Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DEGS2 (Q6QHC5) - Overview - Molecular Target Synopsis

Protein


DEGS2, Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2
Enzyme Classification 1.14.18.5
UniProt Q6QHC5

Also Known as DEGS2_HUMAN, DEGS2, C14orf66

Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
323ENSG00000168350ENST00000305631ENSP00000307126Q6QHC5-1
54ENSG00000168350ENST00000553834ENSP00000450637

Sub-cellular localization


UniProt: DEGS2 is active in the following subcellular-locations: endoplasmic reticulum membrane.
GO terms: DEGS2 is active in the following subcellular-locations: endoplasmic reticulum membrane, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DEGS2 has gain in 5 cell-lines, loss in 3 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, MCF7, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC2911, YMB-1, T-47D

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


DEGS2 has been screened with compounds ( bioactivities). (see details)