Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

NEK10 (Q6ZWH5) - Overview - Molecular Target Synopsis


NEK10, Serine/threonine-protein kinase Nek10
Enzyme Classification
UniProt Q6ZWH5

Also Known as NEK10_HUMAN, NEK10

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: NEK10 is active in the following subcellular-locations: protein kinase complex.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project NEK10 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: KM12, HT29, NCI_ADR_RES

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, Hs 746T, NCI-H322T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference

NEK10 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: 93VU, HUO3N1. (see details)

3D Structures

At greater than 35% identity similarity to NEK10 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

NEK10 has been screened with 1 compounds (1 bioactivities). (see details)