Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RHOU (Q7L0Q8) - Overview - Molecular Target Synopsis

Protein


RHOU, Rho-related GTP-binding protein RhoU
UniProt Q7L0Q8

Also Known as RHOU_HUMAN, RHOU, ARHU, CDC42L1, G28K, WRCH1

Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Interacts with PAK3. Interacts with ARHGAP30 in a GTP-independent manner. In its GTP-loaded conformation, interacts with ARHGAP31. Interacts with PTK2B/PYK2.

2Q3H
THE CRYSTAL STRUCTURE OF RHOUA IN THE GDP-BOUND STATE.
RCSB/PDB
Inspect Structure
See all 3D Structures for RHOU

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
258ENSG00000116574ENST00000366691ENSP00000355652Q7L0Q8-1
197Q7L0Q8-2

Sub-cellular localization


UniProt: RHOU is active in the following subcellular-locations: cell junction, cell membrane, cell projection, focal adhesion, golgi apparatus membrane, podosome.
GO terms: RHOU is active in the following subcellular-locations: cell cortex, cell projection, cytoplasm, cytosol, focal adhesion, Golgi membrane, plasma membrane, podosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RHOU has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MOLT_4, HL_60, HCC_2998

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OUMS-23, SW 1417, RT4

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, SK-N-SH, NHLF

(see details)

3D Structures


For RHOU there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RHOU has been screened with compounds ( bioactivities). (see details)