Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC2A7 (Q6PXP3) - Overview - Molecular Target Synopsis

Protein


SLC2A7, Solute carrier family 2, facilitated glucose transporter member 7
UniProt Q6PXP3

Also Known as GTR7_HUMAN, SLC2A7, GLUT7

High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and xylose.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
512ENSG00000197241ENST00000400906ENSP00000383698Q6PXP3-1

Sub-cellular localization


UniProt: SLC2A7 is active in the following subcellular-locations: membrane.
GO terms: SLC2A7 is active in the following subcellular-locations: integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC2A7 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to SLC2A7 there are:
2 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC2A7 has been screened with compounds ( bioactivities). (see details)