Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

DSTYK (Q6XUX3) - Overview - Molecular Target Synopsis


DSTYK, Dual serine/threonine and tyrosine protein kinase
Enzyme Classification
UniProt Q6XUX3

Also Known as DUSTY_HUMAN, DSTYK, KIAA0472, RIP5, RIPK5, SGK496

Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: DSTYK is active in the following subcellular-locations: apical cell membrane, basolateral cell membrane, cell junction, cell membrane, cytoplasm.
GO terms: DSTYK is active in the following subcellular-locations: apical plasma membrane, basolateral plasma membrane, cell junction, cytoplasm.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project DSTYK has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_5, M14, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-MEL-1, C32, COLO-783

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, BJ, AG445

(see details)

RNA Interference

DSTYK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MDAMB453, SKBR3. (see details)

3D Structures

At greater than 35% identity similarity to DSTYK there are:
5 structures (9 chains) solved
5 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

DSTYK has been screened with 81 compounds (81 bioactivities), 6 compounds have bioactivities that show binding affinity of <= 500nM (6 bioactivities). (see details)