Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ERN2 (Q76MJ5) - Overview - Molecular Target Synopsis

Protein


ERN2, Serine/threonine-protein kinase/endoribonuclease IRE2
Enzyme Classification 2.7.11.1
UniProt Q76MJ5

Also Known as ERN2_HUMAN, ERN2, IRE2

Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ERN2 is active in the following subcellular-locations: endoplasmic reticulum membrane.
GO terms: ERN2 is active in the following subcellular-locations: endoplasmic reticulum membrane, integral component of membrane, IRE1-TRAF2-ASK1 complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ERN2 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, COLO205, HCC_2998

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCUM-1, HCC4006, HCC1263

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


ERN2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: OE19, MDAMB436. (see details)

3D Structures


At greater than 50% identity similarity to ERN2 there are:
13 structures (30 chains) solved
11 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ERN2 has been screened with compounds ( bioactivities). (see details)