Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DENND5B (Q6ZUT9) - Overview - Molecular Target Synopsis

Protein


DENND5B, DENN domain-containing protein 5B
UniProt Q6ZUT9

Also Known as DEN5B_HUMAN, DENND5B

Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: DENND5B is active in the following subcellular-locations: membrane.
GO terms: DENND5B is active in the following subcellular-locations: cytosol, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DENND5B has gain in 16 cell-lines, loss in 2 cell-lines and no signal in 986 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, OVCAR_8, IGROV1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO 699, SNU-475, SW 900

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 50% identity similarity to DENND5B there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis