Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SV2B (Q7L1I2) - Overview - Molecular Target Synopsis

Protein


SV2B, Synaptic vesicle glycoprotein 2B
UniProt Q7L1I2

Also Known as SV2B_HUMAN, SV2B, KIAA0735

Probably plays a role in the control of regulated secretion in neural and endocrine cells., (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25.

Isoforms / Transcripts (Protein Coding)


Drugs


SV2B is targeted by Approved Drug Onabotulinumtoxina. (see details)
Onabotulinumtoxina

Sub-cellular localization


UniProt: SV2B is active in the following subcellular-locations: acrosome, cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane.
GO terms: SV2B is active in the following subcellular-locations: acrosomal vesicle, cell junction, integral component of membrane, membrane, neuron projection, plasma membrane, synaptic vesicle, synaptic vesicle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SV2B has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, CAKI_1, 786_0

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 454, DMS 53, NCI-H146

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to SV2B there are:
2 structures (3 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SV2B has been screened with compounds ( bioactivities). (see details)