Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
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Chemistry
Ligand Efficiency Plot
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higB (Q7A225) - Overview - Molecular Target Synopsis

Protein


higB, Endoribonuclease HigB
Enzyme Classification 3.1.-.-
UniProt Q7A225

Also Known as HIGB_PROVU, higB

Toxic component of a type II toxin-antitoxin (TA) system (PubMed:19423702, PubMed:24257752, PubMed:8645296). A ribosome-associated translation-dependent mRNA interferase. Inhibits translation by sequence-specific cleavage of mRNA. Prefers either in-frame or out-of-frame 5'-AAA-3' codons (lysine). Cleaves also the first three AAAs of stretches of four or more A sequences. 20% of codons containing AA are cleaved and occassionally cuts even at a single A (PubMed:19423702). Forms a complex with the antitoxin HigA which inhibits the mRNA interferase activity (PubMed:19423702). The heterodimer dimerizes to form a HigB-(HigA)2-HigB tetramer that is able to bind to the DNA (PubMed:24257752).

5IWH
STRUCTURE OF P. VULGARIS HIGB TOXIN DELTA H92
RCSB/PDB
Inspect Structure
See all 3D Structures for higB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
92Q7A225-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project higB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For higB there are:
6 structures (16 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis