Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RNF165 (Q6ZSG1) - Overview - Molecular Target Synopsis

Protein


RNF165, E3 ubiquitin-protein ligase RNF165
Enzyme Classification 2.3.2.27
UniProt Q6ZSG1

Also Known as RN165_HUMAN, RNF165

E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. Monomer; binding to the ubiquitin-conjugating enzyme E2 does not trigger homodimerization (PubMed:26656854).

5ULH
STRUCTURE OF RNF165 IN COMPLEX WITH A UBCH5B~UB CONJUGATE
RCSB/PDB
Inspect Structure
See all 3D Structures for RNF165

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RNF165 is active in the following subcellular-locations: nucleus.
GO terms: RNF165 is active in the following subcellular-locations: nucleus, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RNF165 has gain in 2 cell-lines, loss in 8 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, HL_60, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MHH-NB-11, NCI-H847, SK-N-FI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For RNF165 there are:
5 structures (9 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis