PCSK4 (Q6UW60) - Overview - Molecular Target Synopsis
PCSK4, Proprotein convertase subtilisin/kexin type 4
Enzyme Classification 3.4.21.-
Also Known as PCSK4_HUMAN, PCSK4, PC4
Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity). In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (PubMed:16040806). May also participate in folliculogenesis in the ovaries. The proPCSK4 form interacts with HSPA5; the interaction takes place at the endoplasmic reticulum.
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UniProt: PCSK4 is active in the following subcellular-locations: acrosome membrane, cytoplasmic vesicle, membrane, secretory vesicle.
GO terms: PCSK4 is active in the following subcellular-locations: acrosomal membrane, acrosomal vesicle, integral component of Golgi membrane, membrane, trans-Golgi network.