Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RGS9BP (Q6ZS82) - Overview - Molecular Target Synopsis

Protein


RGS9BP, Regulator of G-protein signaling 9-binding protein
UniProt Q6ZS82

Also Known as R9BP_HUMAN, RGS9BP, R9AP

Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation. Specifically interacts with isoform RGS9-1 of RGS9. Component of the RGS9-1-Gbeta5 complex composed of RGS9-1, Gbeta5 (GNB5) and RGS9BP.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
517ENSG00000186326ENST00000334176ENSP00000334134
235Q6ZS82-1

Sub-cellular localization


UniProt: RGS9BP is active in the following subcellular-locations: membrane.
GO terms: RGS9BP is active in the following subcellular-locations: integral component of membrane, photoreceptor outer segment.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RGS9BP has gain in 11 cell-lines, loss in 2 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1599, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)