Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

kaiC (Q79PF4) - Overview - Molecular Target Synopsis

Protein


kaiC, Circadian clock protein kinase KaiC
Enzyme Classification 2.7.11.1
UniProt Q79PF4

Also Known as KAIC_SYNE7, kaiC

Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. Homohexamer; hexamerization is dependent on ATP-binding. Core component of the KaiABC complex, at least composed of a KaiC homohexamer, a KaiB dimer and two KaiA dimers. Interacts directly with SasA.

5YZ8
CRYSTAL STRUCTURE OF N-TERMINAL C1 DOMAIN OF KAIC
RCSB/PDB
Inspect Structure
See all 3D Structures for kaiC

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
519Q79PF4-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project kaiC has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For kaiC there are:
25 structures (143 chains) solved
23 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis