Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAP3K15 (Q6ZN16) - Overview - Molecular Target Synopsis

Protein


MAP3K15, Mitogen-activated protein kinase kinase kinase 15
Enzyme Classification 2.7.11.25
UniProt Q6ZN16

Also Known as M3K15_HUMAN, MAP3K15, ASK3

May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.

Isoforms / Transcripts (Protein Coding)


Gene Copy Number Variation


In COSMIC - Cell Lines Project MAP3K15 has gain in 1 cell-lines, loss in 51 cell-lines and no signal in 953 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, SW_620, SNB_19

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-M2, HCC12, NCI-H1930

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


MAP3K15 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: HCH1, OVTOKO. (see details)

3D Structures


At greater than 75% identity similarity to MAP3K15 there are:
18 structures (40 chains) solved
18 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MAP3K15 has been screened with 86 compounds (92 bioactivities), 2 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)