Molecular Target Synopsis
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Domains and Structures
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MAP3K15 (Q6ZN16) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - HUMAN 4LG4_A 35.16 1.0E-33 2.415Å - 2013-09-18
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - 4BF2_A 82.87 0 2.11Å STU 2013-07-03
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 6E2M_B 82.19 0 2.25Å KK7 2018-09-19
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5V19_B 86.25 0 3.1Å 8V4 2017-03-29
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4QMS_A 37.07 5.0E-33 1.88Å 1N1 2015-07-01
Protein kinase domain (99%) (view alignment) STK26 (Q9P289) CAB39 (Q9Y376) HUMAN 4FZD_B 35.8 8.0E-33 3.25Å - 2013-03-06
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 4BIC_A 82.87 0 2.62Å IE4 2013-07-03
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 6E2N_B 82.19 0 2.1Å KK8 2018-09-19
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5VIO_C 83.22 0 2.84Å - 2018-01-17
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - HUMAN 4LG4_C 35.16 1.0E-33 2.415Å - 2013-09-18
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - HUMAN 4LG4_F 35.16 1.0E-33 2.415Å - 2013-09-18
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 3A7F_A 37.07 4.0E-33 1.55Å - 2010-02-02
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) CAB39 (Q9Y376) HUMAN 4O27_B 36.68 2.0E-32 3.185Å ADP 2014-12-03
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4QMM_A 37.07 5.0E-33 1.85Å 35R 2015-07-01
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5VIL_C 83.22 0 2.64Å 9E1 2018-01-17
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 2CLQ_B 83.22 0 2.3Å STU 2006-05-09
Protein kinase domain (99%) (view alignment) STK25 (O00506) CAB39 (Q9Y376) HUMAN 4NZW_B 35.8 4.0E-32 3.58Å J60 2014-12-03
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5UP3_B 86.25 0 2.95Å 8GS 2017-06-07
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4QMN_A 37.07 5.0E-33 2.09Å DB8 2015-07-01
Protein kinase domain (99%) (view alignment) STK3 (Q13188) SAV1 (Q9H4B6) HUMAN 6AO5_A 35.8 4.0E-34 2.95Å ANP 2017-11-08
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4QMU_A 37.07 5.0E-33 1.55Å SKE 2015-07-01
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - 3A7G_B 37.07 4.0E-33 2Å - 2010-02-02
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 4BID_A 82.87 0 2.8Å IE8 2013-07-03
Protein kinase domain (99%) (view alignment) PAK1 (Q13153) - HUMAN 4ZJI_A 35.29 1.0E-34 1.99Å 4OQ 2015-06-24
Protein kinase domain (99%) (view alignment) STK26 (Q9P289) - HUMAN 3GGF_B 36.19 1.0E-33 2.35Å GVD 2009-03-24
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - HUMAN 5DH3_B 35.55 3.0E-34 2.45Å 5BS 2016-08-31
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 6E2M_A 82.19 0 2.25Å KK7 2018-09-19
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4QO9_B 37.07 5.0E-33 2.2Å 627 PGE 2015-07-29
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - HUMAN 4LG4_D 35.16 1.0E-33 2.415Å - 2013-09-18
Protein kinase domain (99%) (view alignment) STK3 (Q13188) RASSF5 (Q8WWW0) HUMAN 4LGD_B 35.8 4.0E-34 3.05Å ANP 2013-09-18
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - 3A7H_A 37.07 4.0E-33 1.96Å ATP 2010-02-02
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4QMV_A 37.07 5.0E-33 2.4Å 34W 2015-07-01
Protein kinase domain (99%) (view alignment) STK3 (Q13188) RASSF5 (Q8WWW0) HUMAN 4LGD_A 35.8 4.0E-34 3.05Å ANP 2013-09-18
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5V24_B 86.25 0 2.5Å 8V7 2017-03-29
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - 4BF2_B 82.87 0 2.11Å STU 2013-07-03
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 6E2O_A 82.19 0 2.25Å S0L 2018-09-19
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) CAB39L (Q9H9S4) HUMAN 3ZHP_C 37.07 5.0E-33 2.9Å - 2013-01-16
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 3CKW_A 37.07 4.0E-33 1.96Å - 2008-04-29
Protein kinase domain (99%) (view alignment) STK3 (Q13188) RASSF5 (Q8WWW0) HUMAN 4LGD_C 35.8 4.0E-34 3.05Å ANP 2013-09-18
Protein kinase domain (99%) (view alignment) STK26 (Q9P289) CAB39 (Q9Y376) HUMAN 4FZA_B 35.8 8.0E-33 3.15Å - 2013-03-06
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - HUMAN 4LG4_E 35.16 1.0E-33 2.415Å - 2013-09-18
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) CAB39L (Q9H9S4) HUMAN 3ZHP_D 37.07 5.0E-33 2.9Å - 2013-01-16
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5VIL_B 83.22 0 2.64Å 9E1 2018-01-17
Protein kinase domain (99%) (view alignment) STK25 (O00506) - HUMAN 2XIK_A 36.19 4.0E-33 1.97Å J60 2010-07-14
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 4BID_B 82.87 0 2.8Å IE8 2013-07-03
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4QMY_A 37.07 5.0E-33 1.88Å STU 2015-07-01
Protein kinase domain (99%) (view alignment) PAK1 (Q13153) - HUMAN 4ZJI_D 35.29 1.0E-34 1.99Å 4OQ 2015-06-24
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5VIL_A 83.22 0 2.64Å 9E1 2018-01-17
Domain of unknown function (DUF4071) (73%) (view alignment) MAP3K5 (Q99683) - HUMAN 5ULM_A 60.41 0 2.1Å - 2017-03-01
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4QMZ_A 37.07 5.0E-33 1.88Å B49 2015-07-01
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 3VW6_A 86.25 0 2.4Å IM6 2012-10-31
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5UP3_A 86.25 0 2.95Å 8GS 2017-06-07
Protein kinase domain (99%) (view alignment) STK3 (Q13188) RASSF5 (Q8WWW0) HUMAN 4LGD_D 35.8 4.0E-34 3.05Å ANP 2013-09-18
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4W8D_A 37.07 5.0E-33 1.77Å 3JA 2015-03-18
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 2CLQ_A 83.22 0 2.3Å STU 2006-05-09
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - HUMAN 5DH3_A 35.55 3.0E-34 2.45Å 5BS 2016-08-31
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 3CKX_A 37.07 4.0E-33 2.7Å STU 2008-04-29
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - 3A7G_A 37.07 4.0E-33 2Å - 2010-02-02
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - 3A7H_B 37.07 4.0E-33 1.96Å ATP 2010-02-02
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4QML_A 37.07 5.0E-33 1.88Å ANP 2015-07-01
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 4BHN_A 82.87 0 2.3Å BH9 2013-07-03
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 4BIB_B 82.87 0 2.43Å IEO 2013-07-03
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 4BIB_A 82.87 0 2.43Å IEO 2013-07-03
Protein kinase domain (99%) (view alignment) STK26 (Q9P289) - HUMAN 3GGF_A 36.19 1.0E-33 2.35Å GVD 2009-03-24
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4QMT_A 37.07 5.0E-33 1.5Å H1N 2015-07-01
Protein kinase domain (99%) (view alignment) PAK1 (Q13153) - HUMAN 4ZJJ_D 35.29 1.0E-34 2.2Å 4OR 2015-06-24
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5VIO_D 83.22 0 2.84Å 9E4 2018-01-17
Protein kinase domain (99%) (view alignment) STK26 (Q9P289) CAB39 (Q9Y376) HUMAN 4FZF_B 35.8 8.0E-33 3.64Å DKI 2013-03-06
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4QMX_A 37.07 5.0E-33 1.88Å H8H 2015-07-01
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 6E2O_B 82.19 0 2.25Å S0L 2018-09-19
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5UOR_A 86.25 0 2.75Å 8GV 2017-06-07
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 4BIE_A 82.87 0 2.36Å IE6 2013-07-03
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4QMW_A 37.07 5.0E-33 1.6Å KS1 2015-07-01
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5VIO_A 83.22 0 2.84Å 9E4 2018-01-17
Protein kinase domain (99%) (view alignment) PAK1 (Q13153) - HUMAN 4ZJJ_A 35.29 1.0E-34 2.2Å 4OR 2015-06-24
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4U8Z_A 37.07 5.0E-33 1.63Å 3FE 2015-03-18
Domain of unknown function (DUF4071) (73%) (view alignment) MAP3K5 (Q99683) - HUMAN 5ULM_B 60.41 0 2.1Å - 2017-03-01
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5UOR_B 86.25 0 2.75Å 8GV 2017-06-07
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 4BIE_B 82.87 0 2.36Å IE6 2013-07-03
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 6E2N_A 82.19 0 2.1Å KK8 2018-09-19
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4QMO_A 37.07 5.0E-33 1.9Å 34L 2015-07-01
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5V19_A 86.25 0 3.1Å 8V4 2017-03-29
Protein kinase domain (99%) (view alignment) STK4 (Q13043) - HUMAN 3COM_B 36.58 5.0E-35 2.2Å - 2008-04-15
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4QO9_A 37.07 5.0E-33 2.2Å 627 PGE 2015-07-29
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - 3A7I_A 37.07 4.0E-33 1.45Å ADE 2010-02-02
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 4BIC_B 82.87 0 2.62Å - 2013-07-03
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 4BHN_B 82.87 0 2.3Å BH9 2013-07-03
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5UOX_B 86.25 0 2.5Å 8GY 2017-06-07
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4QNA_A 37.07 5.0E-33 1.85Å X11 2015-07-01
Protein kinase domain (99%) (view alignment) PAK1 (Q13153) - HUMAN 4ZJI_B 35.29 1.0E-34 1.99Å 4OQ 2015-06-24
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 3VW6_B 86.25 0 2.4Å IM6 2012-10-31
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5VIO_B 83.22 0 2.84Å 9E4 2018-01-17
Protein kinase domain (99%) (view alignment) STK4 (Q13043) - HUMAN 3COM_A 36.58 5.0E-35 2.2Å - 2008-04-15
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5UOX_A 86.25 0 2.5Å 8GY 2017-06-07
Protein kinase domain (99%) (view alignment) PAK1 (Q13153) - HUMAN 4ZLO_A 35.29 8.0E-35 2.5Å 4PV 2015-08-05
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5VIL_D 83.22 0 2.64Å 9E1 2018-01-17
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4QMP_A 37.07 5.0E-33 2Å DKI 2015-07-01
Protein kinase domain (99%) (view alignment) PAK1 (Q13153) - HUMAN 4ZJJ_B 35.29 1.0E-34 2.2Å 4OR 2015-06-24
Protein kinase domain (99%) (view alignment) PAK1 (Q13153) - HUMAN 4ZJJ_C 35.29 1.0E-34 2.2Å 4OR 2015-06-24
Protein kinase domain (100%) (view alignment) MAP3K5 (Q99683) - HUMAN 5V24_A 86.25 0 2.5Å 8V7 2017-03-29
Protein kinase domain (99%) (view alignment) PAK1 (Q13153) - HUMAN 4ZLO_B 35.29 8.0E-35 2.5Å - 2015-08-05
Protein kinase domain (99%) (view alignment) PAK1 (Q13153) - HUMAN 4ZJI_C 35.29 1.0E-34 1.99Å 4OQ 2015-06-24
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - 3A7J_A 37.07 4.0E-33 1.5Å ADP 2010-02-02
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - HUMAN 4LG4_B 35.16 1.0E-33 2.415Å - 2013-09-18
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4W8E_A 37.07 4.0E-33 1.79Å 3JB 2015-03-18
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 4QMQ_A 37.07 5.0E-33 1.77Å 34U 2015-07-01