2.54 63.5 17.4 No No
8 empty 2.35 57 11.7 No No
9 empty 2.29 64.7 9.8 No No
10 empty 2.07 77.2 7.7 No No
6F13_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.14 62.4 38.2 Yes No
2 bound 2.4 65.7 30.2 No No
3 empty 1.84 68.6 16.7 No No
4 empty 1.59 64.4 17.5 No No
5 empty 1.93 73.5 13.1 No No
6 empty 2.22 69.1 13.4 No No
7 empty 2.62 61.1 14.4 No No
8 empty 2.61 71.6 10.5 No No
9 bound 1.9 59.6 13.9 No No
10 empty 2.36 66.3 7.3 No No
4NPQ_Q Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 65.2 35.6 Yes No
2 empty 2.11 66.3 29.4 No No
3 empty 2.07 67.3 23.3 No No
4 empty 1.78 77.8 17.6 No No
5 empty 1.65 64.5 17.3 No No
6 empty 2 63.9 14.7 No No
7 empty .97 70.7 14.8 No No
8 empty .83 65 30.8 No No
9 empty 2.68 65.7 15.9 No No
10 empty 1.88 64.3 13.6 No No
4F8H_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 62.6 36.5 Yes No
2 empty 2.2 69.2 19.6 No No
3 bound 2.24 62 26.7 No No
4 empty 1.94 73.7 15.1 No No
5 empty 2.41 69.4 19.5 No No
6 empty 2.37 59.8 15.8 No No
7 empty 2.6 69.2 8.8 No No
8 empty 2.45 61.9 17.6 No No
9 empty 2.47 66.2 11.7 No No
10 empty 2.05 56.7 15.5 No No
6F11_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 64.1 44.4 Yes No
2 bound 2.42 65.8 30 No No
3 empty 1.78 68.6 19 No No
4 empty 2.23 68.2 18.9 No No
5 empty 1.03 67.9 11.4 No No
6 empty 2.25 71.9 18.4 No No
7 empty 1.7 57.5 10.7 No No
8 empty 2.35 54.6 12.8 No No
9 empty 2.15 61 12.4 No No
10 empty 2.03 56.8 11.7 No No
6HJ3_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 62.8 39.9 Yes No
2 empty 2.15 70.4 21.4 No No
3 empty 2.13 63 25.9 No No
4 empty 1.76 73.2 16.6 No No
5 empty 2.46 68 14 No No
6 bound 1.04 60.9 15.7 No No
7 empty 2.39 61.4 13.3 No No
8 bound 1.85 60.3 12.4 No No
9 empty 2.72 67.6 10.6 No No
10 empty 2.05 68 17.6 No No
6F0N_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 64.3 49.9 Yes No
2 bound 2.35 64.9 29.4 No No
3 empty 1.8 71.1 15.9 No No
4 empty 2.22 68 20.5 No No
5 empty 2.14 74.1 15.3 No No
6 empty 2.62 64.9 9.4 No No
7 bound 1.79 57.4 15.1 No No
8 empty 2.2 56 11.8 No No
9 empty 1.67 60.1 12.2 No No
10 empty 2.39 65.6 10.3 No No
6F0R_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.8 64.4 43.5 Yes No
2 bound 2.31 67.6 20.4 No No
3 empty 2.16 62.5 26.8 No No
4 empty 1.75 71.9 19.4 No No
5 empty 2.34 68.3 19.6 No No
6 empty 2.54 65.8 15.8 No No
7 bound .75 65.3 15 No No
8 bound 1.91 56.1 15.8 No No
9 empty 2.17 54.5 11.8 No No
10 empty 2.05 70.6 11.5 No No
4ILC_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 62.2 32.3 Yes No
2 bound 2.21 66.2 24.5 No No
3 empty 1.84 72.3 16.5 No No
4 empty 2.29 75 16.1 No No
5 empty 2.06 64.8 21.8 No No
6 bound .73 66.6 12.6 No No
7 empty .34 70.1 9.2 No No
8 empty 2.46 58.5 14.6 No No
9 empty 2.52 62.9 12.2 No No
10 bound 2.01 55.7 14.7 No No
5MVN_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.76 65.9 38 Yes No
2 bound 2.29 65.7 27.1 No No
3 empty 1.96 62.9 25.3 No No
4 empty 1.77 73.9 17 No No
5 empty 2.27 70.4 19.6 No No
6 empty 2.34 58.4 14.5 No No
7 empty 2.56 69.6 9.8 No No
8 empty 2.38 59.7 18.3 No No
9 empty 2.42 64.4 11 No No
10 empty 1.82 55.2 13.8 No No
4QH4_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.46 66.5 32.7 Yes No
2 empty 1.78 62.2 31.7 No No
3 empty 2.16 64 25.9 No No
4 empty 2.33 70.3 23 No No
5 empty 1.8 74.3 13.1 No No
6 empty 2.49 62.5 17.2 No No
7 empty 2.18 54.2 12.6 No No
8 empty 2.22 63.4 12.8 No No
9 empty 1.73 56.1 14.2 No No
10 empty 2.16 78.6 6.6 No No
6HPP_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 63.8 50.2 Yes No
2 bound 2.44 68.5 28.7 No No
3 empty 2.33 63.3 30.1 No No
4 empty 1.76 69.3 18.4 No No
5 empty 2.67 72.3 9.7 No No
6 empty 2.53 62 18.9 No No
7 empty 2.36 55.2 11.9 No No
8 empty 2.11 59 10.4 No No
9 empty 1.83 53.1 14.1 No No
10 empty .34 61.9 10.9 No No
6F0N_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 64.8 39.7 Yes No
2 bound 2.29 66 23.1 No No
3 empty 1.79 69.7 17 No No
4 empty 2.21 67.7 21.3 No No
5 bound .66 67.4 18.9 No No
6 empty 2.29 55.9 14.4 No No
7 empty 2.59 68 10.5 No No
8 empty 2.09 71.3 14.6 No No
9 empty 2.17 54.3 12.7 No No
10 empty 1.68 56.1 13.7 No No
6HYZ_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.22 65.3 27.8 Yes No
2 empty 2.23 64.1 24.3 No No
3 empty 2.17 62.6 22.5 No No
4 empty 1.64 71.6 17.6 No No
5 bound 1.23 66 19.9 No No
6 empty 1.46 67.5 19.3 No No
7 empty 2.16 69.3 22.6 No No
8 empty 2.69 62.1 17.2 No No
9 empty 2.46 56.8 14.8 No No
10 empty 2.64 58.2 11.7 No No
6HY9_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.42 63.3 32.1 Yes No
2 empty 2.16 64.5 29.7 No No
3 empty 1.79 73.1 13.2 No No
4 empty .69 66 17.8 No No
5 empty 2.33 68.6 23 No No
6 empty 2.28 59.8 14.8 No No
7 empty 2.66 68.4 10.9 No No
8 empty 2.07 61.1 12.6 No No
9 empty .45 63.7 10.1 No No
10 empty 2.24 57.6 14.9 No No
6HYX_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 64.1 32.9 Yes No
2 empty 2.08 65.4 26.5 No No
3 empty 2.26 62.3 25.8 No No
4 empty 1.62 66 20.3 No No
5 empty 2.16 69.5 20 No No
6 empty .71 67.1 17.9 No No
7 empty 1.43 76.5 12.6 No No
8 empty 2.26 63.1 25 No No
9 empty 2.41 60.3 12.9 No No
10 empty 2.7 72.9 8.1 No No
6HJI_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 64.8 36.4 Yes No
2 bound 2.42 63.8 33.8 No No
3 empty 2.11 63.3 26.7 No No
4 empty 1.83 71.3 16.6 No No
5 empty 2.26 70.5 22.6 No No
6 empty 2.71 67 10.9 No No
7 empty 2.38 62.2 11.9 No No
8 empty 2.48 59.6 12.3 No No
9 empty 1.84 55.6 13.8 No No
10 empty .29 65.4 10.4 No No
5MZR_D Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 66.5 37.8 Yes Yes
2 bound 2.48 64.5 29.9 No No
3 empty 2.19 60.8 26.6 No No
4 empty 1.79 70.1 16.3 No No
5 empty 2.35 70.8 15.6 No No
6 empty .38 69.1 11.9 No No
7 empty 1.92 58.4 16.5 No No
8 empty 2.56 65.6 11.6 No No
9 empty 2.11 76.2 13.8 No No
10 bound 2.04 59.5 13.7 No No
5L4E_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 69.1 32.6 Yes Yes
2 empty 1.95 67.2 37.2 No No
3 empty 2.46 62 34.8 No No
4 empty 2.05 68.8 15.8 No No
5 empty .51 67.3 20.1 No No
6 empty 2.21 61.9 11.4 No No
7 empty 2.52 59.1 14.3 No No
8 empty 2.01 60.1 13.7 No No
9 empty 2.8 71.4 10.1 No No
10 empty 2.09 59.8 10.9 No No
4ZZB_D Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 69.3 37.8 Yes Yes
2 bound 2.46 66.1 35 No No
3 empty 2.28 68.5 19.7 No No
4 empty .7 70.1 18.8 No No
5 empty .48 68.2 21.7 No No
6 empty 2.43 59 18.2 No No
7 empty 2.7 69.9 10.1 No No
8 empty 2.3 61.7 11.9 No No
9 empty 2.11 61.1 15.4 No No
10 empty 1.74 54.6 15.3 No No
6HJA_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 65.4 30.2 Yes No
2 empty 2.12 63.4 24.9 No No
3 empty 2.14 63.1 22.6 No No
4 empty 1.96 75 11.5 No No
5 bound 1.3 68.9 25 No No
6 empty 2.17 71.4 21.3 No No
7 empty .47 71.4 8.5 No No
8 empty 2.63 68.1 12.2 No No
9 empty 2.58 67.5 13.4 No No
10 empty 2.25 62.3 14.3 No No
4IL4_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.39 65.2 29.1 Yes No
2 empty 1.93 62.9 38 No No
3 empty 2.26 71.9 26.3 No No
4 empty 2.18 62.2 26.4 No No
5 empty 1.86 75.7 11.2 No No
6 empty .72 73.4 18.9 No No
7 empty 2.65 70.1 9.7 No No
8 bound 2.09 58.4 14 No No
9 empty 2.55 60.3 11.4 No No
10 empty 2.33 50.4 10.2 No No
4ILA_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.14 65.6 36.2 Yes No
2 bound 2.25 65.1 23.9 No No
3 empty 1.78 74.2 14.6 No No
4 empty 2.47 67.1 20.2 No No
5 empty 2.03 70.5 17.7 No No
6 empty 2.53 61.6 17.6 No No
7 empty 2.4 58.9 14 No No
8 empty .48 71.4 15.9 No No
9 empty 2.53 61.3 12.3 No No
10 empty 2.23 57.4 15 No No
5NJY_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 71.6 21.5 Yes No
2 empty 2.41 68 28 No No
3 empty 2.05 61.9 31.9 No No
4 empty 2.16 66 16.7 No No
5 empty 2.32 59.2 19.5 No No
6 empty 1.99 72.9 12.7 No No
7 empty .91 64.5 16.1 No No
8 empty 2.19 55.9 13.3 No No
9 empty 2.58 63.7 17.2 No No
10 empty .58 71 8.5 No No
5V6O_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 64.2 37.3 Yes No
2 empty 2.23 67.1 30.2 No No
3 empty 1.89 71.7 13.2 No No
4 empty 2.31 67.6 26.9 No No
5 empty .7 67.8 14.2 No No
6 empty 2.46 58.8 15.8 No No
7 empty 2.9 76.2 9.6 No No
8 empty 2.45 66.8 8.7 No No
9 empty 2.37 76.9 7 No No
10 empty 1.6 52.7 11.3 No No
4LMK_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 64.4 40.5 Yes No
2 empty 2.39 65.7 29.9 No No
3 empty 2.27 67.7 25.3 No No
4 empty 1.07 66.5 17.8 No No
5 empty 2.5 61 19 No No
6 empty 2.06 76.7 9.7 No No
7 empty 2.5 48.2 12.6 No No
8 empty .23 77 5.7 No No
9 empty 2.66 75.8 8.3 No No
10 empty 2.48 54.3 9.6 No No
3TLV_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 68.5 37.7 Yes Yes
2 empty 2.48 64.9 33.3 No No
3 empty 1.98 74.6 13.4 No No
4 empty .55 70.7 9.7 No No
5 empty 2.13 63.5 13.2 No No
6 empty 2.75 65.4 11.9 No No
7 empty 2.51 56.6 11.3 No No
8 empty 2.45 60.8 10.3 No No
9 empty 2.12 68.1 9.9 No No
10 empty 3.04 62.6 10.9 No No
5HCM_E Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 66.4 35.9 Yes Yes
2 empty 2.49 65.4 34.8 No No
3 empty 2.15 66.1 26.1 No No
4 empty 2.25 62.5 21.5 No No
5 empty 2 69.8 14.7 No No
6 empty .47 67.6 18.9 No No
7 empty 2.76 77.1 9.6 No No
8 empty 2.23 57.5 11.4 No No
9 empty 2.21 63.1 9.8 No No
10 empty 2.22 56.6 12.7 No No
5L47_B Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 66.4 40.4 Yes Yes
2 bound 2.29 67.4 29.5 No No
3 empty 2.39 71.5 14.9 No No
4 empty 2.34 57.7 14.7 No No
5 empty 2.59 59.1 12.2 No No
6 empty 2.23 80.6 11.6 No No
7 empty 2.19 62.4 10.5 No No
8 empty 2.48 62.1 8.5 No No
9 empty .4 63 12.1 No No
10 empty 2.65 58.4 9.3 No No
6HJZ_F Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.16 63.8 42 Yes No
2 bound 2.17 68.4 19.9 No No
3 empty 1.83 73.7 16.7 No No
4 empty 2.41 68.5 24.7 No No
5 bound .71 64.4 16.9 No No
6 empty 2.36 57.6 14.4 No No
7 empty 2.69 61.4 14 No No
8 empty 2.05 72.6 15.8 No No
9 empty 2.45 58.4 20.1 No No
10 empty 2.74 75.6 8.6 No No
6HYW_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.37 64.4 31.2 Yes No
2 bound 1.91 62.3 38.7 No No
3 empty 2.13 63.1 26.8 No No
4 empty 1.79 76.8 11.3 No No
5 empty 2.25 66.4 22.1 No No
6 bound .7 61.3 18.3 No No
7 empty 2.06 72.7 18.5 No No
8 empty 1.79 55.2 13.8 No No
9 empty 2.52 64.6 10.2 No No
10 empty 2.24 54.8 11.7 No No
3TLT_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 67.9 27.3 Yes Yes
2 empty 2.17 68.2 24.1 No No
3 empty 2.17 64.3 26 No No
4 empty 2.14 70 22.3 No No
5 empty 1.66 70.3 16.7 No No
6 empty .9 72.3 15.8 No No
7 empty 2.63 60.5 14.9 No No
8 empty 2.35 59.2 15.4 No No
9 empty 2.73 69.6 9.6 No No
10 empty .38 70.3 10 No No
6HJA_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.24 63 45.9 Yes No
2 empty 2.34 67 36.1 No No
3 empty 1.78 70 18.5 No No
4 empty 2.24 64.5 16 No No
5 bound .75 64.5 12.9 No No
6 empty 2.38 68.4 20.4 No No
7 empty 2.62 72.7 8.8 No No
8 empty 2.54 69.6 8.6 No No
9 empty 2.76 56.5 12.4 No No
10 empty 2.29 56.3 11.4 No No
6F0Z_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 65.2 52.4 Yes No
2 bound 2.51 65.4 35.9 No No
3 empty 1.79 71.1 18.3 No No
4 empty 2.23 63.9 15.2 No No
5 empty 2.09 72.6 13.5 No No
6 empty 1.81 56.6 13.2 No No
7 empty 2.68 68.8 13.1 No No
8 empty 2.22 55.4 12.2 No No
9 empty 2.5 66.1 7 No No
10 empty 2.77 59.2 11.4 No No
6F15_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.42 65.7 29.8 Yes No
2 empty 2.13 62.6 26.6 No No
3 bound 2.06 58.8 30.8 No No
4 empty 1.8 69.2 18.8 No No
5 empty 2.36 73.1 15.6 No No
6 bound .66 67.9 17 No No
7 empty .47 67 19.4 No No
8 empty 2.2 56.1 11.6 No No
9 empty 1.77 63.3 8.3 No No
10 bound 1.98 60.1 14.1 No No
6F13_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 65 38.3 Yes No
2 empty 1.79 68.7 17.1 No No
3 bound 1.31 60.9 20 No No
4 bound 2.05 66.1 20.1 No No
5 empty 2.23 68 15.8 No No
6 empty 2.28 68.6 19.3 No No
7 empty 2.62 57.3 16.5 No No
8 empty 2.36 58.8 14.4 No No
9 empty 2.67 61.8 12.8 No No
10 bound 2.1 56.2 14.2 No No
4HFD_E Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.75 66.5 36.8 Yes Yes
2 bound 2.29 64.5 25.5 No No
3 empty 2.21 62.3 26.8 No No
4 empty 1.86 72.8 16.3 No No
5 empty 2.28 61.5 26.7 No No
6 empty 2.44 65.6 15 No No
7 empty 2.41 62.4 13.7 No No
8 empty 2.71 69.2 9.7 No No
9 empty 2.67 61.2 12.9 No No
10 empty 2.43 65 10.4 No No
3UUB_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 61.7 40.9 Yes No
2 empty 2.45 64 32.4 No No
3 empty 1.86 74.6 14.1 No No
4 empty 2.26 68.5 15.5 No No
5 bound 1.45 65.6 19.2 No No
6 empty 2.21 70.7 17.9 No No
7 empty 2.71 71.6 12.7 No No
8 empty 2.62 65.3 16.9 No No
9 empty 2.27 55.5 12.4 No No
10 empty 2.81 60 10.2 No No
4LML_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 68.4 26.9 Yes No
2 empty 2 63.9 30.7 No No
3 empty 2.21 70.7 19.1 No No
4 empty 2.23 67.9 23.6 No No
5 empty 1.66 76.1 15.2 No No
6 empty 1.15 66.3 24 No No
7 empty 2.41 62.9 10.3 No No
8 empty 2.46 60.8 14.7 No No
9 empty 2.71 67.3 11.7 No No
10 empty 2.47 56.9 12.1 No No
3UU8_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.43 65.2 32.8 Yes No
2 bound 1.92 63.6 31.8 No No
3 empty 2.06 66.8 26.5 No No
4 empty 1.7 66.9 17.8 No No
5 bound .68 69.2 14.2 No No
6 empty 1.87 77.6 11 No No
7 empty 2.29 73.8 14.1 No No
8 empty 2.69 69.4 12.3 No No
9 empty 2.44 55.1 11 No No
10 empty .38 62.5 13.2 No No
5MVM_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.04 65.7 40.3 Yes No
2 bound 2.41 65.4 31.3 No No
3 bound 1.71 70.9 18.8 No No
4 empty 2.38 64.5 14.2 No No
5 empty 2.26 70.9 19 No No
6 empty 2.57 65.2 10.5 No No
7 empty 2.26 61 10.8 No No
8 empty 1.92 79.4 9.5 No No
9 empty 2.43 57.7 12.1 No No
10 empty 2.38 64.5 8.1 No No
6F10_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 63.5 40 Yes No
2 bound 2.41 63.5 35 No No
3 empty 1.92 74.8 12.3 No No
4 empty 2.23 64.5 24.3 No No
5 bound .72 64.4 14.5 No No
6 empty 1.96 69.6 17.9 No No
7 empty 1.73 61.7 13.1 No No
8 empty 2.62 61.1 12.2 No No
9 empty 2.31 59.4 11.8 No No
10 empty 2.52 63.3 13 No No
3EHZ_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 63.1 36.2 Yes No
2 empty 2.37 66 30.1 No No
3 empty 2.25 71.2 24.5 No No
4 empty 1.77 76.3 13.3 No No
5 empty .86 72.4 12.6 No No
6 empty 2.23 41.4 14.6 No No
7 empty 2.68 66.7 11.4 No No
8 empty 2.6 63.2 10.6 No No
9 empty 2.27 68 12.2 No No
10 empty 2.25 61.2 16.7 No No
5V6N_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 64.9 39.4 Yes No
2 empty 2.27 68.6 19.6 No No
3 empty 2.08 65.9 26.3 No No
4 empty .88 67.1 20 No No
5 empty 1.86 70.3 16.7 No No
6 empty 2.33 56.5 15 No No
7 empty 2.37 59.5 16.8 No No
8 empty 2.12 56.3 20.3 No No
9 empty 2.18 52.4 13.2 No No
10 empty 2.07 62.6 14.1 No No
5OSA_D Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 69.5 22.4 No No
2 bound 2.21 65.1 19.5 No No
3 empty 2.31 72.2 16.7 No No
4 empty 2.28 59.1 13.8 No No
5 empty 2.42 58.6 16.3 No No
6 empty 2.23 60.4 17.6 No No
7 empty 2.07 78.3 16.1 No No
8 empty 2.15 60.5 12.8 No No
9 empty 2.45 62.1 18.8 No No
10 empty 2.65 72.4 10.1 No No
4QH5_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.53 67.3 34.3 Yes No
2 empty 2.11 65.8 25 No No
3 empty 1.83 70.4 17.5 No No
4 empty 2.32 63.8 26.4 No No
5 empty 2.45 70.5 14.5 No No
6 empty 1.58 65.2 23.5 No No
7 empty 2.35 67.6 19.4 No No
8 empty 1.09 65.8 14.5 No No
9 empty 1.73 54.7 14.2 No No
10 empty 2.38 59.3 10.7 No No
3TLS_B Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 66.5 32.7 Yes Yes
2 empty 2.42 64.4 34.8 No No
3 empty 2.03 65.1 25.8 No No
4 empty 2.36 71.1 21.2 No No
5 empty .49 68.7 15.5 No No
6 empty 2.81 73.4 10.2 No No
7 empty 2.55 64.1 14.1 No No
8 empty 2.07 67.9 10.7 No No
9 empty 2.26 59.9 14 No No
10 empty 2.41 62.6 9.8 No No
4NPQ_P Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 69 36.3 Yes Yes
2 empty 2.09 70.3 25.6 No No
3 empty 2.11 63.6 27.2 No No
4 empty .91 74 15.9 No No
5 empty 1.69 71.6 9.6 No No
6 empty 1.91 65 16.9 No No
7 empty 2.02 60.8 16.2 No No
8 empty 1.66 81.2 11.8 No No
9 empty .25 56.7 13.3 No No
10 empty .88 70.5 9.1 No No
2XQA_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 65.3 36.8 Yes No
2 empty 2.1 68.5 20.7 No No
3 empty 1.8 75.1 14.7 No No
4 empty 2.01 58.1 17.8 No No
5 empty 2.33 68.4 17.8 No No
6 empty .79 67.1 16.8 No No
7 empty 2.46 64.1 13.8 No No
8 empty 2.42 57.6 15.1 No No
9 empty 2.59 65.1 9 No No
10 empty 1.93 59.1 14.7 No No
4HFB_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.25 63.1 35.8 Yes No
2 bound 2.22 68.9 18.9 No No
3 empty 1.6 69.6 18.1 No No
4 bound .69 72.6 19.1 No No
5 empty 2.39 71.5 20.6 No No
6 empty 2.28 67.1 19 No No
7 empty 2.42 60.2 13.7 No No
8 empty 2.67 69.1 10.4 No No
9 bound 2.01 57.4 14.5 No No
10 empty 2.53 62.3 12.1 No No
3TLV_B Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 66.8 33.4 Yes Yes
2 empty 2.18 68.5 22.3 No No
3 empty 1.27 66.2 20.8 No No
4 empty 2.33 71.7 17.9 No No
5 empty .88 66.2 19.7 No No
6 empty 2.37 56.6 14.9 No No
7 empty 2.56 61.8 11.8 No No
8 empty 2.14 61 11.4 No No
9 empty 2.45 58.7 17.7 No No
10 empty 2.59 56 10 No No
3UU5_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.41 63.8 34.8 Yes No
2 bound 1.91 62.6 38.1 No No
3 empty 2.12 63.9 26.9 No No
4 empty 1.75 69.9 20 No No
5 bound .74 63.1 20.3 No No
6 empty 2.27 74.5 14.3 No No
7 empty 2.72 72.5 10.8 No No
8 empty 2.25 58.3 10.7 No No
9 empty 1.95 63.2 13.4 No No
10 empty 2.38 59 11.4 No No
4HFI_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.14 63.7 36.6 Yes No
2 bound 2.34 67.2 23.6 No No
3 empty 1.81 70.4 16.9 No No
4 empty 2.31 69.4 21.8 No No
5 empty 2.26 65.2 15.8 No No
6 empty 2.49 59.6 14.4 No No
7 empty .48 68.3 18.1 No No
8 empty 2.61 65.6 11.9 No No
9 bound 2.01 60.1 14.9 No No
10 empty 2.32 51.5 12.6 No No
6F0V_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.34 65.1 26.1 Yes No
2 empty 1.93 61.3 40 No No
3 empty 1.79 73.5 17.8 No No
4 empty 2 58.8 24.7 No No
5 empty 2.3 67.8 19.5 No No
6 empty .78 66.7 16.8 No No
7 empty 1.91 61.2 14.6 No No
8 empty 1.96 76.9 12.5 No No
9 empty 1.7 54.2 15.1 No No
10 empty 2.55 66.4 9.9 No No
2XQ5_E Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 66.6 22.4 No No
2 empty 2.03 62.5 30.1 No No
3 empty 2.15 66.1 24.6 No No
4 empty 2.35 71.4 21.9 No No
5 empty 1.79 75.7 13.4 No No
6 empty .83 67.8 14.3 No No
7 empty 2.44 61.6 12 No No
8 empty 2.44 56.7 14.4 No No
9 empty 2.38 46.7 13.8 No No
10 empty 2.62 66.5 10.2 No No
5MUR_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 65.6 39.2 Yes No
2 bound 2.41 64.3 35 No No
3 empty 1.84 75.3 11.7 No No
4 empty 2.36 69.9 22.6 No No
5 empty .49 70.5 15.2 No No
6 empty 2.62 69.7 10.5 No No
7 empty 2.33 59.7 10.9 No No
8 empty 2.51 60.6 13.4 No No
9 empty 2.43 54.1 11.1 No No
10 empty .31 60.3 7.3 No No
4ILB_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 62.6 32.1 Yes No
2 bound 2.29 64.4 27.5 No No
3 empty 1.92 74.8 11.4 No No
4 bound 1.39 69.9 24.2 No No
5 empty 2.4 72.2 21.9 No No
6 empty 2.18 74.8 16.7 No No
7 empty 2.42 58.2 14.7 No No
8 empty 2.54 65.8 12.6 No No
9 empty .47 69.4 10 No No
10 empty 2.42 62.7 13.4 No No
4HFH_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 65.6 42.3 Yes No
2 bound 2.45 68.4 29.9 No No
3 empty 1.79 68.7 16.7 No No
4 bound .72 77.7 16.3 No No
5 empty 2.39 71.5 12.9 No No
6 empty 2.09 73.5 15.8 No No
7 empty 2.68 67.3 11 No No
8 bound 1.97 60.9 12.9 No No
9 empty 2.44 57.5 12.1 No No
10 empty 2.3 67 7.4 No No
3IGQ_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.39 65.6 30.7 Yes No
2 empty 1.87 63.4 23.3 No No
3 empty 2.22 67.4 22 No No
4 empty 2.73 57.1 21.4 No No
5 empty 1.69 78.9 12 No No
6 empty 2.21 61.9 12.8 No No
7 empty 2.25 60.9 13.4 No No
8 empty 2.98 69.7 10.8 No No
9 empty 2.53 55.8 8.5 No No
10 empty 2.04 61 7.9 No No
3P50_B Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 66.6 34.5 Yes Yes
2 empty 2.43 65.3 34.1 No No
3 empty 2.12 66.7 24.9 No No
4 empty 1.78 68.7 16.4 No No
5 empty 2.42 69.9 16.1 No No
6 empty 2.1 69.4 15.1 No No
7 empty 2.69 72.5 10 No No
8 empty 1.72 55 13.9 No No
9 empty 2.45 64.5 10 No No
10 empty 2.38 60.6 10.5 No No
3LSV_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.39 66.1 34.2 Yes No
2 empty 1.85 63.5 32.6 No No
3 empty 2.19 66.6 24.8 No No
4 empty 1.79 70 20.5 No No
5 empty 2.3 72.6 16.1 No No
6 empty 1.08 66 13.9 No No
7 empty 2.76 66.9 11.5 No No
8 empty 2.19 70.9 15.6 No No
9 empty 2.25 63.2 9.3 No No
10 empty 2.34 58.1 10.1 No No
4NPQ_L Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 67.7 36.1 Yes Yes
2 empty 2.24 67.8 27.7 No No
3 empty 1.36 69.1 29.7 No No
4 empty 2.02 61.9 20.2 No No
5 empty 1.8 70.6 15.3 No No
6 empty .64 73 17.3 No No
7 empty 2.05 67.6 17.5 No No
8 empty 1.8 74.6 13.4 No No
9 empty 2.16 62.5 13.8 No No
10 empty .89 62.2 8.7 No No
5L4H_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 69.3 37.7 Yes Yes
2 empty 2.46 63.3 33 No No
3 empty 2.28 64.8 23.1 No No
4 empty 2.25 63 20.5 No No
5 empty .39 71.6 15.5 No No
6 empty 2.67 67.8 9.8 No No
7 empty 2.33 56.1 11.8 No No
8 empty .4 65.4 7.5 No No
9 empty 2.41 67.4 9.1 No No
10 empty .67 70.2 7.7 No No
4HFH_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.46 63.5 35.8 Yes No
2 bound 1.9 67.1 35.7 No No
3 bound 2.06 66.2 26.7 No No
4 empty 1.87 69.2 17.5 No No
5 empty 2.26 72.9 15.4 No No
6 empty 2.23 71.8 16 No No
7 empty .47 69.5 17.2 No No
8 empty 2.54 62.7 12.5 No No
9 empty 2.27 62.1 11.1 No No
10 empty 1.8 53.6 13.7 No No
5OSB_E Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 68.2 23.3 No No
2 empty 2.03 66.3 20.5 No No
3 empty 2.18 67.4 17.6 No No
4 empty 2.07 59.6 21.3 No No
5 empty 2.19 60.7 12.8 No No
6 empty 2.49 59.9 16.2 No No
7 empty 2.06 70.2 17.8 No No
8 empty 2.8 74.1 9.6 No No
9 empty 2.31 58 13.3 No No
10 empty 2.5 59.2 15.6 No No
4YEU_D Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.76 67.5 21.5 No No
2 empty 1.93 60.4 22.9 No No
3 empty 2.4 63.6 28 No No
4 empty 2.05 77 16.4 No No
5 empty 2.18 63.8 18.2 No No
6 empty .8 69.2 17.5 No No
7 empty 1.81 71 11.5 No No
8 empty 1.99 61.6 18.7 No No
9 empty 2.39 69.5 18.1 No No
10 empty 2.5 63.6 15.9 No No
6I08_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.56 69.5 32.5 Yes No
2 empty 2.3 64.1 32.9 No No
3 empty 1.92 70.2 19.3 No No
4 bound 1.4 68.4 19.1 No No
5 empty 2.39 75.2 17.8 No No
6 empty .47 67.7 18.2 No No
7 empty 2.14 58.8 11.6 No No
8 empty 2.19 74.5 11.8 No No
9 empty 1.95 64.2 11.7 No No
10 empty 2.35 65.5 7.2 No No
4NPQ_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 69.1 38.2 Yes No
2 empty 2.13 67.7 29.5 No No
3 empty 1.7 67.6 11.4 No No
4 empty 1 65.2 18 No No
5 empty 1.76 71.2 17.1 No No
6 empty 2.09 59 18 No No
7 empty 1.86 67.4 15.1 No No
8 empty .21 67.2 14.5 No No
9 empty 1.65 62.9 16.2 No No
10 empty 1.9 67.5 10.4 No No
6HJZ_H Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.28 63.4 31.9 Yes No
2 bound 2.12 66.6 18.5 No No
3 empty 1.85 68.6 17.5 No No
4 bound 1.27 68.7 19.1 No No
5 empty 2.32 70 26.7 No No
6 empty 2.38 59.9 14.8 No No
7 empty 2.6 69.3 10.7 No No
8 empty 2.08 71.6 11.4 No No
9 empty 2.51 63.1 14.3 No No
10 empty 1.95 56.9 14.4 No No
5L4H_B Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 69.8 33.9 Yes Yes
2 empty 1.92 68.4 37.1 No No
3 empty 2.4 64.6 29 No No
4 empty 2.16 74.8 10.4 No No
5 empty .37 66.9 16.3 No No
6 empty 2.55 62.5 11.7 No No
7 empty 2.13 62.5 13.4 No No
8 empty 2.25 58.9 13.9 No No
9 empty 2.6 62.6 9.6 No No
10 empty 2.5 53.4 10.1 No No
4HFI_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 66.4 45.1 Yes Yes
2 bound 2.3 65.9 20.4 No No
3 empty 2.07 63.1 26.3 No No
4 empty 1.93 76.6 11.3 No No
5 empty 2.23 72 15.8 No No
6 empty 2.34 72.2 18.2 No No
7 empty 2.41 59.3 14.2 No No
8 empty 2.62 64 13 No No
9 bound 2.03 55.2 14 No No
10 empty 2.39 61.5 12.3 No No
4IRE_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 65.7 31.4 Yes No
2 empty 2.18 67.3 25.8 No No
3 bound 2.1 62.9 28.1 No No
4 empty 1.91 71.2 17.5 No No
5 empty 1.08 66.6 24.1 No No
6 empty 2.37 69.7 13.1 No No
7 bound .76 77.3 16.5 No No
8 empty 2.12 58.7 15.9 No No
9 empty 2.81 72.7 11 No No
10 bound 2.13 61 11.9 No No
4HFC_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 66.6 36.5 Yes Yes
2 empty 2.3 65.3 30.3 No No
3 empty 1.81 72 17 No No
4 empty .48 72.2 11.3 No No
5 empty 2.23 67.8 16.7 No No
6 empty 1.82 69.3 11.1 No No
7 empty 2.42 59.1 12.8 No No
8 empty 2.53 61.8 11.4 No No
9 empty 2.05 56.4 14.1 No No
10 empty 1.78 56.5 13.9 No No
5IUX_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.39 63.6 33.9 Yes No
2 bound 1.91 62.5 36.5 No No
3 empty 1.81 67.4 19.6 No No
4 bound 2.17 64.2 26.2 No No
5 empty 2.17 72 20.6 No No
6 bound .64 66.9 19.3 No No
7 empty 1.8 66.8 17.1 No No
8 empty 2.29 63.4 10.4 No No
9 empty 2.8 70.4 8.7 No No
10 empty 1.88 54 14.7 No No
3IGQ_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.37 66.8 30.8 Yes No
2 empty 2.43 56.9 20.5 No No
3 empty 2.35 67.6 13.4 No No
4 empty 2.01 76.9 10.6 No No
5 empty 2.93 69.6 9.4 No No
6 empty 1.56 50.7 11 No No
7 empty 3.03 63.1 10 No No
8 empty 2.73 50 9.5 No No
9 empty 2.21 58.1 11.5 No No
10 empty 2.33 68.6 9.9 No No
6EMX_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 67.7 36.7 Yes Yes
2 empty 2.41 63.3 35.7 No No
3 empty 1.95 63 24.3 No No
4 empty 1.77 70.9 16.9 No No
5 empty 2.39 69 19 No No
6 empty 2.66 65 12.4 No No
7 empty 2.57 63.4 13.6 No No
8 empty 2.1 66.9 17.9 No No
9 empty 2.29 62.2 11.4 No No
10 empty 1.92 54.9 13.3 No No
3EAM_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 67.1 32.9 Yes No
2 bound 1.89 62.5 39.6 No No
3 empty 2.2 65.2 26 No No
4 empty 1.75 68.8 19.2 No No
5 empty 2.3 70.1 11.6 No No
6 bound 1.03 65.4 17.9 No No
7 empty 2.12 70.7 17.2 No No
8 empty 2.66 71.6 9 No No
9 empty 2.36 66.4 9.8 No No
10 empty 1.82 50.7 14 No No
6HYV_D Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 69.2 36.6 Yes Yes
2 bound 2.44 64.8 33.1 No No
3 bound 1.84 63.4 36.6 No No
4 empty 1.87 79.4 11.5 No No
5 empty 2.29 65.9 18.6 No No
6 empty 2.08 58.8 11.3 No No
7 empty 1.65 54.4 12.3 No No
8 empty 2.26 58.5 12.7 No No
9 empty 2.65 65.2 10 No No
10 empty 2.23 61.5 12.8 No No
5MUO_D Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 68.7 32.5 Yes Yes
2 bound 2.23 66.4 27.9 No No
3 empty .77 73.5 17.6 No No
4 empty 2.22 72 16.4 No No
5 empty .37 71.2 12.8 No No
6 empty 2.31 60.4 13.4 No No
7 empty 2.49 61.9 13.2 No No
8 empty 2.85 74.4 8.8 No No
9 empty 2.18 59.6 11.7 No No
10 empty 2.26 62.5 13.9 No No
5J0Z_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.2 67.4 28.4 Yes No
2 bound 1.86 63 36.8 No No
3 bound 2.2 62.3 25.1 No No
4 empty 1.75 71.1 14.2 No No
5 bound 1 70.6 16.9 No No
6 empty 2.28 67.8 23.9 No No
7 empty 2.51 62.2 19.9 No No
8 empty 2.5 64.4 12.9 No No
9 empty 2.29 58.4 11.3 No No
10 bound 2.47 67.1 10.3 No No
6HZ0_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 64.3 38.5 Yes No
2 bound 2.23 65.5 28.3 No No
3 empty 2.18 63.1 25 No No
4 empty 1.75 68.4 15.3 No No
5 empty 2.34 69.2 14.7 No No
6 empty 2.46 54.9 15.9 No No
7 empty 2.61 62.6 18.2 No No
8 empty 2.64 70.4 10.3 No No
9 empty 2.18 70.6 9.7 No No
10 empty 2.48 56.6 12.7 No No
5HCM_D Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 67 36.4 Yes Yes
2 empty 2.43 65.3 28.8 No No
3 empty 2 66.9 23.8 No No
4 empty 2.3 71.6 23.1 No No
5 empty .39 66.1 16.2 No No
6 empty 2.6 65.8 10.7 No No
7 empty 2.04 58 13.6 No No
8 empty 2.49 61.2 12 No No
9 empty 2.33 61.2 9.7 No No
10 empty 2.82 58.7 11.7 No No
5OSB_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 66.8 29.5 Yes No
2 empty 2.11 68.3 21.6 No No
3 empty 2.1 63.8 18.9 No No
4 empty 2.27 58.8 14.8 No No
5 empty 2.18 74 17.1 No No
6 empty 2.68 69.7 9.4 No No
7 bound 2 59.5 14.9 No No
8 empty 2.23 57.5 12.8 No No
9 empty 2.52 59.5 17.8 No No
10 empty 1.22 64.3 8.7 No No
5OSA_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 66.7 24 Yes No
2 empty 2.08 69 18.6 No No
3 empty 2.34 66.8 19.3 No No
4 empty 2.3 59.2 15.9 No No
5 empty 2.53 56.6 17 No No
6 empty 2.54 58.8 15.8 No No
7 empty 2.3 67.2 20 No No
8 empty 2.14 62.7 11.1 No No
9 empty 2.72 72.4 9.5 No No
10 empty 2.31 56.2 11.7 No No
6F7A_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 65.8 38.3 Yes No
2 empty 2.17 67.3 30.9 No No
3 empty 1.98 67.4 26.4 No No
4 empty .72 73.6 17.3 No No
5 empty 1.74 75.8 12.8 No No
6 empty 2.09 69.7 22 No No
7 empty .31 63.1 18.3 No No
8 empty 1.73 77.4 10.6 No No
9 empty 2.59 63.6 14.9 No No
10 empty 2.16 61 12.9 No No
3TLT_E Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 67.4 32.1 Yes Yes
2 empty 2.3 67.2 28.6 No No
3 empty 2.29 64.7 29 No No
4 empty 1.99 58.7 24.4 No No
5 empty 1.76 67.3 16.9 No No
6 empty .72 72.5 15.5 No No
7 empty 2.44 61.3 15.9 No No
8 empty .47 68.8 19.7 No No
9 empty 2.71 57.8 14.6 No No
10 empty 2.7 72.8 9.3 No No
5HEG_E Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 68.4 32.6 Yes Yes
2 empty 2.12 66.3 25.2 No No
3 empty 2.3 62.2 27 No No
4 empty 1.2 70.1 22.1 No No
5 empty 2.47 71.4 16.9 No No
6 empty 2.22 45.1 13.5 No No
7 empty 2.1 71.6 15 No No
8 empty 2.44 65.5 16.9 No No
9 empty 2.36 56.9 15.2 No No
10 empty 2.07 76.6 8.3 No No
3UU5_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 66.4 29.7 Yes No
2 bound 1.86 61.4 33.9 No No
3 empty 2.1 64.2 25.7 No No
4 empty 1.78 69.1 20 No No
5 empty 2.35 62 14.8 No No
6 empty 2.49 67 12.7 No No
7 empty 2.01 68.5 19.4 No No
8 empty 2.65 71.3 8.7 No No
9 empty 2.33 58 11.7 No No
10 empty 2.37 63.1 13.1 No No
4ILA_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.46 65.5 30.8 Yes No
2 bound 1.94 64.4 35.8 No No
3 empty 2.06 64.1 24.5 No No
4 empty 1.76 73.2 13.6 No No
5 empty 2.46 69.9 17.6 No No
6 empty .55 68.1 16.1 No No
7 empty 2.22 73.2 18 No No
8 empty 2.56 65 12 No No
9 empty 2.55 64.4 12.7 No No
10 bound 2.04 61.3 15.2 No No
3TLU_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 65.9 35.3 Yes No
2 empty 2.46 66.9 30.9 No No
3 empty 2.19 61.4 24.5 No No
4 empty 2.37 68.7 13.7 No No
5 empty .73 67.5 12.9 No No
6 empty .54 66.7 26.1 No No
7 empty 2.1 73.1 15.9 No No
8 empty 2.71 73.6 10.2 No No
9 empty 2.59 63.2 12.4 No No
10 empty 2.05 60 13.8 No No
6HYX_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.43 64.8 34.3 Yes No
2 empty 2.05 62.9 38 No No
3 empty 2 71.9 17.1 No No
4 empty 2.2 67.3 11.3 No No
5 empty .73 70.8 13.5 No No
6 empty 1.53 72.3 10.5 No No
7 empty 2.47 61.6 16.3 No No
8 empty 2.42 67.5 18.5 No No
9 empty 2.72 73.8 8.9 No No
10 empty 2.13 64.1 10.9 No No
2XQ7_D Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.42 67 38.3 Yes Yes
2 empty 2.34 67.5 29.4 No No
3 empty 2.46 62.9 31.2 No No
4 empty 1.82 75 12.5 No No
5 empty 1.41 64.1 16.7 No No
6 empty 2.53 64.4 10.7 No No
7 empty 2.73 70.7 9.3 No No
8 empty 1.99 75.9 12.1 No No
9 empty 2.13 65.7 11.5 No No
10 empty .5 62.2 13 No No
4IL4_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 66.2 41.4 Yes Yes
2 bound 2.43 63.7 28.9 No No
3 empty 1.93 75.4 11.8 No No
4 empty 2.35 69.5 17.3 No No
5 empty 2.4 72.1 18.5 No No
6 empty 2.57 61.5 12.4 No No
7 bound 2.03 55.2 14.8 No No
8 empty 1.83 58.3 12.8 No No
9 empty 2.27 63.9 12.2 No No
10 empty 2.61 57.4 11.7 No No
6HYR_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.44 64.4 33 Yes No
2 empty 2.24 67.3 26.9 No No
3 empty 2.34 67.5 28.4 No No
4 empty 1.84 71.3 12.6 No No
5 empty .97 64.3 16.6 No No
6 empty .73 68.5 15.1 No No
7 empty 2.45 59.8 14.7 No No
8 empty 1.91 66.7 18.3 No No
9 empty 2.58 67.1 9.2 No No
10 empty 2.14 57.9 12.1 No No
6HYZ_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.27 66.2 28.1 Yes No
2 empty 2.09 63.4 25 No No
3 empty 1.77 69.3 15.9 No No
4 empty 2.2 61.9 24.5 No No
5 bound .79 68.8 17.7 No No
6 empty 2.08 72.4 18 No No
7 empty 2.42 60.9 12.6 No No
8 empty 1.69 63.6 16.7 No No
9 empty 2.53 57.8 19.4 No No
10 empty 2.45 58.2 14.5 No No
2XQ6_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 65.3 29.7 Yes No
2 empty 1.93 64 28.5 No No
3 empty 2.04 64.6 24.8 No No
4 empty 1.74 75.5 13.8 No No
5 empty 2.3 72 13.7 No No
6 empty 1.24 66.9 21.2 No No
7 empty 2.06 52.2 19.4 No No
8 empty 2.55 61.2 14.9 No No
9 empty 2.79 65.8 11.9 No No
10 empty 1.97 62.5 13.3 No No
3TLV_D Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 68.7 34.5 Yes Yes
2 empty 2.18 67.4 25 No No
3 empty .66 70.9 17.7 No No
4 empty 2.28 70.6 19.8 No No
5 empty 2.7 68.9 10 No No
6 empty 2.59 58.7 15 No No
7 empty 2.47 55.8 13.3 No No
8 empty 2.29 60 11.9 No No
9 empty .43 64.4 10.9 No No
10 empty 2.18 60.8 12.2 No No
6HYA_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 63.6 44.1 Yes No
2 empty 2.42 63.1 30.1 No No
3 empty 1.8 71 16.7 No No
4 empty .68 65.4 17.2 No No
5 empty 2.38 66.4 18.3 No No
6 empty 2.03 59.7 12.8 No No
7 empty 2.13 57.7 15.9 No No
8 empty 2.91 68.4 7.7 No No
9 empty 2.48 61.3 12 No No
10 empty 2.47 53.5 10.6 No No
4NPP_A Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.72 66.2 39.4 Yes Yes
2 empty 2.3 65 28 No No
3 empty 2.03 64.5 22.8 No No
4 empty 1.84 74.5 15.8 No No
5 empty 2.09 68.1 16.6 No No
6 empty 1.86 72.9 18.1 No No
7 empty 2.64 65.1 11.8 No No
8 empty 1.83 55.2 14.1 No No
9 empty 2.45 63.9 11.4 No No
10 empty 2.54 57.3 11.5 No No
6HY9_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 65.8 35.6 Yes No
2 empty 2.31 62.9 34.8 No No
3 empty 2.12 60.1 26.1 No No
4 empty 1.84 71.6 13.2 No No
5 empty .68 65.9 20.9 No No
6 empty 2.24 66.9 21.5 No No
7 empty .5 68.2 19.6 No No
8 empty 2.38 62.4 19.7 No No
9 empty 2.09 61 12.6 No No
10 empty 2.67 69.1 9.2 No No
6F0Z_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.48 64.7 34.4 Yes No
2 empty 1.84 64.1 44.4 No No
3 empty 2.15 63.3 27.2 No No
4 empty 1.8 69.1 17.9 No No
5 empty 1.84 70.6 13.5 No No
6 empty .73 66.3 13.8 No No
7 empty 2.55 63.1 12.9 No No
8 empty 1.78 57.9 11.1 No No
9 empty 2.24 55.3 12.4 No No
10 empty 2.37 64.1 8.2 No No
4IL9_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 63.4 39 Yes No
2 bound 2.44 66.5 30.3 No No
3 empty 2.26 71.3 27.2 No No
4 empty 1.8 71.9 18.4 No No
5 bound .71 67.8 14.9 No No
6 empty 2.74 69.2 10.1 No No
7 bound 2.02 60.1 15.5 No No
8 empty 2.39 55.7 11 No No
9 empty 1.74 55.7 14.1 No No
10 empty 2.39 67.5 9.4 No No
3UU4_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.41 63.1 36.5 Yes No
2 empty 2.19 64.9 29.6 No No
3 empty 2 65.6 33.9 No No
4 empty 1.75 70.3 13.7 No No
5 empty 2.45 73.2 10.9 No No
6 empty .67 67.5 13.2 No No
7 empty 2.13 73.4 15.4 No No
8 empty 2.57 70.8 9.6 No No
9 empty 2.32 56.1 10.5 No No
10 empty 2.02 65.8 13.2 No No
6HYW_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 65.3 39.7 Yes No
2 bound 2.18 66.4 21.8 No No
3 empty 2.08 62.6 26.7 No No
4 empty 1.8 75.8 12.3 No No
5 empty 2.25 65.8 19.1 No No
6 bound .71 66.6 17.7 No No
7 empty 2.44 59.5 14.5 No No
8 empty 1.7 57.8 9.4 No No
9 empty 2.25 54.5 12.1 No No
10 empty 2.57 62.3 11.6 No No
5HCJ_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 65.4 33.9 Yes No
2 empty 2.29 67.6 28.1 No No
3 empty 2.31 65.5 27.1 No No
4 empty 1.26 69.1 20.7 No No
5 empty .56 69 19 No No
6 empty 2.45 63.7 15.4 No No
7 empty 2.62 70.5 10.9 No No
8 empty 2.31 58.2 12.2 No No
9 empty 2.43 61.2 12.2 No No
10 empty 2.59 52.9 9.9 No No
4HFH_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.75 65 40 Yes No
2 bound 2.4 65.1 34.5 No No
3 bound 2.08 65.2 26.8 No No
4 empty 1.79 69.7 17.8 No No
5 empty 2.35 71.5 16.7 No No
6 empty 2.19 77.8 12.5 No No
7 empty 2.62 64.6 11.7 No No
8 empty 1.85 59 12.6 No No
9 empty 2.4 63.3 11.7 No No
10 empty 2.88 61.1 10.5 No No
4NPQ_O Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 65.9 28.9 Yes No
2 empty 2.1 64.8 29.4 No No
3 empty 2.23 64.3 27.2 No No
4 empty 1.87 71.9 18.1 No No
5 empty 1.74 71.1 12.6 No No
6 empty 2.03 65.7 16.1 No No
7 empty 1.61 65.9 17.9 No No
8 empty 1.05 64.2 20.5 No No
9 empty .35 65.2 13.2 No No
10 empty .92 66.5 8.6 No No
3UU6_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 64.5 37.2 Yes No
2 empty 2.47 63.8 33.8 No No
3 empty 2.12 64.3 26.8 No No
4 empty 2.39 69.1 14.9 No No
5 bound .76 62 16.5 No No
6 empty 2.31 72.7 18.4 No No
7 empty 2.68 68.4 12.2 No No
8 empty 2.27 57.8 11 No No
9 empty 2.51 58.6 12.6 No No
10 empty .45 64.7 11.9 No No
5MZR_E Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 67.5 39.4 Yes Yes
2 bound 2.4 65.2 33.4 No No
3 empty 2.23 64 26.7 No No
4 empty 1.55 65.5 16.7 No No
5 empty 1.94 73 15.5 No No
6 empty 2.28 69.3 18.8 No No
7 empty 2.52 59 20.5 No No
8 empty 2.64 67.2 12.1 No No
9 empty 2.36 52.1 13.2 No No
10 empty 2.56 63.3 12.5 No No
6HJZ_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 64.4 42.6 Yes No
2 bound 2.31 65 29.8 No No
3 empty 1.83 68.1 18.6 No No
4 empty 2.05 71.5 15.5 No No
5 bound .71 64.4 15.8 No No
6 empty 2.41 60.5 16.5 No No
7 empty 2.08 75.8 10.6 No No
8 empty 2.73 75.2 9.5 No No
9 empty 1.8 55.3 12.6 No No
10 empty 2.33 58.6 12.4 No No
4LMK_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 64.8 41 Yes No
2 empty 2.44 63.5 29.8 No No
3 empty 2.25 69.6 25.3 No No
4 empty .81 68.2 15.8 No No
5 empty 2.49 63.5 18 No No
6 empty 2.26 66.4 17.2 No No
7 empty 2.01 75.4 9.1 No No
8 empty 2.39 52.5 14.6 No No
9 empty 2.61 74.6 8.6 No No
10 empty 2.41 72.4 6.1 No No
6F11_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.44 65.4 29.7 Yes No
2 empty 2.01 61.9 37.6 No No
3 empty 2.14 62.6 26.7 No No
4 empty 1.81 73.7 15.8 No No
5 empty 2.27 68.4 13.2 No No
6 empty .78 65.4 13.7 No No
7 empty 1.91 57.7 13.8 No No
8 empty 1.7 55.2 14 No No
9 empty 1.96 73 12.9 No No
10 empty 2.17 62.2 10 No No
5OSA_E Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 68.2 21 No No
2 empty 2.06 67 22.1 No No
3 empty 2.32 68.6 19.8 No No
4 empty 2.28 62.9 15.5 No No
5 empty 2.47 53.7 15.8 No No
6 empty 2.11 57.7 21.3 No No
7 empty 2.08 71 17.4 No No
8 empty 2.55 61 13.9 No No
9 empty 2.69 69.8 11.2 No No
10 empty 2.13 61.5 11.9 No No
5NKJ_E Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 68.7 33.5 Yes Yes
2 empty 2.38 67.2 28.5 No No
3 empty 2.25 63.9 26.3 No No
4 empty 2.07 66.4 22.4 No No
5 empty 2.37 60.7 26.5 No No
6 empty 2.46 61.1 17.2 No No
7 empty .59 67.2 15.2 No No
8 empty 2 61.3 14.7 No No
9 empty 1.95 61.5 13.1 No No
10 empty 2.68 69.4 9.8 No No
4LML_C Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 67.9 22.2 No No
2 empty 2.03 62.3 30.1 No No
3 empty 2.19 67.3 25.1 No No
4 empty 2.39 68.5 29.3 No No
5 empty 1.6 75 14.6 No No
6 empty .68 66.7 13.4 No No
7 empty 2.44 61.8 14.1 No No
8 empty 2.45 63.4 11.2 No No
9 empty 2.64 65.6 12.2 No No
10 empty 2.04 62 13.9 No No
3UU8_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 65.9 38.6 Yes No
2 empty 2.08 63.9 26.8 No No
3 empty 2.24 67.2 22 No No
4 empty 1.7 69.3 16.6 No No
5 empty 2.17 64.4 14.4 No No
6 bound .73 65.2 18.9 No No
7 empty 2.34 57.5 15.4 No No
8 empty 2.03 76.1 11.1 No No
9 empty 2.65 64.1 10.5 No No
10 empty 2.32 63.2 11.4 No No
6F0N_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.16 63 37.4 Yes No
2 bound 2.38 66.4 29.3 No No
3 empty 1.89 74.7 12.3 No No
4 bound .68 71.1 17 No No
5 empty 1.93 69.7 13.4 No No
6 empty 2.05 72.8 12.5 No No
7 empty 2.64 64.8 12.2 No No
8 empty 1.69 59.5 11.3 No No
9 empty 2.22 56.4 11.1 No No
10 empty 2.09 56 14.5 No No
5MZT_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 65.6 37.5 Yes No
2 bound 2.19 65.4 21.7 No No
3 bound 2.08 66.9 27 No No
4 empty 1.76 71 16.4 No No
5 empty 2.61 65 16.1 No No
6 empty 1.93 75.9 15.5 No No
7 empty 2.5 59.4 13.9 No No
8 empty 2.14 71.9 14 No No
9 empty 2.59 67.7 9.5 No No
10 empty 2.47 63 14.7 No No
3TLT_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.43 64.4 32.5 Yes No
2 empty 2.1 70.1 20 No No
3 empty 1.83 61.8 27.9 No No
4 empty 1.74 64.7 17.7 No No
5 empty 2.28 75.4 12.6 No No
6 empty .52 68.3 24.1 No No
7 empty 2.39 68.7 19.8 No No
8 empty 2.81 73.6 10.1 No No
9 empty 2.31 66 14.2 No No
10 empty 1.77 60.9 13.7 No No
4HFI_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 65.8 37.7 Yes No
2 bound 2.41 66.8 30.6 No No
3 empty 2.1 63.8 26.4 No No
4 empty 2.27 71.2 30.6 No No
5 empty 1.79 75.1 15.9 No No
6 empty 2.68 69.3 9.8 No No
7 bound 2.01 60 13.9 No No
8 empty 2.27 52.9 12.2 No No
9 empty 2.41 59.5 13.9 No No
10 empty 1.8 56.2 15.8 No No
6HJA_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.43 64.8 35.1 Yes No
2 bound 1.94 63.5 39.2 No No
3 empty 2.14 63.3 25.1 No No
4 empty 1.78 70.6 19.6 No No
5 empty 2.28 70.5 24.5 No No
6 bound .77 74.3 15.2 No No
7 empty 2.67 72 9.7 No No
8 empty 2.58 66.8 7.3 No No
9 empty 2.35 58.1 11 No No
10 empty .26 61.6 13.8 No No
6HPP_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 64.1 38.8 Yes No
2 bound 2.29 65.6 27.6 No No
3 empty 1.82 70 17.6 No No
4 empty 1.29 68.8 21 No No
5 empty 2.15 64.6 25.3 No No
6 empty 2.3 58.2 14 No No
7 empty 2.58 65.6 12.1 No No
8 empty 2.62 61.7 17.5 No No
9 empty 2.33 62.2 11.7 No No
10 empty 1.94 55.2 14 No No
6HJZ_G Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 62.4 37.4 Yes No
2 bound 2.26 66.9 27.7 No No
3 empty 1.82 66.6 20 No No
4 empty 2.06 63.2 26.6 No No
5 empty 2.34 69.1 16.2 No No
6 bound .71 70.9 16 No No
7 empty 2.32 63.2 13.6 No No
8 empty 2.61 72.6 10 No No
9 empty 2.05 72.4 11.3 No No
10 empty 2.37 63 8.6 No No
4ILC_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.32 61.2 35.5 Yes No
2 bound 2.51 66.9 30.4 No No
3 empty 1.84 72.6 15.7 No No
4 empty 2.03 63.1 23.2 No No
5 bound .66 71.1 16.5 No No
6 empty 2.34 69.4 20.7 No No
7 empty .34 67.6 17.5 No No
8 empty 2.57 68.9 9.3 No No
9 bound 2.04 60.4 14.9 No No
10 empty 2.53 62.5 11.5 No No
4YEU_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.28 70.9 28.9 Yes No
2 empty 1.78 67.7 21.9 No No
3 empty 1.91 61.1 23.6 No No
4 empty 2.16 60.3 18.9 No No
5 empty .82 67.9 19.4 No No
6 empty 1.88 65.5 22.8 No No
7 empty 2.57 63.9 22.1 No No
8 empty 2.4 59.8 12.6 No No
9 empty 2.36 76.3 11.4 No No
10 empty 1.6 67.3 9.4 No No
5L4H_A Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 68.9 36 Yes Yes
2 empty 1.87 66.1 42.8 No No
3 empty 2.32 66.7 29.2 No No
4 empty 1.86 75.8 13 No No
5 empty 2.6 72.5 10.1 No No
6 empty 2.47 60.5 15.7 No No
7 empty 1.97 70.6 14 No No
8 empty 2.32 65.4 19.6 No No
9 empty 2.47 66.5 10.9 No No
10 empty 2.35 55.5 11.1 No No
5MZR_A Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.75 66.7 39.4 Yes Yes
2 bound 2.5 66 28.7 No No
3 empty 2.15 63.6 26.6 No No
4 empty 1.65 69.1 15.7 No No
5 empty 2.35 70.3 13.9 No No
6 empty 2.04 73.3 12.5 No No
7 empty 1.78 53.7 15.3 No No
8 empty 2.55 59.4 16.3 No No
9 empty 2.61 64.6 11.4 No No
10 empty 1.88 61 13.7 No No
3UU6_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 66.5 25.1 Yes No
2 empty 2.1 64.5 26.6 No No
3 empty 1.75 72 15.2 No No
4 bound 2.24 60 26.3 No No
5 empty 1.45 65 33.5 No No
6 empty 2.27 56.6 14.9 No No
7 empty 2.31 71.8 13.9 No No
8 empty 2.01 75.1 17.1 No No
9 bound .77 72 13.6 No No
10 empty 2.71 74.2 10.9 No No
6F0M_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.4 65.1 29.7 Yes No
2 bound 1.99 64.1 44.3 No No
3 empty 2.11 64.6 25.3 No No
4 empty 1.79 69.1 18.8 No No
5 empty 2.28 69.7 16 No No
6 bound 1.02 70.8 13.4 No No
7 empty 2.11 75.7 14.3 No No
8 empty 2.58 65.6 11.6 No No
9 bound 1.91 56.4 15.8 No No
10 empty 2.22 54.8 11.1 No No
4NPQ_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 67 37.9 Yes Yes
2 empty 2.08 68.8 31.6 No No
3 empty 2.01 63.8 21.9 No No
4 empty 1.64 68.9 12.6 No No
5 empty .99 66.4 20.7 No No
6 empty .9 69 13.9 No No
7 empty 2.05 68.2 15.6 No No
8 empty 2.12 56.6 14 No No
9 empty 1.89 76.6 11.4 No No
10 empty .89 66.5 9.6 No No
4IL4_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.38 66 34.7 Yes No
2 empty 1.87 63.3 36.5 No No
3 empty 2.11 60.9 26.1 No No
4 empty 1.72 70.4 16.2 No No
5 empty 1.47 63 23.1 No No
6 empty 2.39 67.4 14.3 No No
7 empty 2.09 76.9 11.8 No No
8 empty 2.49 66 11.4 No No
9 empty 1.71 58.5 12.7 No No
10 empty 2.37 64.5 7.9 No No
5HEH_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 64.8 32.6 Yes No
2 empty 2.36 64.5 29.9 No No
3 empty 2.27 65.8 29.8 No No
4 empty 1.72 75.6 13.9 No No
5 empty 1.01 67.8 18 No No
6 empty .41 68.5 14.3 No No
7 empty 2.54 62.9 11.9 No No
8 empty 2.72 69.6 12.5 No No
9 empty 2.31 67.5 11.3 No No
10 empty 2.34 66.1 15.2 No No
3TLW_E Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.64 71.2 32.3 Yes Yes
2 empty 2.44 67.2 29.9 No No
3 empty 2.15 66.3 25.8 No No
4 empty 2.22 61.6 24.6 No No
5 empty 1.88 70.5 14.4 No No
6 empty .34 66.1 15.8 No No
7 empty 2.69 75.5 9.6 No No
8 empty 2.07 62.2 14.3 No No
9 empty 2.13 58.6 15.4 No No
10 empty 2.58 63.1 10.3 No No
4ZZC_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.43 64.2 35 Yes No
2 bound 1.88 65.3 33.3 No No
3 empty 2.07 65.2 26.5 No No
4 empty 1.74 70.3 16 No No
5 empty 2.37 59.4 24.1 No No
6 empty 2.17 69.8 17.5 No No
7 empty .47 68.4 19.3 No No
8 empty 2.54 65.1 10.6 No No
9 empty 2.66 61.2 12.9 No No
10 empty 2.51 62.5 10.6 No No
4F8H_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 64.4 41.7 Yes No
2 empty 2.24 66.9 27.4 No No
3 empty 1.98 71.4 15 No No
4 empty 2.41 58.8 16.1 No No
5 empty 2.26 74.8 12.8 No No
6 empty 2.14 67 18.6 No No
7 empty 2.72 70.1 11 No No
8 empty 2.46 67 8.8 No No
9 empty 2.61 63.7 10.8 No No
10 empty 2.31 60.6 12.7 No No
5MUO_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 68.9 35.4 Yes Yes
2 empty 2.22 63.9 27.5 No No
3 empty 2.12 65 24.2 No No
4 empty 2.18 70.2 19.8 No No
5 empty 2.43 70.4 19.7 No No
6 empty .48 67.9 10 No No
7 empty 2.38 61.7 14.9 No No
8 empty 2.42 60.3 12.1 No No
9 empty 2.75 72.1 10 No No
10 empty 2.34 64.1 10.6 No No
4HFD_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 61.5 35.9 Yes No
2 bound 2.47 64.4 31.5 No No
3 empty 1.73 68.5 16.7 No No
4 bound 1.39 73.5 21.9 No No
5 empty 2.38 68 18.2 No No
6 empty 2.04 70.1 18.1 No No
7 empty 2.71 60.3 13.6 No No
8 empty .34 66.8 19.3 No No
9 empty 2.7 67.9 10.5 No No
10 bound 1.76 76.5 13.3 No No
5IUX_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.17 65 36.8 Yes No
2 bound 2.35 63.5 30.7 No No
3 empty 1.91 74.9 11.8 No No
4 empty 2.4 61.8 25.3 No No
5 empty 2.36 71 18.9 No No
6 bound .72 65.6 15.6 No No
7 empty 2.5 60.7 17.6 No No
8 empty 2.72 66.5 12.9 No No
9 bound 1.96 60.7 14.1 No No
10 empty 2.4 62.9 11.5 No No
3UUB_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.52 64.3 34 Yes No
2 empty 1.91 63.7 33 No No
3 bound 2.09 62.8 27.2 No No
4 empty 1.81 65.8 19.7 No No
5 empty 2.45 71.8 12.6 No No
6 bound .67 65.7 11.4 No No
7 empty 2.24 56.1 11.6 No No
8 empty 2.92 72.3 9.7 No No
9 empty 2.48 63.4 7.7 No No
10 empty 2.42 58.6 10.9 No No
3IGQ_D Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 68.1 21.6 No No
2 empty 2.4 67.2 20.1 No No
3 empty 2.64 56.2 24.4 No No
4 empty 2.45 58.5 14.7 No No
5 empty 2.08 60.9 10.5 No No
6 empty 2.42 60.7 10.7 No No
7 empty 2.86 69.3 8.7 No No
8 empty 2.24 50.9 9 No No
9 empty 1.64 69.3 11.6 No No
10 empty 2.46 62.5 9.2 No No
5HCM_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.48 73.4 32 Yes Yes
2 empty 2.3 65 27.3 No No
3 empty 2.14 63.9 25.9 No No
4 empty 2.2 61 23 No No
5 empty 2.23 68.7 22.5 No No
6 empty .35 68.5 17.7 No No
7 empty 2.41 61.8 14.8 No No
8 empty 2.3 67.9 19.1 No No
9 empty 2.69 70.8 9.6 No No
10 empty 2.3 68.4 11.6 No No
6HZ3_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 66.5 44.2 Yes Yes
2 empty 2.48 64.7 33.5 No No
3 empty .51 71.8 13.8 No No
4 empty 2.17 64.5 17.9 No No
5 empty 1.83 73.5 11.6 No No
6 empty 2.7 65.5 12.1 No No
7 empty 1.9 62.9 14.4 No No
8 empty 2.36 62.3 10.4 No No
9 empty 2.21 60.5 13.4 No No
10 empty 2.51 74.4 9.7 No No
3TLU_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 65.3 31.7 Yes No
2 empty 2.42 65.3 34 No No
3 empty 2.22 62.3 25 No No
4 empty 2.27 69.8 23.4 No No
5 empty .97 65.5 20.1 No No
6 empty 2.67 69.8 9.5 No No
7 empty 2.54 57.1 12.4 No No
8 empty .41 63.5 12.4 No No
9 empty 2.35 59.1 11 No No
10 empty 2.23 52.5 11.9 No No
6F12_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.43 65.9 30.9 Yes No
2 empty 1.68 63.9 34.5 No No
3 empty 2.14 63.2 27.1 No No
4 empty 1.79 70.9 18.4 No No
5 empty 2.23 62.1 14.8 No No
6 empty 1.7 57.3 13.3 No No
7 empty 2.62 67.3 8.9 No No
8 empty 2.2 54.4 11.9 No No
9 empty 2.22 60.8 12 No No
10 empty 2.34 63.1 8.6 No No
4QH1_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 63.6 40.3 Yes No
2 bound 2.42 65.2 30.5 No No
3 empty 1.79 71.9 18.3 No No
4 empty 1.95 76.1 15.3 No No
5 empty 2.11 78.1 15.1 No No
6 empty 2.55 65.4 11.9 No No
7 bound 2.02 57.5 15.5 No No
8 empty 2.36 63 7.6 No No
9 empty 1.75 53.6 13.6 No No
10 empty 2.27 58.7 10.6 No No
6HY5_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 64.8 41.3 Yes No
2 bound 2.49 63.8 32.2 No No
3 empty 1.79 75.4 12.6 No No
4 empty 1.77 63.4 19.2 No No
5 empty 2.32 69.4 21.1 No No
6 empty 2.11 70.4 18.5 No No
7 empty 2.6 70 9.2 No No
8 empty 2.22 64.1 14.2 No No
9 empty 1.89 57.9 12.9 No No
10 empty 2.41 59.6 12.1 No No
4ZZB_E Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 66.3 36.9 Yes Yes
2 bound 2.42 68.9 29.1 No No
3 empty 2.05 64.5 21.1 No No
4 empty 2.07 74.2 14.6 No No
5 empty 2.68 71.4 11.1 No No
6 empty .49 65.9 20.1 No No
7 empty 2.77 61.3 14.3 No No
8 empty 2.37 61.2 11.8 No No
9 empty 2.13 58.7 13.6 No No
10 empty 1.81 54.7 15.3 No No
4IRE_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.38 65 35.2 Yes No
2 bound 1.87 61.2 57.2 No No
3 bound 2.15 66 26.2 No No
4 empty 1.84 74.5 14.7 No No
5 bound 1.4 62 18.5 No No
6 empty 2.04 54.1 12.3 No No
7 empty 2.19 64.9 13.3 No No
8 empty 2.56 65.2 8.1 No No
9 empty 2.65 74.7 9.9 No No
10 empty 1.82 68.9 15.2 No No
4HFC_D Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 66.3 34 Yes Yes
2 bound 2.48 65 34.8 No No
3 empty 1.83 69 16.5 No No
4 empty 2.32 63.1 20 No No
5 empty .35 66.2 16.4 No No
6 empty 2.65 69.6 9.9 No No
7 empty 1.79 69 12.7 No No
8 empty 2.29 59.6 11.4 No No
9 empty 2.23 59.9 13.4 No No
10 empty 2.08 66.4 10.5 No No
4ILA_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.27 60.4 33.5 Yes No
2 bound 2.22 66.6 27.2 No No
3 empty 1.65 73.4 14.6 No No
4 empty 2.36 66 18.3 No No
5 bound 1.04 66.1 14.5 No No
6 empty 2.15 73.3 15.4 No No
7 empty .32 68.2 16.2 No No
8 empty 2.64 59.4 15.7 No No
9 empty 2.41 60.4 16.2 No No
10 empty 2.55 66.8 11.3 No No
6EMX_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.04 65.4 43.3 Yes No
2 empty 2.35 66.6 23.2 No No
3 empty 1.77 69.7 16.5 No No
4 empty 2.38 66.5 12.9 No No
5 empty 2.37 61.9 16.7 No No
6 empty 2.15 65.1 19.9 No No
7 empty 2.76 75.4 9.2 No No
8 empty 2.52 63.6 17.4 No No
9 empty 2.38 61.5 12.3 No No
10 empty 1.74 57.8 13.6 No No
6HZ1_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.44 64.2 30.2 Yes No
2 bound 1.97 63.6 38.3 No No
3 empty 2.17 71.8 29.8 No No
4 empty 2.12 62 26.4 No No
5 empty 1.66 70.1 16.5 No No
6 bound .77 63.2 16.3 No No
7 empty 2.72 71.5 9.5 No No
8 empty 2 59.2 13.4 No No
9 empty 2.19 50.6 12.7 No No
10 empty 1.79 57.7 14.9 No No
4NPQ_K Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 64.2 31.8 Yes No
2 empty 2.17 66.3 28.7 No No
3 empty 2 72.2 24.6 No No
4 empty 1.98 63.2 29.1 No No
5 empty 1.79 74.8 18.3 No No
6 empty 1.77 72.7 9.9 No No
7 empty 1.02 68.7 20.4 No No
8 empty .48 66.7 11.8 No No
9 empty .89 64.2 9.3 No No
10 empty 2.5 70.7 8.9 No No
3EI0_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 64.7 28.9 Yes No
2 empty 1.92 63.8 37.4 No No
3 empty 2.3 66.2 25.3 No No
4 empty 2.2 70.9 27.8 No No
5 empty 1.69 72.8 13.8 No No
6 empty .86 69.8 13.4 No No
7 empty 2.3 50.9 13.8 No No
8 empty 2.79 72.8 9 No No
9 empty 1.85 78.9 6.7 No No
10 empty 2.19 61.8 17.2 No No
5IUX_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.45 63.8 33.5 Yes No
2 bound 1.85 65.3 33.9 No No
3 bound 2.17 64.1 26.6 No No
4 empty 1.91 74.3 12.5 No No
5 empty 2.4 71.4 12.7 No No
6 bound .67 67.2 12.8 No No
7 empty 2.12 70.4 18.6 No No
8 empty 2.31 56.8 11.7 No No
9 empty 2.56 65.3 9.5 No No
10 empty 2.29 65.2 10.5 No No
4QH1_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 63.3 44.3 Yes No
2 bound 2.5 65.2 28.7 No No
3 empty 1.78 72.9 15 No No
4 empty 2.34 65.6 19 No No
5 empty .72 64.4 16.9 No No
6 empty 2.05 72.8 11.9 No No
7 empty 2.68 60.6 15.7 No No
8 empty 2.64 65.1 11.5 No No
9 empty 2.52 66.5 10.6 No No
10 bound 2.01 62.9 12.5 No No
6HJI_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 64.4 39.5 Yes No
2 empty 2.43 65.1 29.5 No No
3 empty 2.11 64.4 26.9 No No
4 empty 1.8 72.7 16.3 No No
5 empty 2.3 68.8 19.9 No No
6 empty 2.39 65.2 20.1 No No
7 empty 2.58 67 9.5 No No
8 empty 2.24 62.7 11.1 No No
9 empty 2.48 57 11.5 No No
10 empty 1.88 53.6 15.1 No No
5MUR_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 64 32.4 Yes No
2 bound 2.49 64.8 30.2 No No
3 bound 1.47 74.1 25.4 No No
4 empty 1.93 76.7 11.6 No No
5 empty 2.47 66.4 22.8 No No
6 empty 2.71 63.8 12.4 No No
7 empty .5 70.9 9.4 No No
8 empty 2.43 59.3 10.5 No No
9 empty 2.44 62 12 No No
10 empty 1.83 57 14.2 No No
3TLU_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 65.5 30.3 Yes No
2 empty 2.43 66.1 34.5 No No
3 empty 1.93 63.1 36.3 No No
4 empty 2.34 71.6 28.6 No No
5 empty .55 64.9 24.7 No No
6 empty 2.62 68.7 10.7 No No
7 empty 2.44 59.2 18.9 No No
8 empty 2.33 60.2 10.5 No No
9 empty 1.88 69.7 11.1 No No
10 empty 2.21 50.6 10 No No
6HZ1_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 62.9 45.6 Yes No
2 bound 2.34 64.8 26.9 No No
3 empty 1.63 68.8 18.1 No No
4 empty 2.38 70.3 13.8 No No
5 empty 2.49 57.5 16.1 No No
6 empty 2.05 72.3 11 No No
7 bound .77 65.6 12.3 No No
8 empty 2.59 64.4 12.1 No No
9 empty 1.72 61.1 13.2 No No
10 empty 2.38 65.9 8.2 No No
6F11_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.46 66.1 30.1 Yes No
2 empty 1.96 62.2 39.8 No No
3 empty 2.17 64.2 26.2 No No
4 empty 1.81 70.8 17.7 No No
5 empty 2.21 64.6 17.1 No No
6 empty .79 65.8 15.2 No No
7 empty 2.07 72.4 11.1 No No
8 empty 1.82 57.8 14.4 No No
9 empty 2 55.5 13 No No
10 empty 2.23 66.4 10.7 No No
6HJI_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 66.3 30 Yes No
2 empty 2.13 62.4 26.8 No No
3 empty 2.12 60.1 24.1 No No
4 empty 1.86 70.8 17.3 No No
5 bound 1.43 69.4 20.1 No No
6 empty 2.37 67.2 16.6 No No
7 empty 2.23 69.9 13.5 No No
8 empty 2.62 69.1 10.7 No No
9 empty 1.74 60.8 14.9 No No
10 empty .33 64.5 19.4 No No
6F13_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 65.2 40.5 Yes No
2 empty 2.18 62 25.5 No No
3 empty 1.89 75 12.1 No No
4 bound 2.04 68.9 20.6 No No
5 empty 2.2 65.5 16.7 No No
6 empty 2.61 58 17.2 No No
7 empty 2.42 63.4 14.7 No No
8 empty 2.28 66.4 20.1 No No
9 empty 2.58 71.1 9.5 No No
10 bound 2.13 59.3 12.9 No No
4LMK_B Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 66.5 40.6 Yes Yes
2 empty 2.4 68.5 29.8 No No
3 empty 2.08 62.7 24.3 No No
4 empty 2.25 67.4 23.2 No No
5 empty .82 69 17.5 No No
6 empty 2.33 70.9 14.1 No No
7 empty 2 76.5 10 No No
8 empty 2.22 59 14.4 No No
9 empty 2.68 65.2 13.3 No No
10 empty 2.52 49.4 12.2 No No
4ILB_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 63.8 37.3 Yes No
2 bound 2.27 65.5 27.3 No No
3 empty 2.14 62.5 26.1 No No
4 empty 1.8 70.6 15.8 No No
5 empty 2.35 65.4 17.9 No No
6 empty 2.34 67.8 20.7 No No
7 empty 2.68 70.3 9.2 No No
8 empty 2.42 61.4 13.9 No No
9 empty 2.67 60.6 13.8 No No
10 empty 2.42 59.8 10.7 No No
4YEU_A Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.77 68.4 21.8 No No
2 empty 1.92 64.9 22.9 No No
3 empty 2.01 76.8 16.1 No No
4 empty 2.25 67.3 18.6 No No
5 empty 2.45 60.5 29.3 No No
6 empty .78 68.6 17.6 No No
7 empty 1.91 70.4 20 No No
8 empty 1.81 69.4 14.3 No No
9 empty 2.62 62.3 17.3 No No
10 empty 2.16 60.4 16.3 No No
3TLT_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.41 65.3 32.2 Yes No
2 empty 2.36 65 28.5 No No
3 empty 2.3 65.4 30.2 No No
4 empty 2.16 62 26 No No
5 empty 1.69 74.7 9.1 No No
6 empty .7 62 18.6 No No
7 empty .47 69.3 14.7 No No
8 empty 2.28 56.8 15.3 No No
9 empty 2.69 72.5 9.9 No No
10 empty 2.35 59.9 11.9 No No
6F0J_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.39 64 33.9 Yes No
2 empty 1.9 62.1 41.1 No No
3 empty 2.17 63.9 27.1 No No
4 empty 1.84 71 15 No No
5 empty 2.24 66.5 20.6 No No
6 empty .71 63.2 15.4 No No
7 empty 2.02 75.6 14.4 No No
8 empty 2.63 64.6 10.5 No No
9 empty 1.78 60.3 14.7 No No
10 empty 2.28 58.7 11.8 No No
3EI0_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.39 62.3 31 Yes No
2 empty 2 63.6 29.2 No No
3 empty 2.24 67 29.2 No No
4 empty 2.12 67 23.7 No No
5 empty 1.7 75.2 14.5 No No
6 empty .89 70.4 14.2 No No
7 empty 2.45 67.3 10 No No
8 empty 2.81 70.6 8.6 No No
9 empty 2.14 63.3 13 No No
10 empty 1.9 80.3 6 No No
6HJB_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.33 62.4 31.9 Yes No
2 empty 2.27 66.7 21.3 No No
3 empty 1.86 68.1 17.3 No No
4 bound .67 71.6 17.6 No No
5 empty 2.04 70.2 12.2 No No
6 empty 2.28 59.3 15 No No
7 empty .52 71.1 13.9 No No
8 empty 2.61 60.8 17.7 No No
9 empty 2.64 64.5 11.8 No No
10 bound 2.12 57.4 14.4 No No
6F16_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 63.5 42.2 Yes No
2 bound 2.33 64.9 29.4 No No
3 empty 1.79 75.6 10.3 No No
4 empty 1.85 70.9 12.6 No No
5 empty 2.09 74.1 10.9 No No
6 empty 2.37 58.6 11.9 No No
7 empty 1.71 59.5 13.7 No No
8 empty 2.55 63.2 11.6 No No
9 bound 1.96 58.7 13.9 No No
10 empty 2.37 63 13.6 No No
5NJY_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.41 64.7 35 Yes No
2 empty 2.07 68.1 21.3 No No
3 empty 2.22 65 25.8 No No
4 empty 2.1 65 20.6 No No
5 empty 1.8 73 11.7 No No
6 empty 2.14 60.9 15.7 No No
7 empty .93 68.5 14.2 No No
8 empty 2.57 61.1 15.8 No No
9 empty .37 70.5 10.8 No No
10 empty .56 69.5 10.6 No No
5V6N_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 64.9 33.8 Yes No
2 empty 2.22 67.4 31.9 No No
3 empty 2.12 67.6 24.2 No No
4 empty 1.75 70.7 15.1 No No
5 empty 1.93 67.2 18.2 No No
6 empty .8 74.5 15.5 No No
7 empty 2.59 60.9 21.3 No No
8 empty 2.33 54.9 16.2 No No
9 empty 2.54 73.5 11.5 No No
10 empty 2.36 62 17.2 No No
4HFI_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 63.5 40.8 Yes No
2 bound 2.5 64.7 34.9 No No
3 empty 1.79 71.7 18.5 No No
4 bound 1.41 72 25.2 No No
5 empty 1.96 73.8 13.5 No No
6 empty 2.21 78.3 12.5 No No
7 empty 2.72 66.2 12.5 No No
8 empty 2.26 66.4 9 No No
9 empty 1.76 54.7 14.5 No No
10 empty 2.45 58.1 10.6 No No
4LMK_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.38 66 28.4 Yes No
2 empty 2.17 62.6 28.3 No No
3 empty 2.12 66.5 26.1 No No
4 empty 1.59 68.3 29 No No
5 empty 2.39 72 21.8 No No
6 empty 1.07 67.6 13.6 No No
7 empty 2.07 76.3 11.3 No No
8 empty 2.53 63.8 9.5 No No
9 empty 2.5 53.2 13.4 No No
10 empty 2.5 64.5 10.1 No No
4F8H_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 68 27.3 Yes No
2 bound 2.16 63.7 26.8 No No
3 bound 1.82 60.6 35.2 No No
4 empty 1.9 71.8 12.8 No No
5 empty 2.45 73.3 11.7 No No
6 bound .74 68.7 15.1 No No
7 empty 2.18 65.7 19.2 No No
8 empty 2.37 62.6 15.6 No No
9 empty 2.74 69.6 9.5 No No
10 empty 2.48 64.3 8.3 No No
5MVN_E Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 66.8 37.1 Yes Yes
2 bound 2.35 64.1 35.4 No No
3 empty 1.95 63.4 25.9 No No
4 empty 1.76 73.4 16.9 No No
5 empty 2.42 68.5 19.7 No No
6 empty .52 68.8 13.9 No No
7 empty 2.21 67.1 17.3 No No
8 empty 2.55 70.7 10 No No
9 empty 2.42 63.4 16.6 No No
10 empty 1.73 54.3 14.2 No No
3UUB_I Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 63 37.9 Yes No
2 empty 2.48 65.3 28.5 No No
3 empty 2.06 63.9 26.9 No No
4 empty 1.85 78.3 11.4 No No
5 empty 2.48 70.3 14.3 No No
6 empty 2.26 68.9 18.6 No No
7 empty 2.71 70.2 8.4 No No
8 empty 2.22 58.6 11.9 No No
9 empty 2.45 61.8 13.5 No No
10 empty 2.28 50.7 11.4 No No
5L47_D Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 69.1 37.1 Yes Yes
2 bound 2.44 64.5 32.8 No No
3 empty 2.32 68.7 22 No No
4 empty .83 65.3 14.5 No No
5 empty 2.71 63.4 11.4 No No
6 empty 2.54 60.9 14.1 No No
7 empty 2.22 62.7 11.1 No No
8 empty .59 68.6 12.1 No No
9 empty .42 63.2 11.3 No No
10 empty 1.73 58.3 13.9 No No
2XQ5_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 65.4 32.9 Yes No
2 empty 2.35 66.5 29.5 No No
3 empty 1.81 71.3 14.3 No No
4 empty 2.3 71.3 21.1 No No
5 empty .8 67.8 14.7 No No
6 empty 2.28 49.1 15.6 No No
7 empty 2.45 65 12.5 No No
8 empty 2.63 67.8 9.3 No No
9 empty 2.15 59.4 14 No No
10 empty .48 64.5 11.5 No No
6HYV_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 69 35.9 Yes Yes
2 bound 2.21 66.2 22.4 No No
3 bound 1.87 63.3 32.8 No No
4 empty 1.87 76.1 10.8 No No
5 empty 2.26 68.9 19.5 No No
6 empty 2.53 59.5 14.4 No No
7 empty 2.32 58.6 14.4 No No
8 bound 1.84 55.9 15.3 No No
9 empty 2.61 65.4 10.1 No No
10 empty 1.7 55.2 12.9 No No
4LML_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 67.3 33.1 Yes No
2 empty 2.35 65.5 27.5 No No
3 empty 2.3 67.3 27.4 No No
4 empty 1.66 75.9 14.7 No No
5 empty 1.75 62.3 25.2 No No
6 empty 2.21 62.1 23.5 No No
7 empty 1.61 63.7 18.5 No No
8 empty 2.22 72.7 12.4 No No
9 empty 2.5 66.1 12.5 No No
10 empty 2.14 80.3 0 No No
3EAM_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 63.2 35.4 Yes No
2 empty 2.34 65.3 29.3 No No
3 bound 2.17 68.3 25.5 No No
4 empty 1.79 70.8 18.4 No No
5 empty 2.29 75 16.7 No No
6 bound .45 69.1 12.8 No No
7 empty 2.75 67.1 12.6 No No
8 empty 2.16 71.9 12.5 No No
9 empty 2.23 63.9 9.6 No No
10 empty 2.4 56.5 12.2 No No
6F0I_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 64.2 34.9 Yes No
2 bound 2.39 64.1 29.7 No No
3 empty 2.15 63 26.9 No No
4 empty 1.89 76.1 11.7 No No
5 empty 2.21 68.9 22.9 No No
6 empty 1.95 69.6 18.5 No No
7 empty 2.64 62.5 12.5 No No
8 empty 1.77 59.2 12.8 No No
9 empty 2.28 59.9 12.2 No No
10 empty 2.06 56.5 13.2 No No
2XQ3_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 64.8 32.6 Yes No
2 empty 2.2 70.7 19.5 No No
3 empty 1.79 77.5 13.2 No No
4 empty 2.33 64.8 18.6 No No
5 empty 2.41 54.2 23.1 No No
6 empty 1.15 62.9 21.9 No No
7 empty 2.44 62 15.9 No No
8 empty 2.46 58.2 14.7 No No
9 empty 2.69 69 9.1 No No
10 empty .37 67.2 8.6 No No
5NKJ_B Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.99 68.8 33.8 Yes Yes
2 empty 2.43 65.2 29.2 No No
3 empty 2.21 63.6 25.1 No No
4 empty 1.98 67.9 19 No No
5 empty 2.23 58.8 24.6 No No
6 empty 2.3 63.3 16.8 No No
7 empty .56 66.7 16.2 No No
8 empty 1.81 59.6 15 No No
9 empty 2.74 68.7 11.5 No No
10 empty 1.93 61 13.7 No No
4LMJ_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 66.1 40.1 Yes No
2 empty 2.27 65.7 24.6 No No
3 empty 2.21 72.5 20.1 No No
4 empty .85 68.3 14.2 No No
5 empty 2.49 62 12.7 No No
6 empty 2.5 66.8 10.1 No No
7 empty 2.47 59 13.4 No No
8 empty 2.39 52.6 14.3 No No
9 empty 2.35 62.7 12 No No
10 empty 2.16 49.2 9.4 No No
6HZW_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.08 64.8 39.2 Yes No
2 bound 2.48 64.3 28.3 No No
3 empty 1.95 73.9 11.7 No No
4 empty 2.11 71.1 15.8 No No
5 empty 2.65 61.3 17.9 No No
6 empty 2.09 68.3 16.2 No No
7 empty 2.49 61 15.7 No No
8 empty 2.61 62.1 11.8 No No
9 bound 2 59 15.7 No No
10 empty .28 63.3 12 No No
4IL9_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.21 67.1 27.9 Yes No
2 empty 1.82 63.2 38.9 No No
3 bound 2.17 62.2 27.6 No No
4 empty 1.83 70 17.4 No No
5 empty 2.41 64.7 11.8 No No
6 bound .69 68.5 17.6 No No
7 empty 2.06 71.2 15 No No
8 empty 2.44 61.8 15.9 No No
9 empty 2.61 56.5 16.6 No No
10 empty 2.65 67.2 10.8 No No
2XQ7_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 64.2 37.5 Yes No
2 empty 2.34 67.3 29.6 No No
3 empty 2.46 64.2 31 No No
4 empty 1.82 77.7 13.3 No No
5 empty 2.65 69 11.7 No No
6 empty 2.04 71.6 12.4 No No
7 empty .48 67.8 11.7 No No
8 empty 2.17 62.8 11.2 No No
9 empty 2.19 65.5 13 No No
10 empty 2.46 66.5 6.6 No No
3IGQ_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 62.9 30.1 Yes No
2 empty 2.13 70.7 19 No No
3 empty 2.02 64.2 18.1 No No
4 empty 2.04 71.3 14.8 No No
5 empty 2.57 56.7 24.3 No No
6 empty 2.53 53.3 10.2 No No
7 empty 2.98 71.1 8.8 No No
8 empty 2.28 64.5 7.8 No No
9 empty 2.54 56 10.8 No No
10 empty 2.12 77.9 7.8 No No
4HFH_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.41 65.6 30.1 Yes No
2 bound 1.88 63.2 36.5 No No
3 bound 2.12 66.8 26.1 No No
4 empty 2.28 70.5 25.2 No No
5 empty 1.77 77.2 12.3 No No
6 bound .75 75.9 18.7 No No
7 empty 2.44 59.1 14.5 No No
8 empty 2.7 68.5 10.6 No No
9 bound 2.02 58.4 13.6 No No
10 empty 2.23 62 12.8 No No
6F0V_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 62.8 39.3 Yes No
2 bound 2.31 63.7 25.7 No No
3 empty 2.13 64 27 No No
4 empty 1.8 70.7 15.6 No No
5 empty 2.23 65.9 16.6 No No
6 empty 2.48 58.3 17.3 No No
7 empty .74 62.2 16.2 No No
8 empty 1.81 58.2 11.4 No No
9 empty 1.99 58 13.6 No No
10 empty 2.63 65.5 9.6 No No
5MUO_E Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 67.7 37 Yes Yes
2 bound 2.22 65.6 26 No No
3 empty 2.1 66.7 15.9 No No
4 empty 2.41 61.4 16.9 No No
5 empty 1.77 69.5 14.6 No No
6 empty 2.26 66.2 14.5 No No
7 empty .51 66.1 18.8 No No
8 empty 2.69 76.6 8.8 No No
9 empty 2.32 61.7 11.2 No No
10 empty 2.53 51.2 9.9 No No
6F0N_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 63.9 39.8 Yes No
2 bound 2.17 66.2 21.4 No No
3 empty 1.78 68.8 18.1 No No
4 bound 1.43 68.7 20 No No
5 empty 1.8 70.1 11.4 No No
6 empty 2.4 59.6 15 No No
7 empty 2.06 76.1 13.5 No No
8 empty 2.48 67.6 10.6 No No
9 empty 2.31 56.3 11.4 No No
10 bound 2 59.7 13.6 No No
6F0M_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 64.2 44.7 Yes No
2 bound 2.47 67.5 28.1 No No
3 empty 1.68 67.9 19.4 No No
4 empty 2.3 67.6 13.2 No No
5 empty 2.09 73.9 14.6 No No
6 empty 2.59 68.5 11.2 No No
7 empty 2.29 58.6 13.9 No No
8 empty 1.95 62.6 13.8 No No
9 empty 1.68 57.8 15.3 No No
10 empty 2.26 66.5 7.7 No No
2XQ6_D Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 68.4 22.1 No No
2 empty 1.94 63.8 29.3 No No
3 empty 2.16 66.7 23.2 No No
4 empty 1.76 73.9 14.3 No No
5 empty 2.32 69.7 19.2 No No
6 empty .78 70.7 16.2 No No
7 empty 2.16 45.7 17.2 No No
8 empty 2.45 65.5 14.8 No No
9 empty 2.39 60.1 14.3 No No
10 empty 2.69 65.3 9.5 No No
4IRE_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.34 65.3 30.4 Yes No
2 bound 1.99 62.6 44.4 No No
3 empty 2.13 65.8 26.4 No No
4 empty 1.8 70.7 15.1 No No
5 empty 2.02 60.3 25 No No
6 bound .82 61.2 17.3 No No
7 empty 2.17 57.6 13.9 No No
8 empty 2.3 70.5 13.5 No No
9 empty 2.71 75 10.4 No No
10 bound 2.1 60.4 15.1 No No
3LSV_E Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 63.3 41.2 Yes No
2 empty 2.28 67.1 33.7 No No
3 empty 2.14 66.6 25.8 No No
4 empty 1.82 73 15.3 No No
5 empty 2.31 72.1 14.6 No No
6 empty 2.29 65.1 20.8 No No
7 empty 2.67 69.1 10 No No
8 empty 2.28 65.1 12.4 No No
9 empty 2.31 57.2 11.4 No No
10 empty 1.81 58.1 11.2 No No
3EI0_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 63.5 37.6 Yes No
2 empty 2.43 63.2 35 No No
3 empty 1.71 76.5 15 No No
4 empty 2.35 73.4 19.3 No No
5 empty .87 69.5 16 No No
6 empty 2.57 59.6 10.9 No No
7 empty .32 66.6 13.6 No No
8 empty 2.31 52.8 13.5 No No
9 empty 1.93 73.3 10.6 No No
10 empty 2.68 66.9 12.7 No No
3UU3_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 67.9 30.7 Yes No
2 empty 2.46 64.2 29.1 No No
3 empty 2.01 69.1 17.1 No No
4 empty 2.13 66.3 25.3 No No
5 empty 2.1 64.1 19.1 No No
6 empty 2.19 72.4 17.7 No No
7 empty 1.02 66.6 17.3 No No
8 empty 2.92 69.4 11.2 No No
9 empty 2.46 62.1 12.3 No No
10 empty 2.13 62.1 12.2 No No
6F0R_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.41 66.8 30.1 Yes No
2 bound 1.78 63.2 40.7 No No
3 empty 2.14 64 26.7 No No
4 empty 1.77 69.2 19.5 No No
5 empty 2.33 69 16.2 No No
6 bound .72 69.7 14.2 No No
7 empty 2.51 63.2 14.1 No No
8 empty 2.03 70.9 11.5 No No
9 empty 2.23 52.9 11.9 No No
10 bound 1.98 57.7 15.2 No No
4YEU_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.76 66.6 24.7 Yes No
2 empty 1.92 62.1 23.3 No No
3 empty 2.04 75.9 15.7 No No
4 empty 2.19 66.1 18.1 No No
5 empty 2.1 62.4 20.6 No No
6 empty .78 70.2 17.1 No No
7 empty 2.01 64.6 16.5 No No
8 empty 2.71 66.9 21.8 No No
9 empty 2.44 56.8 13.1 No No
10 empty 2.5 63.3 19.6 No No
5IUX_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.42 68.1 30.5 Yes No
2 empty 1.82 69.1 17.4 No No
3 bound 2.2 62.4 26 No No
4 bound 2.26 61.1 26.9 No No
5 bound 1.48 64.4 19.5 No No
6 empty 1.95 74.7 13.1 No No
7 bound .67 63.5 11.4 No No
8 empty 2.04 69.8 12.9 No No
9 bound 2 59.6 14.1 No No
10 empty 2.38 65.3 7.5 No No
4NPQ_T Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 75.7 44.8 Yes Yes
2 empty 1.85 62.7 31.3 No No
3 empty 1.81 82.8 19 No No
4 empty .96 68.6 21.5 No No
5 empty 1.77 73.1 15.1 No No
6 empty 1.45 62.6 17.4 No No
7 empty 1.08 66.1 13.8 No No
8 empty 2.04 56.9 18.9 No No
9 empty .36 65.9 12.1 No No
10 empty 1.92 67.6 10.3 No No
2XQ8_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 65.1 29.4 Yes No
2 empty 1.93 64.7 28.5 No No
3 empty 2.31 66.1 27.7 No No
4 empty 2.31 71 21.9 No No
5 empty 1.77 75.7 13.4 No No
6 empty 1.12 68.8 20.9 No No
7 empty 2.39 53.4 26.5 No No
8 empty 2.49 63.8 12.7 No No
9 empty 2.42 64 11.6 No No
10 empty 2.02 72.8 7.4 No No
5V6O_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 64.4 35.6 Yes No
2 empty 2.39 66.8 29.6 No No
3 empty 2.37 66 26.6 No No
4 empty 1.83 76.7 12.6 No No
5 empty .94 65.4 15.5 No No
6 empty 2.53 59.3 20.8 No No
7 empty 1.95 70.9 13.9 No No
8 empty 2.8 71.7 10.9 No No
9 empty 1.86 67.1 8.7 No No
10 empty .24 68.8 9.8 No No
4X5T_D Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.34 69 45.1 Yes Yes
2 bound 2.06 66.9 27.5 No No
3 empty 1.66 67.6 23.1 No No
4 empty 2.35 65.8 18.6 No No
5 empty 2.02 64.3 17.4 No No
6 empty 2.26 72.4 15.7 No No
7 empty 2.25 59 14.7 No No
8 empty 2.57 62 11.1 No No
9 empty 2.26 62.9 9.7 No No
10 empty 2.49 57.6 12.2 No No
5V6N_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 65 40.1 Yes No
2 empty 2.47 64.2 33 No No
3 empty 1.69 65.6 20.9 No No
4 empty 2.3 66.5 15.9 No No
5 empty .6 69.7 18.7 No No
6 empty 2.14 54.5 18.3 No No
7 empty 1.89 81.8 10.7 No No
8 empty 2.85 68 10.5 No No
9 empty 2.1 60.7 15.2 No No
10 empty 2.19 66.5 13 No No
6HJI_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.42 64.9 30 Yes No
2 bound 1.88 64.1 44.5 No No
3 empty 2.1 64.5 26.9 No No
4 empty 1.81 69.2 17.9 No No
5 empty 2.17 74.4 20 No No
6 bound .72 74.2 14.5 No No
7 empty 2.76 69.7 11.5 No No
8 empty 2.42 67.3 7.4 No No
9 empty 2.43 62.8 10.2 No No
10 empty 2.06 64.4 14.6 No No
6HJZ_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 62.8 41.5 Yes No
2 bound 2.26 67.9 27.7 No No
3 empty 2.14 64.2 26.7 No No
4 empty 1.81 64.1 21.2 No No
5 bound .98 73.6 16.6 No No
6 empty 2.36 67.4 18.2 No No
7 empty 1.99 76.7 15.1 No No
8 empty 2.62 70.8 11.3 No No
9 bound 2.02 58.4 14.3 No No
10 empty 2.4 64.9 10.4 No No
5MVM_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 67.7 29.5 Yes Yes
2 empty 1.89 65.3 25.1 No No
3 bound 2.19 66 22.4 No No
4 empty 1.78 66.3 17.5 No No
5 empty 2.39 70.5 17.5 No No
6 empty 2.34 58.1 14.7 No No
7 empty 2.74 64.4 11 No No
8 empty 2.36 60.3 10.6 No No
9 empty 2.1 56.6 13.5 No No
10 empty 2.25 62.4 12.1 No No
5L4E_B Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 70.2 35.7 Yes Yes
2 empty 2.41 65.1 33.2 No No
3 empty 2.25 58 24.1 No No
4 empty .66 70.6 13 No No
5 empty 2.25 70.9 17.2 No No
6 empty .65 66.8 18.2 No No
7 empty 2.04 66.8 15 No No
8 empty 2.63 63.5 11.8 No No
9 empty 2.46 63.9 15.3 No No
10 empty 2.22 62.2 10.7 No No
5MZQ_C Proton-gated ion channel Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 68 39.3 Yes Yes
2 empty 1.95 65.1 24.9 No No
3 bound 2.19 66.5 19.6 No No
4 empty 1.76 71.7 17.8 No No
5 empty 2.05 75.8 13 No No
6 empty 2.42 59.3 13.9 No No
7 empty 2.64 66.4 12 No No
8 empty 2.16 72.3 11.3 No No
9 bound 2.05 56 13.6 No No
10 empty 2.52 59.6 13.3 No No
5OSB_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 65.6 29.9 Yes No
2 empty 2.09 67.7 20.2 No No
3 empty 2.19 68.9 17.2 No No
4 empty 2.23 62 15 No No
5 empty 2.14 61 17.8 No No
6 empty 2.74 72.1 9.8 No No
7 empty 2.21 61.3 10.3 No No
8 empty 2.24 60.7 12.7 No No
9 empty 2.58 56.3 16.2 No No
10 bound 2.04 56.3 12.5 No No
6F16_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.38 65.1 30.3 Yes No
2 bound 1.92 63.8 32.3 No No
3 empty 2.11 64.4 26.7 No No
4 empty 2.25 71.8 26.9 No No
5 empty 1.86 73.4 14.9 No No
6 bound .73 70.1 14.6 No No
7 empty 2.51 64.9 12.9 No No
8 empty 2.33 53.5 12.1 No No
9 empty 1.61 62.5 10.9 No No
10 empty 2 56.4 13.6 No No
4HFD_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 64.7 42.1 Yes No
2 bound 2.1 66.8 21.8 No No
3 empty 1.9 74.8 12.6 No No
4 bound .84 76.3 17.8 No No
5 empty 2.51 65.7 18.4 No No
6 empty 2.25 70.8 18.3 No No
7 empty 2.36 58.1 14.1 No No
8 empty 2.49 62.8 12.5 No No
9 empty 2.39 60.4 11.7 No No
10 bound 2.01 55.8 14.9 No No
2XQ5_A Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 64.6 30.1 Yes No
2 empty 2.14 62.9 27 No No
3 empty 2.19 64.9 23.4 No No
4 empty 1.77 76.7 12 No No
5 empty 2.36 70.7 15.6 No No
6 empty 2.29 47.3 22.6 No No
7 empty .81 67 15 No No
8 empty 2.46 61.8 11.5 No No
9 empty 2.72 65.9 11.8 No No
10 empty .31 63.5 11 No No
3TLU_C Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 65.8 31.5 Yes No
2 empty 2.41 64.4 29.9 No No
3 empty 2.14 62.8 24.4 No No
4 empty 2.35 71.8 25.1 No No
5 empty .98 67 19.6 No No
6 empty 2.63 65.2 9.8 No No
7 empty 2.29 60.4 10.6 No No
8 empty .41 70.4 8.9 No No
9 empty 2.5 57.8 11.7 No No
10 empty .53 71 9.8 No No
2XQA_B Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 66.6 22.5 No No
2 empty 2.01 63.5 30.2 No No
3 empty 2.24 64.3 24.4 No No
4 empty 1.81 74.8 13.2 No No
5 empty 2.33 68 16 No No
6 empty 1.1 64.3 15.7 No No
7 empty 2.22 49.8 15 No No
8 empty 2.42 59.4 14.6 No No
9 empty 2.46 57 13 No No
10 empty 2.63 68.8 9.7 No No
5V6O_B Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 63.8 38.6 Yes No
2 empty 2.35 64.3 31.5 No No
3 empty 2.32 68.8 25.1 No No
4 empty 1.89 68.6 23.2 No No
5 empty .67 70.6 17.7 No No
6 empty 2.76 71.9 12.9 No No
7 empty 2.17 63 12.3 No No
8 empty 2.52 64.7 10 No No
9 empty 1.49 64.3 11.6 No No
10 empty 1.85 59.8 15.5 No No
4IL9_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 63 39.6 Yes No
2 bound 2.2 68.4 21.1 No No
3 empty 2.25 69.9 32.7 No No
4 empty 1.83 78 12.1 No No
5 bound .72 63.2 17.5 No No
6 empty 2.46 60.4 15.5 No No
7 empty 2.71 67.5 10.6 No No
8 bound 2 57.1 13.6 No No
9 empty 1.75 58.1 14.5 No No
10 empty 2.41 59.9 11.9 No No
4F8H_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 63.5 39.3 Yes No
2 empty 2.26 68.2 20.8 No No
3 empty 1.86 72.9 15.5 No No
4 empty 2.41 71.9 17.9 No No
5 empty 2.41 58 16.2 No No
6 empty 2.09 60.3 20.3 No No
7 empty 2.77 71.7 9.6 No No
8 empty 2.47 60.3 12.7 No No
9 empty 2.54 66.4 11.3 No No
10 empty 2.17 60.5 10.4 No No
3UUB_H Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 64.2 33.4 Yes No
2 empty 2.02 66.6 26.1 No No
3 bound 2.14 64.3 23.6 No No
4 empty 1.91 75.8 11 No No
5 empty 2.33 73.5 15.7 No No
6 bound .66 68.1 13.2 No No
7 empty .33 69.3 18.6 No No
8 empty 2.18 74 17.6 No No
9 empty 2.7 67.2 12.4 No No
10 empty 2.34 52.2 12.3 No No
6HY5_C Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 No No
2 No No
3 No No
4 No No
5 No No
6 No No
7 No No
8 No No
9 No No
10 No No
6HYW_E Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 No No
2 No No
3 No No
4 No No
5 No No
6 No No
7 No No
8 No No
9 No No
10 No No
2XQ3_D Proton-gated ion channel Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 67.1 28.3 Yes No
2 empty 2.19 67.9 24.5 No No
3 empty 2.19 63.8 27 No No
4 empty 1.78 72.2 12.2 No No
5 empty 2.28 69.7 19.1 No No
6 empty 1.19 65.2 26.1 No No
7 empty 2.25 48.6 15.4 No No
8 empty 2.49 65.5 9.3 No No
9 empty 2.6 72.1 9 No No
10 empty .5 66.4 11.3 No No
3IGQ_F Proton-gated ion channel No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 69.6 17.3 No No
2 empty 2.57 60.6 22.7 No No
3 empty 2.11 68 18.1 No No
4 empty 2.55 56.3 24.6