TAOK1 (Q7L7X3) - Overview - Molecular Target Synopsis
TAOK1, Serine/threonine-protein kinase TAO1
Enzyme Classification 188.8.131.52
Also Known as TAOK1_HUMAN, TAOK1, KIAA1361, MAP3K16, MARKK
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Self-associates. Interacts with MAP2K3 (By similarity). Interacts with SPRED1 and TESK1. Interacts with MAP3K7.
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UniProt: TAOK1 is active in the following subcellular-locations: cytoplasm.
GO terms: TAOK1 is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome, microtubule cytoskeleton, nucleus, perinuclear region of cytoplasm.