Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NEK10 (Q6ZWH5) - Overview - Molecular Target Synopsis

Protein


NEK10, Serine/threonine-protein kinase Nek10
Enzyme Classification 2.7.11.1
UniProt Q6ZWH5

Also Known as NEK10_HUMAN, NEK10

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: NEK10 is active in the following subcellular-locations: protein kinase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NEK10 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, HT29, NCI_ADR_RES

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, Hs 746T, NCI-H322T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


NEK10 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: 93VU, HUO3N1. (see details)

3D Structures


At greater than 35% identity similarity to NEK10 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


NEK10 has been screened with 1 compounds (1 bioactivities). (see details)