Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

glvI (Q7NDN8) - Overview - Molecular Target Synopsis

Protein


glvI, Proton-gated ion channel
UniProt Q7NDN8

Also Known as GLIC_GLOVI, glvI

Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change. Homopentamer.

6HYR
THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Q193C+MMTS
RCSB/PDB
Inspect Structure
See all 3D Structures for glvI

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
359Q7NDN8-1

Sub-cellular localization


UniProt: glvI is active in the following subcellular-locations: cell inner membrane.
GO terms: glvI is active in the following subcellular-locations: integral component of plasma membrane, neuron projection, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project glvI has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For glvI there are:
103 structures (536 chains) solved
78 are solved in complex with at least one small molecule ligand
6 are solved with an approved drug

glvI is solved in complex with the approved drug(s):

PFL/PROPOFOL (3P50_A, 3P50_B, 3P50_C, 3P50_D, 3P50_E, 5MUO_D, 5MUR_B, 5MUR_E, 5MVM_A, 5MVM_B, 5MVM_C, 5MVM_E, 5MVN_B, 5MVN_C, 5MVN_D, 5MVN_E, 5MZR_A, 5MZR_C, 5MZR_D, 5MZR_E).

(see details)
Molecular Target 3D Synopsis