Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AATK (Q6ZMQ8) - Overview - Molecular Target Synopsis

Protein


AATK, Serine/threonine-protein kinase LMTK1
Enzyme Classification 2.7.11.1
UniProt Q6ZMQ8

Also Known as LMTK1_HUMAN, AATK, AATYK, KIAA0641, LMR1, LMTK1

May be involved in neuronal differentiation. Interacts with CDK5.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: AATK is active in the following subcellular-locations: cytoplasm, membrane, perinuclear region.
GO terms: AATK is active in the following subcellular-locations: integral component of membrane, perinuclear region of cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AATK has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, HCC_2998, HCT_116

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MeWo, OVKATE, C2BBe1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, SK-N-SH, NHLF

(see details)

RNA Interference


AATK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: COV504, MHM. (see details)

3D Structures


At greater than 35% identity similarity to AATK there are:
19 structures (23 chains) solved
11 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


AATK has been screened with compounds ( bioactivities). (see details)