Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TMPPE (Q6ZT21) - Overview - Molecular Target Synopsis

Protein


TMPPE, Transmembrane protein with metallophosphoesterase domain
Enzyme Classification 3.1.-.-
UniProt Q6ZT21

Also Known as TMPPE_HUMAN, TMPPE

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
489ENSG00000188167ENST00000342462ENSP00000343398
453Q6ZT21-1
323ENSG00000188167ENST00000416695ENSP00000400715
316Q6ZT21-2

Sub-cellular localization


UniProt: TMPPE is active in the following subcellular-locations: membrane.
GO terms: TMPPE is active in the following subcellular-locations: integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TMPPE has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, HCC12, DMS 53

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH_RA, SK-N-SH

(see details)