Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

fosB (Q739M9) - Overview - Molecular Target Synopsis

Protein


fosB, Metallothiol transferase FosB
Enzyme Classification 2.5.1.-
UniProt Q739M9

Also Known as FOSB_BACC1, fosB

Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. Homodimer.

4JH1
CRYSTAL STRUCTURE OF FOSB FROM BACILLUS CEREUS WITH ZINC AND SULFATE AT 1.55 A RESOLUTION -SAD PHASING
RCSB/PDB
Inspect Structure
See all 3D Structures for fosB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
138Q739M9-1

Sub-cellular localization


UniProt: fosB is active in the following subcellular-locations: cytoplasm.
GO terms: fosB is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project fosB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For fosB there are:
9 structures (18 chains) solved
7 are solved in complex with at least one small molecule ligand
5 are solved with an approved drug

fosB is solved in complex with the approved drug(s):

FCN/FOSFOMYCIN (4JH3_A, 4JH3_B, 4JH4_A, 4JH4_B, 4JH5_A, 4JH5_B, 4JH6_A, 4JH6_B, 4JH8_A, 4JH8_B),
CYS/CYSTEINE (4JH8_A, 4JH8_B).

(see details)
Molecular Target 3D Synopsis