Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FRRS1 (Q6ZNA5) - Overview - Molecular Target Synopsis

Protein


FRRS1, Ferric-chelate reductase 1
Enzyme Classification 1.-.-.-
UniProt Q6ZNA5

Also Known as FRRS1_HUMAN, FRRS1, SDFR2, SDR2

Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
626ENSG00000156869ENST00000287474ENSP00000287474Q6ZNA5-2
592ENSG00000156869ENST00000414213ENSP00000393884Q6ZNA5-1

Sub-cellular localization


UniProt: FRRS1 is active in the following subcellular-locations: membrane.
GO terms: FRRS1 is active in the following subcellular-locations: integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FRRS1 has gain in 6 cell-lines, loss in 2 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_62, U251, SNB_19

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCUM-1, HEL, SCC-25

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH_RA, GM12878

(see details)