Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HSD11B1 (Q6QLL4) - Overview - Molecular Target Synopsis

Protein


HSD11B1, Corticosteroid 11-beta-dehydrogenase isozyme 1
Enzyme Classification 1.1.1.146
UniProt Q6QLL4

Also Known as DHI1_CAVPO, HSD11B1

Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol. Homodimer.

3LZ6
GUINEA PIG 11BETA HYDROXYSTEROID DEHYDROGENASE WITH PF-877423
RCSB/PDB
Inspect Structure
See all 3D Structures for HSD11B1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
300Q6QLL4-1

Sub-cellular localization


UniProt: HSD11B1 is active in the following subcellular-locations: endoplasmic reticulum membrane.
GO terms: HSD11B1 is active in the following subcellular-locations: endoplasmic reticulum membrane, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HSD11B1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For HSD11B1 there are:
4 structures (14 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HSD11B1 has been screened with compounds ( bioactivities). (see details)