Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

METAP1D (Q6UB28) - Overview - Molecular Target Synopsis

Protein


METAP1D, Methionine aminopeptidase 1D, mitochondrial
Enzyme Classification 3.4.11.18
UniProt Q6UB28

Also Known as MAP12_HUMAN, METAP1D, MAP1D

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
335ENSG00000172878ENST00000315796ENSP00000315152Q6UB28-1

Sub-cellular localization


UniProt: METAP1D is active in the following subcellular-locations: mitochondrion.
GO terms: METAP1D is active in the following subcellular-locations: intracellular membrane-bounded organelle, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project METAP1D has gain in 3 cell-lines, loss in 2 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: U-937, NCI-H1930, SKM-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HMEC

(see details)

3D Structures


At greater than 35% identity similarity to METAP1D there are:
104 structures (126 chains) solved
84 are solved in complex with at least one small molecule ligand
13 are solved with an approved drug

METAP1D is solved in complex with the approved drug(s):

MET/METHIONINE (1C21_A, 1YJ3_A, 2GGC_A, 3MX6_A, 3MX6_B, 4FO8_A, 4FO8_B, 4FO8_C, 4FO8_D, 4U6J_A, 4U75_A, 5YOH_A, 5YOI_A, 5YPD_A, 5YR7_A, 5YXF_A),
TMG/THIABENDAZOLE (1YVM_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


METAP1D has been screened with compounds ( bioactivities). (see details)