Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RASL11A (Q6T310) - Overview - Molecular Target Synopsis

Protein


RASL11A, Ras-like protein family member 11A
UniProt Q6T310

Also Known as RSLBA_HUMAN, RASL11A

Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription. Interacts with UBF/UBTF.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
242ENSG00000122035ENST00000241463ENSP00000241463Q6T310-1

Sub-cellular localization


UniProt: RASL11A is active in the following subcellular-locations: nucleolus, nucleus.
GO terms: RASL11A is active in the following subcellular-locations: membrane, nucleolus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RASL11A has gain in 4 cell-lines, loss in 4 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_92, TK_10, HCT_116

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SW 1463, Hs 675.T, JHH-7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: BJ, AG445, SK-N-SH

(see details)

3D Structures


At greater than 35% identity similarity to RASL11A there are:
5 structures (6 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis