Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RFLNA (Q6ZTI6) - Overview - Molecular Target Synopsis

Protein


RFLNA, Refilin-A
UniProt Q6ZTI6

Also Known as RFLA_HUMAN, RFLNA, FAM101A

Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells. Interacts with FLNA and FLNB.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RFLNA is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: RFLNA is active in the following subcellular-locations: actin filament bundle, cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RFLNA has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)