Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PAQR3 (Q6TCH7) - Overview - Molecular Target Synopsis

Protein


PAQR3, Progestin and adipoQ receptor family member 3
UniProt Q6TCH7

Also Known as PAQR3_HUMAN, PAQR3

Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PAQR3 is active in the following subcellular-locations: golgi apparatus membrane.
GO terms: PAQR3 is active in the following subcellular-locations: Golgi apparatus, Golgi membrane, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PAQR3 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: M14, K_562, CCRF_CEM

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1930, SNU-1, HCC33

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, A549

(see details)